WB156
WB156 is a dual MDM2 and GSPT1 degrader. WB156 can recruit CRBN (Cereblon, a substrate receptor of the E3 ubiquitin-ligase complex) to induce the ubiquitination-proteasome pathway-mediated degradation of MDM2 and GSPT1. WB156 is promising for research of cancers, such as leukemia.
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- No. CAS: 2368944-44-7
- Fòrmula: C48H48Cl2N6O5
- Peso molecular:859.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RS4-11 | IC50 |
3.2 nM
Compound: 32
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Antiproliferative activity against human RS4:11 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human RS4:11 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 31128449] |
Chemical Information
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No. CAS 2368944-44-7
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Peso molecular 859.84
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Fòrmula C48H48Cl2N6O5
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SMILES
O=C(N1CCN(CC1)CC#CC2=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=CC=C2)N5[C@H](C6=CC=C(C=C6)Cl)[C@H](C7=CC=C(C=C7)Cl)N=C5C8=C(C=C(C=C8)C(C)(C)C)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WB156 Related Classifications
HY-174266 Related Classifications
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