Murine Thrombin
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Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus.
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- CAS. Nr.: 9002-04-4
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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PAR1 |
MMP-3 |
MMP-9 |
Murine Thrombin (100 nM; 72 h) induces degeneration in cultured mouse intervertebral discs and promotes the production of MCP-1 and VEGF[1].
Murine Thrombin (100 nM) induces the polarization of mouse bone marrow-derived macrophages toward an M1-like phenotype by upregulating the expression of M1 markers and downregulating the expression of M2 markers[1].
Murine Thrombin (0.1-1 U/mL; 12-48 h) upregulates the expressions of CCL22, MRC-1 (CD206), MMP9 and CD36 in murine macrophages[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 9002-04-4
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Appearance Solid
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Color White to off-white
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SMILES
[Murine Thrombin]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Tatsuno R, et al. Thrombin induces degradation of murine intervertebral discs via angiogenesis and M1-like polarization of macrophages. Sci Rep. 2025;15(1):34817. Published 2025 Oct 6. [Content Brief]
[2]. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019;67(2):227-234. [Content Brief]
[3]. Ukan Ü, et al. Effect of Thrombin on the Metabolism and Function of Murine Macrophages. Cells. 2022;11(10):1718. Published 2022 May 23. [Content Brief]
[4]. Marino F, et al. Structural basis of Na+ activation mimicry in murine thrombin. J Biol Chem. 2007;282(22):16355-16361. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Murine Thrombin Related Classifications
Art. -Nr.: HY-114164G
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- Murine Thrombin
- 9002-04-4
- Thrombin
- Protease Activated Receptor (PAR)
- MMP
- VEGFR
- Epigenetic Reader Domain
- oxidized low-density lipoprotein (oxLDL)
- fibrinogen
- Proteinase-activated receptor 1 (PAR1)
- PAR4
- monocyte chemotactic protein-1 (MCP-1)
- pERK pathway
- secreted modular Ca2?-binding protein 1 (SMOC1)
- protein C
- matrix metalloproteinase 3 (MMP3)
- clotting cascade
- Inhibitor
- inhibitor
- inhibit