Egf - epidermal growth factor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13645

Summary

This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]

Egf Products (3)

mRNA Protein Name
NM_001310737.1 NP_001297666.1 pro-epidermal growth factor isoform 2
NM_001329594.1 NP_001316523.1 pro-epidermal growth factor isoform 3
NM_010113.4 NP_034243.2 pro-epidermal growth factor isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IDA
IDA: Inferred from direct assay
6315706 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17626015 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
6248866 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
6248866 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-EGFR signaling pathway IDA
IDA: Inferred from direct assay
22822073 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IDA
IDA: Inferred from direct assay
15831470 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15509736 MGI
acts upstream of cerebellar granule cell precursor proliferation IDA
IDA: Inferred from direct assay
10027293 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
6315706 MGI
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
6248866 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
7641815 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15509736 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
10331984 MGI
involved in negative regulation of cholesterol efflux IDA
IDA: Inferred from direct assay
20037141 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
14561752 MGI
involved in positive regulation of DNA binding IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
9030684 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
8702723 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
7641815 MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation IDA
IDA: Inferred from direct assay
10027293 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15509736 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
21186272 MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7678348 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20208556 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11940581 MGI
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15156153 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
6248866 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7641815 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17626015 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-epidermal growth factor

  • Pro-epidermal growth factor precursor (EGF)

Recombinant Egf Proteins

Cat. No. Product Name Accession Purity
HY-P7067 EGF Protein, Mouse P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70590 EGF Protein, Mouse (His) P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72983 EGF Protein, Mouse (HEK293) P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72984 EGF Protein, Mouse (P.pastoris) P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72985 EGF Protein, Mouse (HEK293, Fc) P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70590AF Animal-Free EGF Protein, Mouse (His) P01132 (N977-R1029) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50895 Gefitinib 99.99% Yes
HY-50895A Gefitinib hydrochloride Inhibitor 99.85% Yes
HY-50895R Gefitinib (Standard) 99.94% Unkown
HY-50895B Gefitinib dihydrochloride / Unkown
HY-B0764B Bucladesine / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99041 Panitumumab Inhibitor 99.77% Unkown
HY-P9964 Necitumumab Inhibitor 99.90% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12872 Nazartinib Inhibitor 99.53% Phase 3
HY-101756 SDZ281-977 98.00% Phase 2
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99041B Panitumumab (powder) Inhibitor / Phase 4
HY-P99155 Zalutumumab 98.34% Phase 3
HY-P99155A Zalutumumab (powder) Inhibitor / Phase 3
HY-P990609 KHK-2866 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (96)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18723 Yoda 1 99.97% Unkown
HY-13595 Chrysophanol Inhibitor 99.73% Unkown
HY-104064 1A-116 99.72% Unkown
HY-107413 SR11237 99.99% Unkown
HY-19713 LJI308 Inhibitor 99.07% Unkown
HY-145967 FT709 Inhibitor 99.81% Unkown
HY-13896 PD168393 98.01% Unkown
HY-16160 Cysmethynil 99.07% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-101957 AG 1295 Inhibitor 99.86% Unkown
HY-10325 CL-387785 99.31% Unkown
HY-W013852 PKC-IN-6 Inhibitor 99.93% Unkown
HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) 99.46% Unkown
HY-P5107 Low molecular weight protamine Inhibitor 98.07% Unkown
HY-101960A Tyrphostin A51 Inhibitor 99.0% Unkown
HY-150687 ZINC12409120 Inhibitor 99.95% Unkown
HY-N1073 Wighteone 98.71% Unkown
HY-101219 VEGFR-IN-1 Inhibitor 99.07% Unkown
HY-101429 RG13022 Inhibitor 96.74% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-124674A CCT365623 hydrochloride 98.07% Unkown
HY-76558 Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate 99.85% Unkown
HY-101042 AG-494 Inhibitor 98.69% Unkown
HY-117393 Bisindolylmaleimide III Inhibitor 98.95% Unkown
HY-E70229 Cyclooxygenase 1, sheep / Unkown
HY-100923 H-9 Dihydrochloride Inhibitor 98.98% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-P10697A VH4127 TFA Modulator / Unkown
HY-P1985 Notch 1 95.39% Unkown
HY-50895S2 Gefitinib-d3 98.39% Unkown
HY-108931 AG 1406 Inhibitor 99.03% Unkown
HY-116111 AG 370 Inhibitor 97.0% Unkown
HY-12872B Nazartinib S-enantiomer 95.10% Unkown
HY-129510 4-Methyl erlotinib Inhibitor 99.34% Unkown
HY-133779 Gefitinib impurity 5 99.46% Unkown
HY-146127 Grb2 SH2 domain inhibitor 1 Inhibitor 98.24% Unkown
HY-50895S1 Gefitinib-d6 98.2% Unkown
HY-D2170 AF488 streptavidin / Unkown
HY-P0320B EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 99.00% Unkown
HY-P1985A Notch 1 TFA / Unkown
HY-P2673 Lys-Arg-Thr-Leu-Arg-Arg / Unkown
HY-P2673A Lys-Arg-Thr-Leu-Arg-Arg acetate / Unkown
HY-P5107A Low molecular weight protamine acetate 98.64% Unkown
HY-RS04204 EGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12872A Nazartinib mesylate Inhibitor / Unkown
HY-100663 Gefitinib impurity 2 99.56% Unkown
HY-101960 (Z)-Tyrphostin A51 Inhibitor / Unkown
HY-107413G SR11237 (GMP) / Unkown
HY-112454 Bisindolylmaleimide III hydrochloride Inhibitor / Unkown
HY-118175 RG 14921 Inhibitor / Unkown
HY-120857 BPIQ-II hydrochloride Inhibitor / Unkown
HY-122564 Pyrimidyn 7 Inhibitor / Unkown
HY-124152 3,4-Dephostatin Inhibitor / Unkown
HY-131257 Gefitinib impurity 1 99.59% Unkown
HY-13595R Chrysophanol (Standard) Inhibitor / Unkown
HY-147279 Milpocitide / Unkown
HY-149352 DG1 Inhibitor / Unkown
HY-155983 E07 aptamer / Unkown
HY-171443 Lyso-Monosialoganglioside GM3 Inhibitor / Unkown
HY-174379 KRAS IN-44 / Unkown
HY-175009 MRC-G-001 / Unkown
HY-176780 Gαi2-IN-1 Inhibitor / Unkown
HY-180536 HB-EGF-IN-1 Inhibitor / Unkown
HY-182398 BAY-693 Inhibitor / Unkown
HY-186172 KS0365 Activator / Unkown
HY-D2004 ATTO 488 streptavidin / Unkown
HY-N3634 Corylifol C / Unkown
HY-NP185 Chicken Tenascin,suitable for cell culture / Unkown
HY-P0320A EGF Receptor Substrate 2 (Phospho-Tyr5) TFA / Unkown
HY-P10301 CXCL9(74-103) / Unkown
HY-P10697 VH4127 Modulator / Unkown
HY-P11071 PCSK9 Inhibitor, EGF-A / Unkown
HY-P11484 Myosin Regulatory Light Chain MRCL3 (11-24) / Unkown
HY-P11757 Cyclo[K(N3)larllt] Ligand / Unkown
HY-P11944 Peptide 22 Chemical / Unkown
HY-P3918 EGF-R (661-681) T669 Peptide / Unkown
HY-10325R CL-387785 (Standard) / Unkown
HY-107413R SR11237 (Standard) / Unkown
HY-111072 ADS103317 Inhibitor / Unkown
HY-114667 Lavendustin C6 Inhibitor / Unkown
HY-117523 (Z)-RG-13022 Inhibitor / Unkown
HY-125066 Reveromycin B / Unkown
HY-125322 Reveromycin C / Unkown
HY-130453 CInQ-03 Inhibitor / Unkown
HY-137081 AKOS024836912 Inhibitor / Unkown
HY-156487 CNBDA Inhibitor / Unkown
HY-174671 Human HBEGF mRNA / Unkown
HY-174779 Human AREG mRNA / Unkown
HY-N11262 Sudachitin / Unkown
HY-N14173 Epiderstatin Inhibitor / Unkown
HY-N14910 Actiketal Inhibitor / Unkown
HY-N5190 Enamidonin Inhibitor / Unkown
HY-RS16498 Egf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22928 Egf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W747507 Reveromycin D / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990957 Ficerafusp alfa Inhibitor 99.71% Unkown
HY-P991967 AVID100 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egf NCBI NCBI:1950