Bcr - BCR activator of RhoGEF and GTPase Gene

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 309696

Summary

Enables enzyme binding activity. Involved in platelet-derived growth factor receptor signaling pathway and protein autophosphorylation. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Bcr Products (2)

mRNA Protein Name
XM_039099171.1 XP_038955099.1 breakpoint cluster region protein isoform X1
XM_039099172.1 XP_038955100.1 breakpoint cluster region protein isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables enzyme binding IPI
IPI: Inferred from physical interaction
10403766 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20962234 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11560856 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11560856 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20962234 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
20962234 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breakpoint cluster region protein

  • BCR, RhoGEF and GTPase activating protein

  • breakpoint cluster region homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-10181 Dasatinib 99.85% Yes
HY-15463 Imatinib 99.95% Yes
HY-10159 Nilotinib 99.94% Yes
HY-50946 Imatinib Mesylate 99.97% Yes
HY-104010 Asciminib Inhibitor 99.61% Yes
HY-15666 Olverembatinib Inhibitor 99.47% Yes
HY-10181A Dasatinib hydrochloride 99.67% Yes
HY-129390 Orelabrutinib Inhibitor 99.97% Yes
HY-10159A Nilotinib monohydrochloride monohydrate 99.91% Yes
HY-13904 Flumatinib Inhibitor 99.94% Unkown
HY-10181B Dasatinib monohydrate 99.58% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.79% Yes
HY-15728 Radotinib 99.19% Yes
HY-15666A Olverembatinib dimesylate Inhibitor 99.80% Yes
HY-13905 Flumatinib mesylate Inhibitor 99.80% Unkown
HY-50946R Imatinib Mesylate (Standard) 99.98% Unkown
HY-10159B Nilotinib hydrochloride 99.86% Yes

Clinical Phase

Bioactive Molecules (15)
製品番号 製品名 製品効果
純度 Phase
HY-160167 Birelentinib Inhibitor / Phase 3
HY-13024 Rebastinib 99.84% Phase 2
HY-50868 Bafetinib 99.18% Phase 2
HY-137460 Vodobatinib Inhibitor 98.09% Phase 2
HY-109010 Poseltinib Inhibitor 98.11% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-147414 Vamotinib Inhibitor 99.89% Phase 2
HY-120508 Pivanex 95.0% Phase 2
HY-10212A BIIB021 mesylate / Phase 2
HY-13468A KW-2478 hydrochloride / Phase 2
HY-15493 AN-019 Inhibitor / Phase 2
HY-147308 Zelenirstat Inhibitor 99.76% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-103275 Adaphostin 99.02% Phase 1
HY-118084 LS-104 / Phase 1
阻害性抗体 (2)
製品番号 製品名 製品効果
純度 Phase
HY-P99761 Obexelimab 99.99% Phase 3
HY-P991900 LY3541860 Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (161)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-13520 Nocodazole 99.59% Unkown
HY-13264 Degrasyn 99.70% Unkown
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-160141 Catadegbrutinib 99.18% Unkown
HY-158145 DS55980254 Inhibitor 99.25% Unkown
HY-157562 DS68591889 99.18% Unkown
HY-13468 KW-2478 99.53% Unkown
HY-118144 PD166326 Inhibitor 99.99% Unkown
HY-11007 GNF-2 Inhibitor 99.82% Unkown
HY-152036A SIAIS100 TFA Degrader 99.75% Unkown
HY-125834 GMB-475 98.69% Unkown
HY-15738 GNF-5 Inhibitor 99.95% Unkown
HY-128756 SIAIS178 Inhibitor 98.64% Unkown
HY-10181S Dasatinib-d8 99.15% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib 97.19% Unkown
HY-153357 NRX-0492 98.30% Unkown
HY-10159S Nilotinib-d6 99.95% Unkown
HY-103274 PD180970 99.27% Unkown
HY-156640 Rocbrutinib Inhibitor 99.76% Unkown
HY-15814 HG-7-85-01 98.14% Unkown
HY-163962 L18I 99.89% Unkown
HY-100338 CNX-500 Inhibitor 99.86% Unkown
HY-153415 PROTAC BCR-ABL Degrader-1 Degrader 98.73% Unkown
HY-13943 CNX-774 Inhibitor 99.54% Unkown
HY-15463S1 Imatinib-d4 99.82% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% Unkown
HY-15463S Imatinib-d8 99.88% Unkown
HY-136268 AQX-435 Activator 99.15% Unkown
HY-153996 CT1113 99.61% Unkown
HY-10159C Nilotinib hydrochloride dihydrate 99.89% Unkown
HY-13520R Nocodazole (Standard) 98.40% Unkown
HY-101489A GZD856 formic 95.36% Unkown
HY-117718 AG957 Inhibitor 99.30% Unkown
HY-123450 S116836 99.78% Unkown
HY-13904S Flumatinib-d3 Inhibitor 99.9% Unkown
HY-145887 BCR-ABL1-IN-1 99.82% Unkown
HY-157327 AKE-72 Inhibitor 98.29% Unkown
HY-164393 ON044580 99.11% Unkown
HY-123159 AKI603 Inhibitor 98.03% Unkown
HY-133794 Dasatinib N-oxide 99.24% Unkown
HY-111872 SNIPER(ABL)-020 Inhibitor 99.79% Unkown
HY-10181G Dasatinib (GMP) / Unkown
HY-108486 Herbimycin A Inhibitor 99% Unkown
HY-123390 DB07107 Inhibitor / Unkown
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor 99.17% Unkown
HY-153008 BCR-ABL-IN-7 Inhibitor 99.66% Unkown
HY-15463S2 Imatinib-d3 hydrochloride 95.19% Unkown
HY-154860 PTD10 97.38% Unkown
HY-156148 BCR-ABL-IN-8 Inhibitor / Unkown
HY-180982 Asciminib-NH2 Degrader 97.0% Unkown
HY-10181S1 Dasatinib-d4 97.54% Unkown
HY-41940 Dasatinib intermediate-1 Control ≥98.0% Unkown
HY-101489 GZD856 / Unkown
HY-108704 CT-721 Inhibitor / Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-111871 SNIPER(ABL)-033 Inhibitor / Unkown
HY-128607 Mcl1-IN-9 Inhibitor / Unkown
HY-136526 BCR-ABL-IN-3 Inhibitor / Unkown
HY-182792 Embibatinib Inhibitor / Unkown
HY-111851 SNIPER(ABL)-049 Inhibitor / Unkown
HY-111854 SNIPER(ABL)-015 Inhibitor / Unkown
HY-111858 SNIPER(ABL)-050 Inhibitor / Unkown
HY-111859 SNIPER(ABL)-058 Inhibitor / Unkown
HY-111860 SNIPER(ABL)-013 Inhibitor / Unkown
HY-111861 SNIPER(ABL)-024 Inhibitor / Unkown
HY-111862 SNIPER(ABL)-044 Inhibitor / Unkown
HY-111873 SNIPER(ABL)-019 Inhibitor / Unkown
HY-13024A Rebastinib tosylate / Unkown
HY-165532 SGX393 Inhibitor / Unkown
HY-133794S Dasatinib N-oxide-d8 / Unkown
HY-100314 BCR-ABL-IN-1 Inhibitor / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-10159S1 Nilotinib-13C,d3 / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-10181GL Dasatinib (GMP Like) / Unkown
HY-10364 AP24163 Inhibitor / Unkown
HY-104010S Asciminib-d4 Inhibitor / Unkown
HY-111863 SNIPER(ABL)-047 Inhibitor / Unkown
HY-111874 SNIPER(ABL)-039 Inhibitor / Unkown
HY-112404 BCR-ABL-IN-13 Inhibitor 99.86% Unkown
HY-119177 PD173956 Inhibitor / Unkown
HY-120036 Tyrphostin AG1112 Inhibitor / Unkown
HY-12292G IM-12 (GMP) / Unkown
HY-124605 IQS-019 / Unkown
HY-124792 MRLB-223 / Unkown
HY-125090 PHA-680626 / Unkown
HY-126143 CHMFL-ABL-039 Inhibitor / Unkown
HY-131275 Imatinib Impurity E 96.05% Unkown
HY-142922 BCR-ABL-IN-4 Inhibitor / Unkown
HY-147581 BTK-IN-11 Inhibitor / Unkown
HY-147584 BTK-IN-14 Inhibitor / Unkown
HY-150566 BCR-ABL-IN-5 Inhibitor / Unkown
HY-150569 BCR-ABL-IN-6 Inhibitor / Unkown
HY-150908 Brigatinib A Ligand / Unkown
HY-152036 SIAIS100 Degrader / Unkown
HY-153085 CD19 CAR circRNA / Unkown
HY-153582 ML 2-23 Degrader / Unkown
HY-15728S Radotinib-d6 / Unkown
HY-157389 AK-HW-90 Inhibitor / Unkown
HY-160478 GNF-6 Inhibitor / Unkown
HY-161323 FLT3-ITD/D835Y-IN-1 / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162257 BTK-IN-34 Inhibitor / Unkown
HY-162489 Tyrosine kinase-IN-8 Inhibitor / Unkown
HY-162698 JMF4073 Inhibitor / Unkown
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / Unkown
HY-169230 BCR-ABL-IN-9 Inhibitor / Unkown
HY-169231 BCR-ABL-IN-10 Inhibitor / Unkown
HY-171184 EAPB0503 / Unkown
HY-172096 cSRC/BCR-ABL-IN-1 Inhibitor / Unkown
HY-176269 VS1150 / Unkown
HY-177273 Kinase modulator-1 Inhibitor / Unkown
HY-179247 BCR-ABL1-IN-2 Inhibitor / Unkown
HY-179460 Radotinib dihydrochloride / Unkown
HY-180218 DS-PPE-GW Degrader / Unkown
HY-180798 BCR-ABL degrader 1 Degrader / Unkown
HY-180925 Leu-PEG1-Dasa Degrader / Unkown
HY-180962 Phe-PEG1-Dasa Degrader / Unkown
HY-180963 Lys-PEG1-Dasa Degrader / Unkown
HY-180967 PROTAC BCR-ABL Degrader-2 / Unkown
HY-180968 GMB-805 Degrader / Unkown
HY-180969 SIAIS056 Degrader / Unkown
HY-180977 P19P Degrader / Unkown
HY-180979 P22D Degrader / Unkown
HY-180981 P19As Degrader / Unkown
HY-180983 Azo-PROTAC-4C-trans Degrader / Unkown
HY-180984 trans-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl / Unkown
HY-180985 Azo-PROTAC-4C-cis Degrader / Unkown
HY-181546 Ibt-DOX / Unkown
HY-184728 Antifungal agent-169 Inhibitor / Unkown
HY-185658 3'-BPANeuGc Inhibitor / Unkown
HY-185659 6'-BPANeuGc / Unkown
HY-185916 BCR-ABL-IN-14 Inhibitor / Unkown
HY-186016 Arg-PEG1-Dasa Degrader / Unkown
HY-186166 (S)-Embibatinib Inhibitor / Unkown
HY-18819 BCR-ABL-IN-2 Inhibitor / Unkown
HY-E70634 ABL1 E255K Recombinant Human Active Protein Kinase / Unkown
HY-E70635 ABL1 F317I Recombinant Human Active Protein Kinase / Unkown
HY-E70636 ABL1 G250E Recombinant Human Active Protein Kinase / Unkown
HY-E70637 ABL1 H396P Recombinant Human Active Protein Kinase / Unkown
HY-E70638 ABL1 M351T Recombinant Human Active Protein Kinase / Unkown
HY-E70639 ABL1 Q252H Recombinant Human Active Protein Kinase / Unkown
HY-E70640 ABL1 T315I Recombinant Human Active Protein Kinase / Unkown
HY-E70641 ABL1 Y253F Recombinant Human Active Protein Kinase / Unkown
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / Unkown
HY-E70808 BTK C481R Recombinant Human Active Protein Kinase / Unkown
HY-E70809 BTK V416L Recombinant Human Active Protein Kinase / Unkown
HY-RS01450 BCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123486 HS-438 / Unkown
HY-132549S Nilotinib-d3 / Unkown
HY-15463S3 Imatinib-13C,d3 / Unkown
HY-160174 BCR-ABL kinase-IN-3 Inhibitor / Unkown
HY-160174A BCR-ABL kinase-IN-3 (dihydrocholide) Inhibitor / Unkown
HY-164469 CHMFL-48 Inhibitor / Unkown
HY-169608 BCR-ABL-IN-11 Inhibitor / Unkown
HY-185595 N,3-BisBoc-L-Histidine / Unkown
HY-186223 Enzyme modulator-1 Modulator / Unkown
HY-RS16598 Bcr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23032 Bcr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P991086 MGD010 Inhibitor 99.06% Unkown
HY-P991804 Anti-Mouse CD79b Antibody (HM79b) Inhibitor / Unkown
HY-P991820 Anti-Mouse CD45 Antibody (I3/2.3) Inhibitor / Unkown
HY-P991996 SM201 Inhibitor / Unkown
HY-P991816 Mouse IgM, Isotype Control / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Bcr NCBI NCBI:613