Pnp - purine-nucleoside phosphorylase Gene

Also Known as Np; Np-1; Np-2; Pnp1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18950

Summary

Enables guanosine Phosphorylase activity and purine-nucleoside Phosphorylase activity. Involved in allantoin metabolic process and nucleobase-containing small molecule metabolic process. Acts upstream of or within several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lymphocyte activation; and urate biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study purine nucleoside Phosphorylase deficiency. Human ortholog(s) of this gene implicated in purine nucleoside Phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside Phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]

Pnp Products (1)

mRNA Protein Name
NM_013632.4 NP_038660.1 purine nucleoside phosphorylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanosine phosphorylase activity IDA
IDA: Inferred from direct assay
718989 MGI
enables purine-nucleoside phosphorylase activity IDA
IDA: Inferred from direct assay
109081 MGI
enables purine-nucleoside phosphorylase activity IMP
IMP: Inferred from mutant phenotype
1664183 MGI
Biological Process GO Annotation Evidence References Source
involved in AMP catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in AMP catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in AMP salvage IDA
IDA: Inferred from direct assay
8064675 MGI
acts upstream of B cell differentiation IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of DNA repair IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in GMP catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in GMP catabolic process to guanine IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in GMP salvage IDA
IDA: Inferred from direct assay
718989 MGI
acts upstream of or within GTP biosynthetic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in IMP catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in IMP salvage IDA
IDA: Inferred from direct assay
819300 MGI
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
9122228 MGI
involved in adenosine catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in adenosine catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in allantoin metabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in allantoin metabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
9122228 MGI
involved in amide catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
involved in amide catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within apoptotic mitochondrial changes IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in dAMP catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
involved in dGMP catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within dGTP metabolic process IMP
IMP: Inferred from mutant phenotype
9122228 MGI
involved in deoxyadenosine catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within deoxyguanosine catabolic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in deoxyguanosine catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within deoxyinosine catabolic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in deoxyinosine catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within guanosine catabolic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in inosine catabolic process IDA
IDA: Inferred from direct assay
8064675 MGI
acts upstream of or within inosine catabolic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
involved in inosine catabolic process IMP
IMP: Inferred from mutant phenotype
11783524 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within positive regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within positive regulation of DNA repair IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
9122228 MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
9122228 MGI
acts upstream of or within purine nucleoside metabolic process IDA
IDA: Inferred from direct assay
109081 MGI
acts upstream of or within purine nucleoside metabolic process IMP
IMP: Inferred from mutant phenotype
1664183 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
10859343 MGI
acts upstream of or within urate biosynthetic process IMP
IMP: Inferred from mutant phenotype
16964310 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
109081 MGI
located in cytosol IDA
IDA: Inferred from direct assay
109081 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

purine nucleoside phosphorylase

  • inosine phosphorylase

  • inosine-guanosine phosphorylase

  • purine-nucleoside phosphorylase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16210 Forodesine 99.62% Yes
HY-16209 Forodesine hydrochloride 99.86% Yes
HY-W011727A Pyridoxal 5'-​phosphate monohydrate 98.0% Unkown
HY-W011727 Pyridoxal 5'-phosphate hydrate 99.76% Unkown
HY-W011727AR Pyridoxal 5'-phosphate monohydrate (Standard) / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-19480 Ulodesine Inhibitor 99.32% Phase 2
HY-106934 Peldesine Inhibitor / Phase 1
HY-118047 CI 972 anhydrous Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (109)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-20336 Mc-Val-Cit-PABC-PNP 98.75% Unkown
HY-41189 Fmoc-Val-Cit-PAB-PNP 99.60% Unkown
HY-128933 AMP-PNP tetralithium Inhibitor 99.92% Unkown
HY-130777A AMP-PNP lithium hydrate 99.98% Unkown
HY-136329 β-D-glucuronide-pNP-carbonate 99.60% Unkown
HY-136136 Fmoc-Val-Ala-PAB-PNP 99.28% Unkown
HY-141142 Boc-Val-Cit-PAB-PNP 99.55% Unkown
HY-W008638 2'-Deoxyinosine 99.91% Unkown
HY-135975 MC-Val-Ala-PAB-PNP 99.31% Unkown
HY-130937 DBCO-Val-Cit-PABC-PNP 97.74% Unkown
HY-140145 Mal-PEG4-Val-Cit-PAB-PNP 98.48% Unkown
HY-137827 4-Nitrophenyl β-D-Cellobioside Substrate 99.94% Unkown
HY-140150 Azido-PEG3-Val-Cit-PAB-PNP 99.21% Unkown
HY-147164 MC-Gly-Gly-Phe-Gly-PAB-PNP 99.22% Unkown
HY-112835 Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside Substrate 98.03% Unkown
HY-P2724 Purine nucleoside phosphorylase, Microorganism / Unkown
HY-W011727S Pyridoxal Phosphate-d3 98.01% Unkown
HY-148425 Mal-amide-PEG8-Val-Ala-PAB-PNP 95.73% Unkown
HY-W039442 2′-Deoxy-2′-fluoroadenosine 99.71% Unkown
HY-139362 Enpp-1-IN-2 Inhibitor 99.51% Unkown
HY-W015996 4-Nitrophenyl-N-acetyl-α-D-galactosaminide 99.92% Unkown
HY-130932 Boc-Val-Ala-PAB-PNP 98.62% Unkown
HY-136154 Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP 96.67% Unkown
HY-148461 Mal-VC-PAB-PNP 99.21% Unkown
HY-106934A Peldesine dihydrochloride Inhibitor 99.28% Yes
HY-134420 p-Nitrophenyl α-L-fucoside Substrate 98.80% Unkown
HY-121106 9-Deazaguanine 99.01% Unkown
HY-W190913 DBCO-PEG4-Val-Cit-PAB-PNP 98.28% Unkown
HY-131156 Mal-PEG2-Val-Cit-PABA-PNP 95.68% Unkown
HY-114430 Fmoc-Phe-Lys(Boc)-PAB-PNP 98.67% Unkown
HY-136100A TCO-PEG1-Val-Cit-PABC-PNP TFA 99.69% Unkown
HY-W039911 4-Nitrophenyl α-D-galactopyranoside 98.70% Unkown
HY-160916 N3-PEG8-Oxydiacetamide-Phe-Lys(MMT)-PAB-PNP / Unkown
HY-134354A pNP-ADPr disodium 98.08% Unkown
HY-140147 Mal-amido-PEG2-Val-Cit-PAB-PNP 98.40% Unkown
HY-147021 MC-Val-D-Cit-PAB-PNP 98.08% Unkown
HY-W591374 DBCO-PEG4-Val-Ala-PAB-PNP 95.03% Unkown
HY-151726 Azido-PEG(4)-Val-Cit-PAB-PNP 98.05% Unkown
HY-W008638R 2'-Deoxyinosine (Standard) 99.77% Unkown
HY-129350 Fmoc-Phe-Lys(Trt)-PAB-PNP 98.0% Unkown
HY-137878 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid / Unkown
HY-140144 Mal-PEG1-Val-Cit-PAB-PNP 98.41% Unkown
HY-173161 Mc-d-Val-d-Cit-PAB-PNP 98.80% Unkown
HY-172291 Mal-amide-PEG8-Val-Cit-PAB-PNP 98.05% Unkown
HY-W591339 Mal-PEG8-Val-Cit-PAB-PNP 96.28% Unkown
HY-W800619 NH2-PEG4-Val-Cit-PAB-OH 99.35% Unkown
HY-129352 Cbz-Phe-(Alloc)Lys-PAB-PNP / Unkown
HY-106421 BCX-5 / Unkown
HY-129351 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP / Unkown
HY-129353 Boc-Phe-(Alloc)Lys-PAB-PNP / Unkown
HY-129361 Fmoc-Ala-Ala-Asn-PABC-PNP / Unkown
HY-134354 pNP-ADPr / Unkown
HY-136100 TCO-PEG1-Val-Cit-PABC-PNP / Unkown
HY-136105 Azido-PEG1-Val-Cit-PABC-PNP / Unkown
HY-136108 Fmoc-Gly3-Val-Cit-PAB-PNP / Unkown
HY-139247 pNPS-DHA / Unkown
HY-139856 Mal-Ala-Ala-PAB-PNP / Unkown
HY-141145 OPSS-Val-Cit-PAB-PNP / Unkown
HY-144628 Fmoc-Asn-Pro-Val-PABC-PNP 99.34% Unkown
HY-147021A MC-D-Val-Cit-PAB-PNP / Unkown
HY-148031 MC-Ala-Ala-Asn-PAB-PNP / Unkown
HY-148399 Mal-VC-PAB-PNP-CDN-A / Unkown
HY-153216 MC-Phe-Lys(MMT)-PAB-PNP / Unkown
HY-153486 N3-VC-PAB-PNP 97.35% Unkown
HY-158199 BCN-HS-PEG2-bis(PNP) / Unkown
HY-160703 DMBA-SIL-PNP / Unkown
HY-164340 Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP / Unkown
HY-176930 N-Fmoc-EvcPAB-PNP / Unkown
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / Unkown
HY-P11295 Fmoc-GGFG-PAB-PNP 98.29% Unkown
HY-P2724A Purine nucleoside phosphorylase, Bacillus sp. / Unkown
HY-RS10789 PNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11042 PPY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W145534 GlcNAcβ(1-3)GalNAc-α-pNP / Unkown
HY-W145540 Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP / Unkown
HY-W145553 GalNAcβ(1-3)GlcNAc-β-pNP / Unkown
HY-W145556 Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP / Unkown
HY-W145607 Galβ(1-3)GalNAc-β-pNP / Unkown
HY-W145622 Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP / Unkown
HY-W145631 GalNAcβ(1-4)GlcNAc-β-pNP / Unkown
HY-W357155 Gal1-β-3GlcNAc-β-PNP / Unkown
HY-W698379 Gal1-b-4GlcNAc-α-PNP / Unkown
HY-W698411 GlcNAc1-β-6GalNAc-α-PNP / Unkown
HY-W699180 Fuc1-α-2Gal1-β-3GlcNAc-β-PNP / Unkown
HY-W750387 Immucillin-G / Unkown
HY-W800847 Mal-Amide-PEG4-Val-Cit-PAB-PNP / Unkown
HY-137828 4-Nitrophenyl N,N′-diacetyl-β-D-chitobioside / Unkown
HY-141153 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP / Unkown
HY-151699 6-Azidohexanoyl-Val-Cit-PAB-PNP / Unkown
HY-151740 4-Pentynoyl-Val-Ala-PAB-PNP / Unkown
HY-160790 β-Glu-PNP / Unkown
HY-19480B Ulodesine succinate Inhibitor / Unkown
HY-20560 (Ac)Phe-Lys(Alloc)-PABC-PNP / Unkown
HY-RS16725 Pnp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23161 Pnp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W395122 Mal-PEG1-PNP-carbonate / Unkown
HY-W591286 Alkyne-Val-Cit-PAB-PNP / Unkown
HY-W591336 Alloc-Val-Ala-PAB-PNP / Unkown
HY-W591439 Fmoc-Lys(Boc)-PAB-PNP / Unkown
HY-W591440 Fmoc-Cit-PAB-PNP / Unkown
HY-W591441 Fmoc-Ala-PAB-PNP / Unkown
HY-W800617 NH2-PEG1-Val-Cit-PAB-OH / Unkown
HY-W800618 NH2-PEG3-Val-Cit-PAB-OH / Unkown
HY-W800620 NH2-PEG6-Val-Cit-PAB-OH / Unkown
HY-W800621 Fmoc-PEG2-Val-Cit-PAB-OH / Unkown
HY-W800622 Fmoc-PEG4-Val-Cit-PAB-OH / Unkown
HY-W800623 Fmoc-PEG6-Val-Cit-PAB-OH / Unkown
HY-W800624 Boc-PEG2-Val-Cit-PAB-OH / Unkown
HY-W800625 Boc-PEG4-Val-Cit-PAB-OH / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnp NCBI NCBI:4860