PP487
PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1092787-12-6
- 分子式: C14H14BrN5O
- 分子量:348.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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p110α 0.046 μM (IC50) |
p110β 0.24 μM (IC50) |
p110δ 0.027 μM (IC50) |
p110γ 0.1 μM (IC50) |
Abl 0.021 μM (IC50) |
VEGFR2 0.055 μM (IC50) |
PP487 (0.001-50 µM) potently inhibits nanomolar-concentration tyrosine kinases (including Src) as well as members of the PI3-K family (including mTOR), while maintaining high selectivity toward the serine-threonine kinase panel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1092787-12-6
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分子量 348.20
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分子式 C14H14BrN5O
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SMILES
BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PP487 関連分類
HY-15268 関連分類
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