Pomalidomide-d4
Based on 1 Customer Validation
Pomalidomide-d4 (CC-4047-d4) is the deuterated-labeled Pomalidomide (HY-10984). Pomalidomide (CC-4047) is an immunomodulatory agent. Pomalidomide downregulates TNF-alpha, IL-1, IL-11, and IL-12, upregulates IL-2, IL-5, and IL-10, and costimulates T cells. Pomalidomide inhibits the proliferation of T regulatory cells by reducing FOXP3/OX-40 expression and IL-2-mediated expansion. Pomalidomide inhibits CDK2/4/6 and p21WAF-1, causing cell cycle arrest. Pomalidomide can be used in research on myelofibrosis-associated anemia, multiple myeloma, and colorectal cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 96.38%
- No. CAS: 1416575-78-4
- Fòrmula: C13H7D4N3O4
- Peso molecular:277.27
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas TNF Receptor
MoreVer todos los productos específicos de isoformas Orexin Receptor (OX Receptor)
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Actividad biológica
Descripciòn
|
IL-1 |
TNF-alpha |
IL-12 |
IL-2 |
IL-5 |
IL-10 |
IL-11 |
FOXP3 |
CDK2 |
OX-40 |
CDK4 |
CDK6 |
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1416575-78-4
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Unlabeled CAS 19171-19-8
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Appearance Solid
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Peso molecular 277.27
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Fòrmula C13H7D4N3O4
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Color White to yellow
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SMILES
O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C(C3=C(N)C=CC=C31)=O
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Synonyms
CC-4047-d4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pomalidomide-d4 Related Classifications
HY-10984S2 Related Classifications
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Keywords
- Pomalidomide-d4
- 1416575-78-4
- CC-4047-d4
- Isotope-Labeled Compounds
- TNF Receptor
- Interleukin Related
- FOXP
- Orexin Receptor (OX Receptor)
- CDK
- Tumor Necrosis Factor Receptor
- TNFR
- IL
- Forkhead Box P Protein
- Hypocretin Receptor
- HCRT Receptor
- Cyclin dependent kinase
- FOXP3
- IL-1
- IL-10
- IL-11
- IL-12
- IL-2
- IL-5
- T cells
- T-regulatory cell
- TNF-alpha
- Inhibitor
- inhibitor
- inhibit