JAK3 - Janus kinase 3 Gene

Also Known as JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3718

About JAK3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,824,782-17,847,982 (from NCBI)

This gene has 11 transcripts (splice variants), 103 orthologues, 32 paralogues and is associated with 129 phenotypes. Biased expression in appendix (RPKM 19.5), lymph node (RPKM 18.2) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

JAK3 Products (4)

mRNA	Protein	Name
XM_011527991.3	XP_011526293.2	tyrosine-protein kinase JAK3 isoform X2
NM_000215.4	NP_000206.2	tyrosine-protein kinase JAK3
XR_007066796.1
XM_047438786.1	XP_047294742.1	tyrosine-protein kinase JAK3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9045636	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	11909529	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7973658	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	18250158	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-15-mediated signaling pathway	IDA IDA: Inferred from direct assay	7568001	GOA
involved in interleukin-2-mediated signaling pathway	IDA IDA: Inferred from direct assay	7973659	GOA
involved in interleukin-4-mediated signaling pathway	IDA IDA: Inferred from direct assay	7538655	GOA
involved in interleukin-7-mediated signaling pathway	IDA IDA: Inferred from direct assay	9182906	GOA
involved in interleukin-9-mediated signaling pathway	IDA IDA: Inferred from direct assay	18829468	GOA
involved in negative regulation of T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	20696842	GOA
involved in response to interleukin-4	IDA IDA: Inferred from direct assay	7538655	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	7568001	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAK3 Protein Structure

Pkinase_Tyr

0
200
400
600
800
1000
1124 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase JAK3	Janus kinase 3 (a protein tyrosine kinase, leukocyte) leukocyte Janus kinase

JAK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JAK3	P52333	NAP1L1	Homo sapiens	P55209	Pull Down	32707033
Intra	JAK3	P52333	NAP1L1	Homo sapiens	P55209	Anti Tag CoIP	25852190
Intra	JAK3	P52333	MAGED2	Homo sapiens	Q9UNF1	Pull Down	32707033
Intra	JAK3	P52333	MAGED2	Homo sapiens	Q9UNF1	Anti Tag CoIP	25852190

Cross: Cross-species interaction Intra: Intraspecies interaction

JAK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82721	JAK3 Antibody (YA2466)	WB, ICC/IF	Human
HY-P84381	JAK3 Antibody (YA4078)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P84381A	JAK3 Antibody (YA4078)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P85234	JAK3 Antibody (YA4926)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human
HY-P85716	JAK3 Antibody (YA5408)	IHC-P	Human, Mouse, Rat
HY-P86474	JAK3 Antibody (YA6166)	WB, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Nk-Cell Enteropathy
Reticular Dysgenesis	Severe Combined Immunodeficiency With Leukopenia De Vaal Disease Congenital Aleukia Aleukocytosis Hematopoietic Hypoplasia, Generalized Reticular Dysgenesia Devaal Disease Rd Ak2 Deficiency Congenital Aleukocytosis Generalized Hematopoietic Hypoplasia Scid With Leukopenia RDYS
Prolymphocytic Leukemia	Pll Prolymphocytic Leukaemia Leukemia Prolymphocytic Leukemia, Prolymphocytic
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Intellectual Developmental Disorder, Autosomal Dominant 4	MRD4 Autosomal Dominant Non-Syndromic Intellectual Disability 4 Mental Retardation, Autosomal Dominant 4 Autosomal Dominant Intellectual Developmental Disorder 4
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Struma Ovarii
Janus Kinase-3 Deficiency
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Inflammatory Bowel Disease 28	Early Onset Autosomal Recessive Inflammatory Bowel Disease 28 Ibd28 Inflammatory Bowel Disease 28, Autosomal Recessive
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive Severe Combined Immunodeficiency, B Cell-Negative T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency Scid Due To Complete Rag1/2 Deficiency T B NK SCID Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, T Cell-Negative, B Cell-Negative, Nk Cell-Positive Scid, Autosomal Recessive, T-Negative/B-Positive Type Autosomal Recessive T Cell-Negative, B-Cell Negative, Nk Cell-Positive Scid Scid Due To Complete Rag1-2 Deficiency Severe Combined Immunodeficiency Due To Complete Rag1-2 Deficiency Scid, Ar, T-Cell Negative, B-Cell Negative, Nk Cell-Positive Severe Immunodeficiency, Autosomal Recessive, T-Cell Negative, B-Cell Negative, Nk Cell-Positive Jak3-Deficient Severe Combined Immunodeficiency Autosomal Recessive T Cell-Negative, B Cell-Positive, Nk Cell-Negative Severe Combined Immunodeficiency Autosomal Recessive T-B+Nk- Scid Jak3 Scid T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid T-B+ Scid Due To Jak3 Deficiency Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive Scid T Cell-Negative B Cell-Negative Nk Cell-Positive Severe Combined Immunodeficiency Autosomal Recessive T Cell-Negative/B Cell-Negative/Nk Cell-Positive Severe Combined Immunodeficiency Autosomal Recessive T-Cell Negative/B-Cell Negative/Nk-Cell Positive Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Severe Combined Immunodeficiency Autosomal Recessive T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency Autosomal Recessive T-Cell Negative/B-Cell Positive/Nk-Cell Negative Immunodeficiency, Severe Combined, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Immunodeficiency, Severe Combined, Autosomal Recessive, T-Cell Negative, B-Cell Negative, Nk Cell-Positive
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Mhc Class Ii Deficiency, Complementation Group B Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency
Purine Nucleoside Phosphorylase Deficiency	Purine-Nucleoside Phosphorylase Deficiency Pnp Deficiency Nucleoside Phosphorylase Deficiency Immunodeficiency Due To Purine Nucleoside Phosphorylase Deficiency Deficiency Of Inosine Phosphorylase Pnpase Deficiency PNPD
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Lymphoblastic Leukemia, Acute, With Lymphomatous Features	LALL Lymphomatous All Leukemia, Acute Lymphoblastic Acute Lymphoblastic Leukemia With Lymphomatous Features
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Severe Combined Immunodeficiency, Athabascan Type Severe Combined Immunodeficiency Due To Dclre1c Deficiency Rs-Scid Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation Scid Due To Artemis Deficiency Scid Due To Dclre1c Deficiency Scid, Athabascan Type Scid, Athabaskan Type Severe Combined Immunodeficiency Due To Artemis Deficiency Severe Combined Immunodeficiency, Athabaskan Type SCIDA Severe Combined Immunodeficiency, Athabascan-Type Artemis Deficiency Severe Combined Immunodeficiency Athabaskan Type Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation RSSCID Athabascan Scid Immunodeficiency, Severe Combined, Athabascan Type Severe Combined Immunodeficiency, Athabaskan-Type
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Geotrichosis
T-Cell Prolymphocytic Leukemia	T Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, T-Cell Type T-Pll T-Cell Chronic Lymphocytic Leukemia Lymphocytic Leukemia T-Cell Chronic Doid:0081042 Leukemia, T-Cell, Chronic Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-40354	Tofacitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-50858	Ruxolitinib phosphate	Inhibitor	99.97%	Yes
HY-40354A	Tofacitinib citrate	Inhibitor	99.94%	Yes
HY-100754	Ritlecitinib	Inhibitor	99.80%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-18300	Filgotinib	Inhibitor	99.77%	Yes
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-109053	Delgocitinib	Inhibitor	99.61%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.03%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.87%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-100754C	Ritlecitinib tosylate	Inhibitor	99.65%	Yes
HY-112961	Patiromer	Inhibitor	95.0%	Unkown
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-100754A	Ritlecitinib malonate	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10961	Momelotinib	Inhibitor	98.93%	Phase 3
HY-112708	Brepocitinib	Inhibitor	99.97%	Phase 3
HY-50514	AT9283	Inhibitor	99.67%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-10962	Momelotinib sulfate	Inhibitor	98.63%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.62%	Phase 3
HY-13775	XL019	Inhibitor	99.65%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Phase 3
HY-10963	Momelotinib mesylate	Inhibitor	/	Phase 3
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-130247	Flonoltinib	Inhibitor	99.48%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.23%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.81%	Phase 2
HY-156961	Cadefrecitinib	Inhibitor	99.81%	Phase 2
HY-112708A	Brepocitinib P-Tosylate	Inhibitor	99.99%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.33%	Phase 2
HY-130247A	Flonoltinib TFA	Inhibitor	98.94%	Phase 2
HY-10058	AT9283 lactic acid	Inhibitor	/	Phase 2
HY-101024	PF-06263276	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (97)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14435	Pyridone 6	Inhibitor	98.20%	Unkown
HY-131140	BD750	Inhibitor	99.02%	Unkown
HY-15508	JANEX-1	Inhibitor	99.63%	Unkown
HY-145696	SJ10542	Inhibitor	99.32%	Unkown
HY-15343	CEP-33779	Inhibitor	99.23%	Unkown
HY-145551	Atinvicitinib	Inhibitor	98.62%	Unkown
HY-10411	AZ960	Inhibitor	97.08%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.30%	Unkown
HY-10410	TG101209	Inhibitor	98.81%	Unkown
HY-102046	FM-381	Inhibitor	98.08%	Unkown
HY-100895	SAR-20347	Inhibitor	97.27%	Unkown
HY-108264	TCS 21311	Inhibitor	99.49%	Unkown
HY-151262	JAK-IN-23	Inhibitor	98.88%	Unkown
HY-12589	ZM39923 hydrochloride	Inhibitor	99.84%	Unkown
HY-18313	S6K1-IN-1	Inhibitor	99.71%	Unkown
HY-11067	WHI-P97	Inhibitor	99.16%	Unkown
HY-153701S	Envudeucitinibum	Inhibitor	99.56%	Unkown
HY-101976	JAK3-IN-6	Inhibitor	99.48%	Unkown
HY-174280	Modzatinib	Inhibitor	/	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-13895	WHI-P154	Inhibitor	98.77%	Unkown
HY-19544	JAK3-IN-1	Inhibitor	99.31%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.81%	Unkown
HY-150023	BI-1622	Inhibitor	98.02%	Unkown
HY-153440	Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate	Inhibitor	98.01%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-139423	JAK1-IN-8	Inhibitor	95.0%	Unkown
HY-143444	JAK-IN-20	Inhibitor	99.63%	Unkown
HY-136336	Tofacitinib metabolite-1	Inhibitor	99.59%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-100754B	(2R,5S)-Ritlecitinib	Inhibitor	99.77%	Unkown
HY-152080	Blovacitinib	Inhibitor	99.71%	Unkown
HY-100849	JAK 3i	Inhibitor	99.81%	Unkown
HY-13450	ZM 449829	Inhibitor	99.73%	Unkown
HY-159536	Frevecitinib	Inhibitor	99.42%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-131014	FM-479		99.2%	Unkown
HY-161618	MJ04	Inhibitor	98.08%	Unkown
HY-119935	JAK3 covalent inhibitor-1	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-174430	WWQ-131	Inhibitor	/	Unkown
HY-178282	JAK1-IN-19	Inhibitor	/	Unkown
HY-N14094	Tubulosine	Inhibitor	/	Unkown
HY-151256	JAK-2/3-IN-2	Inhibitor	/	Unkown
HY-120457	WYE-151650	Inhibitor	/	Unkown
HY-178448	EGFR-IN-178	Inhibitor	/	Unkown
HY-181663	PJ27	Inhibitor	/	Unkown
HY-170723	JAK-IN-39	Inhibitor	/	Unkown
HY-182314	JAK3-IN-20	Inhibitor	/	Unkown
HY-147975	JAK3-IN-12	Inhibitor	/	Unkown
HY-168718	FAK-IN-22	Inhibitor	/	Unkown
HY-124657	PRN-371	Inhibitor	/	Unkown
HY-151285	JAK-2/3-IN-3	Inhibitor	/	Unkown
HY-108342	PF-00956980	Inhibitor	/	Unkown
HY-178755	DEL1187-126-5-80	Inhibitor	/	Unkown
HY-133747	JAK3-IN-9	Inhibitor	/	Unkown
HY-147742	Thi-DPPY	Inhibitor	/	Unkown
HY-176793	JAK1-IN-18	Inhibitor	/	Unkown
HY-151258	TK4g	Inhibitor	/	Unkown
HY-147741	DPPY	Inhibitor	/	Unkown
HY-174999	JAK3-IN-18	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-115438	AUH-6-96	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-138222	JANEX-1 hydrochloride	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-178763	DEL1187-126-28-16	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-175684	JAK2-IN-14	Inhibitor	/	Unkown
HY-168339	Tyk2-IN-22	Inhibitor	/	Unkown
HY-10652	JAK-2/3-IN-1	Inhibitor	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-146727	JAK3-IN-11	Inhibitor	/	Unkown
HY-123099	MS-1020	Inhibitor	/	Unkown
HY-182361	NUAK1-IN-3		/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-161967	JAK2/FLT3-IN-3	Inhibitor	/	Unkown
HY-164111	JNK-IN-17	Inhibitor	/	Unkown
HY-161354	JAK3 covalent inhibitor-2	Inhibitor	/	Unkown
HY-151259	TK4b	Inhibitor	/	Unkown
HY-173601	JAK3-IN-17	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inducer	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown
HY-161912	5TTU	Inhibitor	/	Unkown
HY-130247B	Flonoltinib monomaleate	Inhibitor	/	Unkown
HY-180512	JAK3-IN-19	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inhibitor	/	Unkown
HY-12589A	ZM39923	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-122101	NSC114792	Inhibitor	/	Unkown
HY-U00390	JAK3-IN-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	JAK3	VGNC	VGNC:42177
Rattus norvegicus	JAK3	RGD	RGD:2940
Macaca mulatta	JAK3	VGNC	VGNC:73812
Felis catus	JAK3	VGNC	VGNC:67878
Bos taurus	JAK3	VGNC	VGNC:30366
Mus musculus	JAK3	MGD	MGI:99928
Others	JAK3	NCBI