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Tauroursodeoxycholate dihydrate

(Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate)
111 Cited Publications
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Based on 111 publication(s) in Google Scholar

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease.

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  • Pureza: 99.96%
  • No. CAS: 117609-50-4
  • Fòrmula: C26H49NO8S
  • Peso molecular:535.73
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Tauroursodeoxycholate dihydrate Chemical Structure
    Tauroursodeoxycholate dihydrate Chemical Structure
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
  • Experimental Validation Results for Tauroursodeoxycholate dihydrate
No. CAS: 117609-50-4
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  • Tauroursodeoxycholate dihydrate Chemical Structure
    Tauroursodeoxycholate dihydrate Chemical Structure
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    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 9. [Abstract]

    Customer Validation
     RT-qPCR analysis of sXbp1, Cxcl10, and Ptprc (CD45) in cortices of mice with Tauroursodeoxycholate sodium (TUDCA, intraperitoneally at a dose of 50 mg/kg once daily) or saline administration at day 1 post-TBI.

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    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 16;16(1):7638. [Abstract]

    Customer Validation
     Representative images of mouse colon and H&E staining. Mice were treated with GUDCA or TUDCA (400 mg/kg, twice a week) after the AOM/DSS model was established (n = 8/group). H&E staining showed normal, dysplastic mucosae and carcinoma in the colon tissues.

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    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb 3:e2411719. [Abstract]

    Customer Validation
     The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]

    Customer Validation
     q-PCR analysis of ER stress markers in macrophages treated with vehicle or Tauroursodeoxycholate sodium (TUDCA) for 24 hr. n = 8 mice each, combined from 3 independent repeats.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]

    Customer Validation
     Immunoblot of the STING pathway in macrophages pretreated with Tauroursodeoxycholate sodium (TUDCA) for 24 hr followed by DMXAA for another 1 hr. The numbers below the blot indicate relative band intensity of STING, p-STING (normalized to β-tubulin), or ratio of phosphorylated to total protein (p/t), representative of 2 independent repeats.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: BMC Mol Cell Biol. 2023 Mar 3;24(1):7. [Abstract]

    Customer Validation
     Tauroursodeoxycholate (TUDCA; 2 mM) not only suppresses the expression of RPL11-induced ERS-related proteins but also markedly mitigates the expression of LC3-II and BECN1 and increases the expression of p62 in RPL11-overexpressing NSCLC cells.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]

    Customer Validation
     Inhibition of ER stress by treatment with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM, 24 h) prominently suppressed NLRP3 expression and the levels of active caspase-1 and IL-1β in MSC2D.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]

    Customer Validation
     MSC2D was treated with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM) for 24 h.

  • 1/16

    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Aug:154:278-292. [Abstract]

    Customer Validation
     TUDCA treatment inhibits the secretion of active IL-1β into cell culture media by Acetaminophen (APAP).

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    Tauroursodeoxycholate dihydrate purchased from MedChemExpress. Usage Cited in: Fundam Clin Pharmacol. 2018 Aug;32(4):363-377. [Abstract]

    Customer Validation
     Effect of TUDCA and Fluoxetine on chronic unpredictable stress (CUS)-induced increase in Iba-1 protein expression in mice hippocampus and prefrontal cortex.

  • Tauroursodeoxycholate dihydrate