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Cat. No.: HY-10984S2

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Pomalidomide-d₄

Name: Pomalidomide-d4
Brand: MedChemExpress
SKU: HY-10984S2
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: CC-4047-d₄)

고객리뷰

Based on 1 Customer Validation

Pomalidomide-d₄ (CC-4047-d₄) is the deuterated-labeled Pomalidomide (HY-10984). Pomalidomide (CC-4047) is an immunomodulatory agent. Pomalidomide downregulates TNF-alpha, IL-1, IL-11, and IL-12, upregulates IL-2, IL-5, and IL-10, and costimulates T cells. Pomalidomide inhibits the proliferation of T regulatory cells by reducing FOXP3/OX-40 expression and IL-2-mediated expansion. Pomalidomide inhibits CDK2/4/6 and p21^WAF-1, causing cell cycle arrest. Pomalidomide can be used in research on myelofibrosis-associated anemia, multiple myeloma, and colorectal cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 96.38%
CAS No.: 1416575-78-4
화학식: C₁₃H₇D₄N₃O₄
분자량:277.27

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Pomalidomide-d₄ Chemical Structure

CAS No.: 1416575-78-4

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]^[2]^[3]^[4]

IL-1

TNF-alpha

IL-12

IL-2

IL-5

IL-10

IL-11

FOXP3

CDK2

OX-40

CDK4

CDK6

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All FOXP Isoforms :

FOXP3

All Orexin Receptor (OX Receptor) Isoforms :

All CDK Isoforms :

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1416575-78-4
Unlabeled CAS 19171-19-8
Appearance Solid
분자량 277.27
화학식 C₁₃H₇D₄N₃O₄
Color White to yellow
SMILES

O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C(C3=C(N)C=CC=C31)=O
Synonyms

CC-4047-d₄
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tefferi A, et al. Pomalidomide is active in the treatment of anemia associated with myelofibrosis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Sep 20;27(27):4563-9.

[2]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501. [Content Brief]

[3]. Galustian C, et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer immunology, immunotherapy : CII. 2009 Jul;58(7):1033-45.

[4]. Verhelle D, et al. Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer research. 2007 Jan 15;67(2):746-55.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
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- IC₅₀ & Target
- 신청
Chemical Information
순도&문서
References

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Pomalidomide-d₄

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All FOXP Isoforms

All Orexin Receptor (OX Receptor) Isoforms

All CDK Isoforms

Biological Activity

제품 설명

IC₅₀ & Target

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

Pomalidomide-d4

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All FOXP Isoforms

All Orexin Receptor (OX Receptor) Isoforms

All CDK Isoforms

Biological Activity

제품 설명

IC50 & Target

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Pomalidomide-d4 Related Classifications

HY-10984S2 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

Pomalidomide-d₄

IC₅₀ & Target

Pomalidomide-d₄ Related Classifications