Anticancer agent 64
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization.
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- No. CAS: 2387902-92-1
- Fòrmula: C31H46N2O2S
- Peso molecular:510.77
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
|
Caspase 3 |
Caspase-7 |
Bcl-2 |
Bax |
PARP |
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
38.4 μM
Compound: 5m
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Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay
|
[PMID: 31677446] |
| BJ | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay
Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| CCRF-CEM | IC50 |
2.4 μM
Compound: 5m
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Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| HCT-116 | IC50 |
36.5 μM
Compound: 5m
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Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| HCT-116 | IC50 |
48.3 μM
Compound: 5m
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Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay
Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| K562 | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| MRC5 | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| U2OS | IC50 |
48 μM
Compound: 5m
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Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay
Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
In Vitro
Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression[1].
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Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2387902-92-1
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Peso molecular 510.77
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Fòrmula C31H46N2O2S
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SMILES
OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C6=C(SC(N)=N6)C5)C)([H])CC4)C)([H])CC3)C)C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 64 Related Classifications
HY-147514 Related Classifications
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