Porphyra 334
Based on 1 Customer Validation
Porphyra 334 is a carnosine-like amino acid and a natural photoprotective agent and antioxidant. Porphyra-334 exerts its photoprotective effects by scavenging ROS, inhibiting the expression and activity of MMP-1/8, and promoting the synthesis of collagen and elastin. Porphyra 334 effectively inhibits linoleic acid oxidation induced by alkyl radicals (AAPH) and singlet oxygen. Porphyra 334 has anti-obesity potential by inhibiting the expression of PPARγ2 and C/EBPα. Porphyra 334 protects cells against UV-induced DNA damage and apoptosis by inhibiting the activation of caspase-3.
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- Purity: 99.58%
- CAS No.: 70579-26-9
- 화학식: C14H22N2O8
- 분자량:346.33
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PPARγ2 |
MMP-1 |
MMP-8 |
Caspase 3 |
Porphyra-334 (6.25-200 μM; 24 h) shows no cytotoxicity against 3T3-L1 preadipocytes at the highest concentration of 200 μM[1].
Porphyra-334 (0.1-1.0 μM) inhibits lipid droplet accumulation in mature 3T3-L1 adipocytes in a dose-dependent manner[1].
Porphyra-334 (0.1-1.0 μM; 5 days) dose-dependently and significantly reduces the mRNA expression levels of PPARγ2, C/EBPα, adiponectin, and leptin in 3T3-L1 cells[1].
Porphyra-334 (0.1 mg/mL; 24-96 h) restores cell proliferation to approximately 88% of that in the unirradiated control group by reducing caspase-3 activation, DNA fragmentation, and the number of apoptotic cells, thereby alleviating UV-induced apoptosis in HaCaT cells[2].
Porphyra 334 (10-40 μM; 24 h) protects human skin fibroblasts (CCD-986sk) exposed to long-wave ultraviolet (UVA) radiation from photoaging by scavenging reactive oxygen species (ROS), inhibiting the expression of MMP-1/MMP-8 and elastase activity, and increasing the levels of procollagen, type I collagen and elastin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1 preadipocytes
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Concentration:6.25, 12.5, 25, 50, 200 μM
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Incubation Time:24 h
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Result:Showed no cytotoxic effect on 3T3-L1 cells at concentrations <200 μM, with cell viability comparable to the control group; Observed no morphological changes similar to the control.
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Cell Line:3T3-L1 cells
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Concentration:0.1 and 1.0 μM
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Incubation Time:5 days
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Result:Significantly reduced the mRNA expression of peroxisome proliferator-activated receptor γ2 (PPARγ2), CCAAT/enhancer-binding protein α (C/EBPα), adiponectin, and leptin in a dose-dependent manner.
Chemical Information
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CAS No. 70579-26-9
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Appearance Solid
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분자량 346.33
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화학식 C14H22N2O8
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SMILES
C[C@@H](O)[C@@H](C(O)=O)/N=C1C(OC)=C(C[C@](O)(C/1)CO)NCC(O)=O
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Structure Classification
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Initial Source
Palythoa tuberculosa
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[2]. Suh SS, et al. Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells. Acta Pharm. 2017;67(2):257-264. [Content Brief]
[3]. Ryu J, et al. Protective effect of porphyra-334 on UVA-induced photoaging in human skin fibroblasts. Int J Mol Med. 2014;34(3):796-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Porphyra 334 Related Classifications
HY-126956 Related Classifications
Powered by Bioz
- Porphyra 334
- 70579-26-9
- Porphyra334
- Porphyra-334
- Reactive Oxygen Species (ROS)
- MMP
- Collagen
- PPAR
- DNA/RNA Synthesis
- Apoptosis
- Caspase
- CCAAT/enhancer-binding protein alpha (C/EBPα)
- 3T3-L1 cells
- laver
- human skin fibroblasts
- HaCaT cells
- peroxisome proliferator-activated receptor gamma 2 (PPARγ2)
- CCD-986sk
- leptin
- matrix metalloproteinase-1 (MMP-1)
- adiponectin (ADIPOQ)
- Inhibitor
- inhibitor
- inhibit