Anticancer agent 64
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2387902-92-1
- 分子式: C31H46N2O2S
- 分子量:510.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Caspase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Caspase 3 |
Caspase-7 |
Bcl-2 |
Bax |
PARP |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
38.4 μM
Compound: 5m
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Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| BJ | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay
Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| CCRF-CEM | IC50 |
2.4 μM
Compound: 5m
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Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| HCT-116 | IC50 |
36.5 μM
Compound: 5m
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Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| HCT-116 | IC50 |
48.3 μM
Compound: 5m
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Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay
Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| K562 | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| MRC5 | IC50 |
>50 μM
Compound: 5m
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Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay
Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
| U2OS | IC50 |
48 μM
Compound: 5m
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Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay
Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay
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[PMID: 31677446] |
体外実験
Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression[1].
.
Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2387902-92-1
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分子量 510.77
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分子式 C31H46N2O2S
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SMILES
OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C6=C(SC(N)=N6)C5)C)([H])CC4)C)([H])CC3)C)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 64 関連分類
HY-147514 関連分類
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