Jak3 - Janus kinase 3 Gene

Also Known as fae; wil

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16453

About Jak3

Chromosome 8: 72,128,940-72,143,219 forward strand.GRCm39:CM001001.3

This gene has 5 transcripts (splice variants), 103 orthologues, 32 paralogues and is associated with 124 phenotypes. Biased expression in testis adult (RPKM 193.9), spleen adult (RPKM 34.5) and 7 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of FasL production; negative regulation of cytokine production; and regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute megakaryocytic leukemia; adult T-cell leukemia; and juvenile myelomonocytic leukemia. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Jak3 Products (2)

mRNA Protein Name
NM_010589.6 NP_034719.2 tyrosine-protein kinase JAK3
NM_001190830.1 NP_001177759.1 tyrosine-protein kinase JAK3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10872802 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8022486 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
9498750 MGI
involved in T cell homeostasis IMP
IMP: Inferred from mutant phenotype
9498750 MGI
acts upstream of or within cellular response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
19414010 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
8022486 MGI
acts upstream of or within enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
8022486 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
8022486 MGI
involved in negative regulation of FasL production IMP
IMP: Inferred from mutant phenotype
9498750 MGI
involved in negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
9498750 MGI
involved in negative regulation of T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
16020505 MGI
involved in negative regulation of dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
16020505 MGI
involved in negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16020505 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
16020505 MGI
involved in negative regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
9973401 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
involved in positive regulation of dendritic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16020505 MGI
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
16020505 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10485657 MGI
involved in regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9498750 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10485657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jak3 Protein Structure

FERM_F1

FERM_F1: cl39717 (40 - 113)

FERM_F2

FERM_F2: cl39028 (125 - 244)

FERM_C_JAK3

FERM_C_JAK3: cd13334 (249 - 358)

SH2

SH2: cl15255 (358 - 454)

PKc_like

PKc_like: cl21453 (516 - 773)

PKc_like

PKc_like: cl21453 (812 - 1094)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1100 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.92% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.94% Yes
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-10961 Momelotinib Inhibitor 98.93% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-112961 Patiromer Inhibitor 95.0% Unkown
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-100754A Ritlecitinib malonate Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 4
HY-50514 AT9283 Inhibitor 99.67% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-13775 XL019 Inhibitor 99.65% Phase 3
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.99% Phase 3
HY-130247A Flonoltinib TFA Inhibitor 98.94% Phase 3
HY-13034 Gandotinib Inhibitor 99.86% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-159536 Frevecitinib Inhibitor 99.42% Phase 2
HY-123625 R-348 choline Inhibitor / Phase 2
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (104)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112708 Brepocitinib Inhibitor 99.95% Yes
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-131140 BD750 Inhibitor 99.02% Unkown
HY-15508 JANEX-1 Inhibitor 99.63% Unkown
HY-130247 Flonoltinib Inhibitor 99.48% Unkown
HY-145696 SJ10542 Degrader 99.32% Unkown
HY-15343 CEP-33779 Inhibitor 99.23% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-10962 Momelotinib sulfate Inhibitor 98.63% Yes
HY-10411 AZ960 Inhibitor 97.08% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-10410 TG101209 Inhibitor 98.81% Unkown
HY-19631A Ilginatinib Inhibitor 99.81% Unkown
HY-102046 FM-381 Inhibitor 98.08% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-108264 TCS 21311 Inhibitor 99.49% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.88% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 99.84% Unkown
HY-18313 S6K1-IN-1 Inhibitor 99.71% Unkown
HY-11067 WHI-P97 Inhibitor 99.16% Unkown
HY-101976 JAK3-IN-6 Inhibitor 99.48% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-174280 Modzatinib Inhibitor / Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-13895 WHI-P154 Inhibitor 98.77% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Yes
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-139423 JAK1-IN-8 Inhibitor 95.0% Unkown
HY-143444 JAK-IN-20 Inhibitor 99.63% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-136336 Tofacitinib metabolite-1 Inhibitor 99.59% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-100754B (2R,5S)-Ritlecitinib Inhibitor 99.77% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-100849 JAK 3i Inhibitor 99.81% Unkown
HY-13450 ZM 449829 Inhibitor 99.73% Unkown
HY-131014 FM-479 99.2% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-119935 JAK3 covalent inhibitor-1 Inhibitor / Unkown
HY-10058 AT9283 lactic acid Inhibitor / Unkown
HY-147741 DPPY Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-18949 JI6 Inhibitor / Unkown
HY-115438 AUH-6-96 Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-120457 WYE-151650 Inhibitor / Unkown
HY-178448 EGFR-IN-178 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-182314 JAK3-IN-20 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-168339 Tyk2-IN-22 Inhibitor / Unkown
HY-123099 MS-1020 Inhibitor / Unkown
HY-168718 FAK-IN-22 Inhibitor / Unkown
HY-161967 JAK2/FLT3-IN-3 Inhibitor / Unkown
HY-164111 JNK-IN-17 Inhibitor / Unkown
HY-151285 JAK-2/3-IN-3 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-161354 JAK3 covalent inhibitor-2 Inhibitor / Unkown
HY-173601 JAK3-IN-17 Inhibitor / Unkown
HY-187211 TYK2 activator-2 Modulator / Unkown
HY-147742 Thi-DPPY Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.10% Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-151256 JAK-2/3-IN-2 Inhibitor / Unkown
HY-181663 PJ27 Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-138222 JANEX-1 hydrochloride Inhibitor / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-178763 DEL1187-126-28-16 Inhibitor / Unkown
HY-124657 PRN-371 Inhibitor / Unkown
HY-10652 JAK-2/3-IN-1 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-178755 DEL1187-126-5-80 Inhibitor / Unkown
HY-182361 NUAK1-IN-3 / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-133747 JAK3-IN-9 Inhibitor / Unkown
HY-176793 JAK1-IN-18 Inhibitor / Unkown
HY-151258 TK4g Inhibitor / Unkown
HY-151259 TK4b Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-12589A ZM39923 Inhibitor / Unkown
HY-161912 5TTU Inhibitor / Unkown
HY-122101 NSC114792 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-10963 Momelotinib mesylate Inhibitor / Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-180512 JAK3-IN-19 Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-U00390 JAK3-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak3 NCBI NCBI:3718