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Cat. No.: HY-175815

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Apoptosis inducer 44

Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer.

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화학식: C₃₀H₃₆F₃NO
분자량:483.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Apoptosis inducer 44 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Caspase 3

Bax

Bcl-2

MMP-2

MMP-9

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All MMP Isoforms :

In Vitro

Apoptosis inducer 44 (Compound 19) (72 h) shows cytotoxic activity against MDA-MB-231 cells, MCF-7 cells, 4T1 cells and Aml-12 cells, with IC₅₀ values of 4.13, 8.60, 39.95 and 31.60 μM^[1].
Apoptosis inducer 44 (10‑40 μM) induces MDA-MB-231 cells apoptosis via the mitochondrial pathway^[1].
Apoptosis inducer 44 (5-40 μM) suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2/MMP-9 expression and up-regulating E-cadherin protein levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Apoptosis inducer 44 (Compound 19) (20 mg/kg, for 18 days) significantly suppresses tumor growth in nude mice xenografted with MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 483.61
화학식 C₃₀H₃₆F₃NO
SMILES

OC1=CC=C(/C=C/C(C=C)(C)CC/C=C(C)\C)C=C1C(N2CCCCC2)C3=CC(F)=C(F)C(F)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li HM, et al. Synthesis and anti-breast cancer evaluation of new bakuchiol derivatives. Bioorg Med Chem Lett. 2025 Dec 1;128:130361. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Apoptosis inducer 44

All Bcl-2 Family Isoforms

All Caspase Isoforms

All MMP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Apoptosis inducer 44 Related Classifications

HY-175815 Related Classifications