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Cat. No.: HY-14584

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PQ-1

PQ-1 is a gap junction enhancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 955995-48-9
화학식: C₂₁H₂₂F₃N₃O₂
분자량:405.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PQ-1 Chemical Structure

CAS No.: 955995-48-9

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PQ-1 is a gap junction enhancer. PQ-1 activates p44/42 MAPK, increases phosphorylated p38-MAPK, reduces Bcl-2 expression, increases the cleavage of pro-caspase-3. PQ-1 affects the Raf-MEK-ERK cascade, induces Apoptosis. PQ-1 can be used in the research of breast cancer^[1].

All p38 MAPK Isoforms :

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All Raf Isoforms :

All MEK Isoforms :

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T47D	IC₅₀	119 nM Compound: 1	Cell viability of human T47D cells by trypan blue exclusion assay Cell viability of human T47D cells by trypan blue exclusion assay	[PMID: 18457950]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 955995-48-9
분자량 405.41
화학식 C₂₁H₂₂F₃N₃O₂
SMILES

NCCCNC1=C2C(C(C)=CC=N2)=C(OC3=CC=CC(C(F)(F)F)=C3)C(OC)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shishido SN, et al. Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jan 29;17(2):178. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- Clinical Trial
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
CAS No.:
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Purity:
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PQ-1

All p38 MAPK Isoforms

All Bcl-2 Family Isoforms

All Caspase Isoforms

All Raf Isoforms

All MEK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PQ-1 Related Classifications

HY-14584 Related Classifications