2. Gene
  3. Jak3 - Janus kinase 3 Gene

Jak3 - Janus kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as fae; wil

Gene ID: 16453 | Gene type: protein coding

About Jak3

Chromosome 8: 72,128,940-72,143,219 forward strand.GRCm39:CM001001.3

This gene has 5 transcripts (splice variants), 103 orthologues, 32 paralogues and is associated with 124 phenotypes. Biased expression in testis adult (RPKM 193.9), spleen adult (RPKM 34.5) and 7 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of FasL production; negative regulation of cytokine production; and regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute megakaryocytic leukemia; adult T-cell leukemia; and juvenile myelomonocytic leukemia. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Jak3 Products(2)

mRNA Protein Name
NM_010589.6 NP_034719.2 tyrosine-protein kinase JAK3
NM_001190830.1 NP_001177759.1 tyrosine-protein kinase JAK3

Jak3 Protein Structure

FERM_F1

FERM_F1: cl39717 (40 - 113)

FERM_F2

FERM_F2: cl39028 (125 - 244)

FERM_C_JAK3

FERM_C_JAK3: cd13334 (249 - 358)

SH2

SH2: cl15255 (358 - 454)

PKc_like

PKc_like: cl21453 (516 - 773)

PKc_like

PKc_like: cl21453 (812 - 1094)

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Protein Preferred Names Protein Names

tyrosine-protein kinase JAK3

Related Agents

Approval
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.98% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.98% Yes
HY-18300 Filgotinib Inhibitor 99.68% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.91% Yes
HY-109053 Delgocitinib Inhibitor 99.87% Unkown
HY-13577A Oclacitinib maleate Inhibitor 99.63% Unkown
HY-13577 Oclacitinib Inhibitor 99.23% Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-18300A Filgotinib maleate Inhibitor / Unkown
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-100754 Ritlecitinib Inhibitor 99.98% Phase 3
HY-10961 Momelotinib Inhibitor 99.37% Phase 3
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-12469 Decernotinib Inhibitor 99.67% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.06% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.82% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-10963 Momelotinib Mesylate Inhibitor / Phase 3
HY-50514 AT9283 Inhibitor 99.70% Phase 2
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-15270 BMS-911543 Inhibitor 98.53% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.86% Phase 2
HY-19631A Ilginatinib Inhibitor 99.53% Phase 2
HY-112708 Brepocitinib Inhibitor 98.64% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor ≥98.0% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-13775 XL019 Inhibitor ≥98.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (57)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14435 Pyridone 6 Inhibitor 98.13% Unkown
HY-10410 TG101209 Inhibitor 99.22% Unkown
HY-15343 CEP-33779 Inhibitor 99.23% Unkown
HY-10411 AZ960 Inhibitor 97.15% Unkown
HY-15508 JANEX-1 Inhibitor 99.84% Unkown
HY-100895 SAR-20347 Inhibitor 97.12% Unkown
HY-131140 BD750 Inhibitor 99.10% Unkown
HY-13895 WHI-P154 Inhibitor 99.39% Unkown
HY-145696 SJ10542 Inhibitor 99.92% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.89% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% Unkown
HY-101976 JAK3-IN-6 Inhibitor 99.90% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.90% Unkown
HY-130247 JAK2/FLT3-IN-1 Inhibitor 99.79% Unkown
HY-102046 FM-381 Inhibitor 99.58% Unkown
HY-131906 JAK2-IN-7 Inhibitor 99.15% Unkown
HY-150023 BI-1622 Inhibitor 98.97% Unkown
HY-130247A JAK2/FLT3-IN-1 TFA Inhibitor 99.77% Unkown
HY-108264 TCS 21311 Inhibitor 99.18% Unkown
HY-139423 JAK1-IN-8 Inhibitor ≥95.0% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 98.78% Unkown
HY-11067 WHI-P97 Inhibitor 99.70% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.23% Unkown
HY-100754B (2R,5S)-Ritlecitinib Inhibitor 98.83% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.58% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-119935 JAK3 covalent inhibitor-1 Inhibitor / Unkown
HY-152080 TUL01101 Inhibitor / Unkown
HY-151285 JAK-2/3-IN-3 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-161354 JAK3 covalent inhibitor-2 Inhibitor / Unkown
HY-150720 TYK2-IN-12 Inhibitor / Unkown
HY-151259 TK4b Inhibitor / Unkown
HY-151258 TK4g Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-100849 JAK 3i Inhibitor / Unkown
HY-147741 DPPY Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-10652 JAK-2/3-IN-1 Inhibitor / Unkown
HY-151256 JAK-2/3-IN-2 Inhibitor / Unkown
HY-131014 FM-479 / Unkown
HY-153440 JAK-IN-25 Inhibitor 98.44% Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.32% Unkown
HY-133747 JAK3-IN-9 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-143444 JAK-IN-20 Inhibitor / Unkown
HY-147742 Thi-DPPY Inhibitor / Unkown
HY-123099 MS-1020 Inhibitor / Unkown
HY-12589A ZM39923 Inhibitor / Unkown
HY-10058 AT9283 lactic acid Inhibitor / Unkown
HY-U00390 JAK3-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak3 NCBI NCBI:3718