Fezakinumab
Based on 1 Customer Validation
Fezakinumab (ILV 094) is an anti-IL-22 monoclonal antibody. Fezakinumab inhibits IL-22 signal transduction, and regulates the JAK1/STAT3 pathway as well as apoptotic proteins. Fezakinumab alleviates airway remodeling, alveolar enlargement and inflammatory cell infiltration in lung tissues. Fezakinumab reduces the levels of neutrophils, lymphocytes, eosinophils and macrophages in lung tissues. Fezakinumab can be used in the research of chronic obstructive pulmonary disease and skin diseases.
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- Pureté: 99.9%
- CAS No.: 1007106-86-6
- Masse moléculaire:144.84 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Human IgG1 lambda2
Human
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IL-22 |
JAK1 |
STAT3 |
Caspase 3 |
Bcl-2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 8-10 weeks old, 18-22 g, cigarette smoke-induced COPD model)[1]
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Dosage:5 mg/kg
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Administration:i.p.; once daily; 8 weeks
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Result:Reduced T-22 cell levels in BALF.
Reduced IL-22 levels in BALF.
Reduced average alveolar intercept.
Increased alveolar count.
Lowered lung tissue inflammatory cell infiltration (neutrophils, lymphocytes, eosinophils, macrophages).
Reduced IL-22R1 expression in lung tissue.
Reduced lung tissue levels of JAK1, p-STAT3, Caspase3, and STAT3.
Increased lung tissue levels of Bcl-2.
Showed no significant difference in Bax and TYK2 levels compared to the CS group.
Improved lung architecture, with more uniform alveolar size, reduced airway epithelial proliferation, minimal interstitial thickening, and markedly reduced inflammatory cell infiltration.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 lambda2
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 1007106-86-6
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Appearance Liquid
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Masse moléculaire 144.84 kDa
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Color Colorless to light yellow
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SMILES
[Fezakinumab]
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Synonyms
ILV 094
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fezakinumab Related Classifications
HY-P99244 Related Classifications
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