F2 - coagulation factor II Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29251

Summary

Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to mechanical stimulus; response to thyrotropin-releasing hormone; and response to thyroxine. Located in collagen-containing extracellular matrix and extracellular space. Used to study several diseases, including atherosclerosis; end stage renal disease; hyperhomocysteinemia; obesity; and thrombophilia (multiple). Biomarker of Bacterial pneumonia; brain edema; calcium oxalate nephrolithiasis; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, Thrombin). [provided by Alliance of Genome Resources, Apr 2022]

F2 Products (1)

mRNA Protein Name
NM_022924.2 NP_075213.2 prothrombin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
22915765 RGD
involved in positive regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
20664909 RGD
involved in response to Thyroglobulin triiodothyronine IEP
IEP: Inferred from expression pattern
18336749 RGD
involved in response to inactivity IEP
IEP: Inferred from expression pattern
16078333 RGD
involved in response to thyrotropin-releasing hormone IEP
IEP: Inferred from expression pattern
18336749 RGD
involved in response to thyroxine IEP
IEP: Inferred from expression pattern
18336749 RGD
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
21191574 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16078333 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prothrombin

  • coagulation factor 2

  • thrombin

Recombinant F2 Proteins

Cat. No. Product Name Accession Purity
HY-P74241 Coagulation Factor II/F2 Protein, Rat (HEK293, His) P18292/NP_075213.2 (Q25-R617) ≥ 90%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12956 Dinoprost 99.84% Unkown
HY-B0577 Latanoprost Agonist 99.85% Unkown
HY-113756A Latanoprost acid Agonist 98.77% Unkown
HY-19518 Latanoprostene bunod Control 99.75% Unkown
HY-12956A Dinoprost tromethamine salt 98.0% Unkown
HY-128428 Carboprost 99.84% Unkown
HY-A0195 Carboprost tromethamine 99.85% Unkown
HY-106916 Unoprostone Activator 99.0% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown
HY-B0577R Latanoprost (Standard) Agonist / Unkown
HY-19518R Latanoprostene bunod (Standard) Control / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-141637 2-Deoxy-2-fluoro-D-glucose 99.89% Phase 4
HY-129397 2,3-Dinor-11beta-prostaglandin F2alpha / Phase 4
HY-106037 PGF2α-isopropyl ester / Phase 3
HY-17644 Redaporfin 99.44% Phase 2
HY-112284 Ebopiprant Antagonist 98.65% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99712 Lonigutamab 95.00% Phase 2
HY-P991422 Stromab Inhibitor 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (238)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103447 Zearalenone Activator 98.95% Unkown
HY-18777 KC7F2 Inhibitor 99.36% Unkown
HY-112904 XRK3F2 Inhibitor 99.08% Unkown
HY-156190A NR2F2-IN-1 free base Inhibitor 99.31% Unkown
HY-15480 NSC 42834 Inhibitor 96.85% Unkown
HY-118090 L-γ-Glutamyl-L-glutamic acid 99.82% Unkown
HY-125848 Ginsenoside F2 99.92% Unkown
HY-153916 TCRS-417 99.13% Unkown
HY-Y0110 2-Naphthol 99.91% Unkown
HY-113209 8-Isoprostaglandin F2α 99.9% Unkown
HY-150270A NP-1815-PX sodium 99.51% Unkown
HY-156876 20-HETE inhibitor-2 Inhibitor 99.17% Unkown
HY-149894 MC-1-F2 Inhibitor 99.69% Unkown
HY-12956S Dinoprost-d4 99.9% Unkown
HY-107381 (+)-Cloprostenol Agonist 98.06% Unkown
HY-147058 SW2_152F Inhibitor 99.51% Unkown
HY-103462 TC-F2 Inhibitor 99.35% Unkown
HY-180561 WWQ-03-012 98.04% Unkown
HY-E70133 Endo-β-N-acetylglucosaminidase F2 / Unkown
HY-103447R Zearalenone (Standard) Activator 98.85% Unkown
HY-103447S1 Zearalenone-13C18 98.7% Unkown
HY-154992 2,4-Difluorophenylethynylcobalamin 98.97% Unkown
HY-W075400 4,9-Dibromonaphtho[2,3-c][1,2,5]thiadiazole 96.60% Unkown
HY-113209S 8-Isoprostaglandin F2α-d4 98.41% Unkown
HY-113246 15-keto-Prostaglandin F2a 99.2% Unkown
HY-118816 11β-Prostaglandin F2α 95.0% Unkown
HY-121314 Cloprostenol 99.86% Unkown
HY-151810 TP0472993 Inhibitor 98.22% Unkown
HY-162142 BB2-50F 98.60% Unkown
HY-100571 Cloprostenol isopropyl ester Agonist 98.0% Unkown
HY-118388 AS604872 Antagonist / Unkown
HY-130660 Prostaglandin F2α ethanolamide Agonist 98.2% Unkown
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% Unkown
HY-113208 13,14-Dihydro-15-keto Prostaglandin F2α 99.0% Unkown
HY-129953 9α,11β-Prostaglandin F2α 99.9% Unkown
HY-RS04631 F2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Y0110S1 2-Naphthol-d7 99.37% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-111478 Tiaprost 98.0% Unkown
HY-114810 Prostaglandin F2α serinol amide Agonist 99.41% Unkown
HY-131632 1a,1b-Dihomo prostaglandin F2α 99.9% Unkown
HY-132277S 15-Keto Bimatoprost-d5 96.65% Unkown
HY-137119 (±)5-iPF2α-VI Control 99.0% Unkown
HY-144882 (R)-HH2853 Inhibitor / Unkown
HY-156190 NR2F2-IN-1 Inhibitor / Unkown
HY-B0577S Latanoprost-d4 Agonist 98.0% Unkown
HY-RS04634 F2RL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09542 NR2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10901 POU3F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125946 Latanoprost lactone diol 99.86% Unkown
HY-W726201 5'-DMT-5-F-2'-dU Phosphoramidite 98.0% Unkown
HY-103447R1 Zearalenone in Acetonitrile (Standard) Activator / Unkown
HY-107381A (+)-Cloprostenol sodium Agonist / Unkown
HY-112904A XRK3F2 free base Inhibitor / Unkown
HY-113208A 11β-13,14-Dihydro-15-keto Prostaglandin F2α / Unkown
HY-113208AS1 11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113209A ent-8-Iso-15(S)-prostaglandin F2α / Unkown
HY-113209R 8-Isoprostaglandin F2α (Standard) / Unkown
HY-113209S2 8-Isoprostaglandin F2α-13C5 / Unkown
HY-113459S1 13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113756B rel-Latanoprost acid Agonist / Unkown
HY-113778 15-keto-17-phenyl trinor Prostaglandin F2α / Unkown
HY-113909 Dinoprost (methoxyamine) / Unkown
HY-114387 Dipyrazino[2,3-f:2',3'-h]quinoxaline / Unkown
HY-114593 ent-8-iso Prostaglandin F2α / Unkown
HY-114687 5,7-Dihydroxy-11-ketotetranorprostanoic acid / Unkown
HY-114695S Prostaglandin F2α-1-glyceryl ester-d5 / Unkown
HY-114761 Prostaglandin F2α dimethyl amine Antagonist / Unkown
HY-114850 5-trans Prostaglandin F2β / Unkown
HY-114850A (5R)-Dinoprost tromethamine / Unkown
HY-116051 16,16-Dimethylprostaglandin F2α / Unkown
HY-116051A 16,16-Dimethylprostaglandin F2β / Unkown
HY-116161 Bimatoprost isopropyl ester / Unkown
HY-116549 Prostaglandin F2α alcohol Agonist / Unkown
HY-116591 8-Iso-15-keto prostaglandin F2β / Unkown
HY-116704 11-Deoxyprostaglandin F2α Modulator / Unkown
HY-117061 Prostaglandin F2α alcohol methyl ether Agonist / Unkown
HY-118190 AL 8810 methyl ester Agonist / Unkown
HY-118294 15-OH Tafluprost Control / Unkown
HY-118599 Prostaglandin F2α ethyl amide / Unkown
HY-118648 Prostaglandin F2α methyl ester Agonist / Unkown
HY-120197 17-Phenyl trinor prostaglandin F2α methyl amide Inhibitor / Unkown
HY-120955 (+)-5-trans Cloprostenol Control / Unkown
HY-124200 AL 8810 isopropyl ester / Unkown
HY-125150 AL-3138 Antagonist / Unkown
HY-125396 11-Deoxyprostaglandin F2β / Unkown
HY-125626 8-iso-15-keto Prostaglandin F2α Agonist / Unkown
HY-129397S 2,3-Dinor-11β-prostaglandin F2α-d9 / Unkown
HY-12956B (5R)-Dinoprost / Unkown
HY-12956S1 Dinoprost-d9 / Unkown
HY-12956S2 Dinoprost-13C5 / Unkown
HY-129953A 5-trans Prostaglandin F2α / Unkown
HY-129953B 15(R)-Prostaglandin F2α / Unkown
HY-129953C 5-trans Prostaglandin F2α tromethamine / Unkown
HY-129953F Prostaglandin F2α-biotin / Unkown
HY-129953S 9α,11β-Prostaglandin F2α-d4 / Unkown
HY-129953S1 9α,11β-Prostaglandin F2α-d9 / Unkown
HY-131617 Prostaglandin F2α 1,11-lactone Control / Unkown
HY-132277 15-Keto Bimatoprost Control / Unkown
HY-136494 Fluprostenol / Unkown
HY-137024 15-Keto-PGA1 Activator / Unkown
HY-137412 PGF2α 1,15-lactone / Unkown
HY-137504 20-ethyl Prostaglandin F2α / Unkown
HY-137544 16-Phenyl tetranor Prostaglandin F2α / Unkown
HY-137585 17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Control / Unkown
HY-138244 8-iso Prostaglandin F2β / Unkown
HY-139063 16-Phenoxy tetranor prostaglandin F2α / Unkown
HY-139119 Prostaglandin F2α dimethyl amide Antagonist / Unkown
HY-139121 15(R)-17-Phenyl trinor Prostaglandin F2α Agonist / Unkown
HY-139124 15(R)-15-Methyl Prostaglandin F2α Agonist / Unkown
HY-139499 Sudemycin D6 Modulator / Unkown
HY-141637S 2-Deoxy-2-fluoro-D-glucose-13C 99.48% Unkown
HY-141637S1 2-Deoxy-2-fluoro-D-glucose-13C6,d7 / Unkown
HY-149554 17-Phenyl trinor Prostaglandin F2α dimethyl amide / Unkown
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / Unkown
HY-149926 Cathepsin Inhibitor 3 / Unkown
HY-150270 NP-1815-PX / Unkown
HY-151190 cis-4-Br-2,5-F2-PCPA Inhibitor / Unkown
HY-151453 Topoisomerase IIα-IN-4 / Unkown
HY-154606 2'-F-2'-ara-N2-ibu-dG Phosphoramidite / Unkown
HY-154854 BBDDL2059 Inhibitor / Unkown
HY-157292 2E-3-F16 / Unkown
HY-158450 FA2G2 glycan (G2F), 2-AB labelled / Unkown
HY-158459 A2G2F2 glycan / Unkown
HY-158478 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled / Unkown
HY-158481 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled / Unkown
HY-158499 FA2 glycan (G0F), 2-AA labelled / Unkown
HY-158500 FA2 glycan (G0F), 2-AB labelled / Unkown
HY-158571 17-Phenoxy trinor prostaglandin F2α / Unkown
HY-158595 15(R),19(R)-Hydroxy prostaglandin F2α / Unkown
HY-158937 15(R)-15-Methyl prostaglandin F2α methyl ester Control / Unkown
HY-163376 17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide / Unkown
HY-163552 Prostaglandin F2a/BSA / Unkown
HY-168890 TRF2-IN-1 / Unkown
HY-172574 8-iso-17-Phenyl trinor prostaglandin F2α / Unkown
HY-175105 17-Phenoxy trinor prostaglandin F2α isopropyl ester / Unkown
HY-176011 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester Agonist / Unkown
HY-181443 15(S)-15-Methyl Prostaglandin F2α ethyl amide / Unkown
HY-183844 C5F2-HCB / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown
HY-184165 F2F-202 Inhibitor / Unkown
HY-D0160 ZnAF-2F / Unkown
HY-D0161 ZnAF-2F DA / Unkown
HY-E71195 15-Hydroxyprostaglandin dehydrogenase (NAD+) / Unkown
HY-E71196 15-Hydroxyprostaglandin dehydrogenase (NADP+) / Unkown
HY-N12119 ent-Prostaglandin F2α / Unkown
HY-N12817 Anti-inflammatory agent 80 Inhibitor / Unkown
HY-N7614 Anemarrhenasaponin A2 95.38% Unkown
HY-N7857 19(R)-Hydroxy-prostaglandin F2α / Unkown
HY-R00011 hsa-let-7f-2-3p mimic / Unkown
HY-R00011A hsa-let-7f-2-3p agomir / Unkown
HY-R02559 mmu-let-7f-2-3p mimic / Unkown
HY-R02559A mmu-let-7f-2-3p agomir / Unkown
HY-RI00011 hsa-let-7f-2-3p inhibitor / Unkown
HY-RI00011A hsa-let-7f-2-3p antagomir / Unkown
HY-RI02559 mmu-let-7f-2-3p inhibitor / Unkown
HY-RI02559A mmu-let-7f-2-3p antagomir / Unkown
HY-RS03480 CYP4F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04111 E2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04630 F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04632 F2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04633 F2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04635 F2rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04636 F2rl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10898 POU2F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10905 POU4F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10911 POU5F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10913 POU6F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13206 SLC35F2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15223 TTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W006069 H-Phe(3,5-DiF)-OH 95.96% Unkown
HY-W112148 Dipyrazino[2,3-f:2',3'-h]quinoxalinehexacarboxylic acid / Unkown
HY-W399193 PGF2α 1,9-lactone Inhibitor / Unkown
HY-W456333 4,4',4'',4''',4'''',4'''''-(Dipyrazino[2,3-f:2',3'-h]quinoxaline-2,3,6,7,10,11-hexayl)hexabenzoic acid / Unkown
HY-W543340 UIO-66-F2 / Unkown
HY-W746807 Bimatoprost cyclohexyl amide Agonist / Unkown
HY-W746888 17-Phenyl trinor prostaglandin F2α diethyl amide / Unkown
HY-Y0110S 2-Naphthol-d8 / Unkown
HY-100571A (+)-5-trans Cloprostenol isopropyl ester / Unkown
HY-103447S2 Zearalenone-13C7 Activator / Unkown
HY-112284A Ebopiprant hydrochloride Antagonist / Unkown
HY-113209S1 8-Isoprostaglandin F2α-d9 / Unkown
HY-114695 Prostaglandin F2α-1-glyceryl ester / Unkown
HY-114841 ONO 207 / Unkown
HY-116502 13,14-Dihydro-15-keto prostaglandin F2α isopropyl ester / Unkown
HY-116679 17-trifluoromethylphenyl trinor Prostaglandin F2α / Unkown
HY-116889 15-Keto latanoprost acid / Unkown
HY-118520 16-Phenoxy tetranor prostaglandin F2α methyl ester / Unkown
HY-120982 (+)-15-epi Cloprostenol / Unkown
HY-124175 16-Phenoxy prostaglandin F2α ethyl amide / Unkown
HY-124219 17-Phenoxy trinor prostaglandin F2α ethyl amide Agonist / Unkown
HY-124243 N-Cyclopropyl methyl bimatoprost Agonist / Unkown
HY-125946R Latanoprost lactone diol (Standard) / Unkown
HY-128550 Carboprost methyl / Unkown
HY-137520 16-Phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide / Unkown
HY-137547 20-Hydroxy-PGF2α / Unkown
HY-149588 17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester / Unkown
HY-149749 Methylthiomcresol-C3-COOH / Unkown
HY-158782 5-trans Bimatoprost acid / Unkown
HY-172634 8-Iso-17-phenyl trinor prostaglandin F2β / Unkown
HY-174478 Mouse Pou3f2 mRNA / Unkown
HY-174545 Human POU3F2 mRNA / Unkown
HY-175062 8-iso Prostaglandin F2α ethanolamide / Unkown
HY-176014 17-Phenyl trinor prostaglandin F2α glycinamide / Unkown
HY-176017 2,3-Dinor fluprostenol / Unkown
HY-176075 16-(3-Fluorophenoxy) tetranor prostaglandin F2α methyl / Unkown
HY-176096 1α-Monohomo-17-phenyl trinor Prostaglandin F2α / Unkown
HY-176833 Prostaglandin F2α diethyl amide / Unkown
HY-178560 3'-β-F-2'-5-Me-dU / Unkown
HY-179901 17-Phenyl trinor prostaglandin F2α isopropyl amide / Unkown
HY-181444 16-Phenoxy tetranor Prostaglandin F2α methyl amide Ligand / Unkown
HY-183944 BN80933 Inhibitor / Unkown
HY-N15028 Depsidomycin Inhibitor / Unkown
HY-N8085 Icariside F2 Inhibitor / Unkown
HY-RS16873 F2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19321 E2f2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20069 Nr2f2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20583 Pou2f2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21172 Pou3f2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22308 Rpl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23314 F2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25812 E2f2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26573 Nr2f2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27091 Pou2f2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27689 Pou3f2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W353470 2,3-Dinor-8-iso prostaglandin F 2α / Unkown
HY-W408869 8-iso-13,14-dihydro-15-keto Prostaglandin F2α / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W592835 5'-O-DMT-4'-F-2-F-A-CE phosphoramidite / Unkown
HY-W701877 Latanoprost tris(triethylsilyl) ether Control / Unkown
HY-W746889 17-Phenyl trinor prostaglandin F2α 1,15-lactone / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990284 Anti-Mouse CD205 Antibody (NLDC-145) 95% Unkown
HY-P99891 Rovelizumab Inhibitor 97.23% Unkown
HY-P990597 HuGAL-F2 Inhibitor 98.30% Unkown
HY-P990823 Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2 NCBI NCBI:2147