Art. -Nr.: HY-134000

Emodic acid

(Synonyms: NSC624610)

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Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.

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Reinheit: 98.00%
CAS. Nr.: 478-45-5
Formel: C₁₅H₈O₇
Molecular Weight:300.22

Speicherung:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Emodic acid Chemical Structure

CAS. Nr.: 478-45-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle JNK Isoform-spezifische Produkte anzeigen :

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle MMP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]
Jurkat	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]
K562	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]

In Vitro

Emodic acid(0-100 μM, 72 h) exhibits strong antiproliferative activity with the IC₅₀ values of 9.33, 8.56, 7.95 μM in murine mammary carcinoma 4T1, MDA-231 and MCF-7 cell lines, respectively^[1].
Emodic acid (50 μM, 24 h) can significantly inhibit NF-κB transcriptional activity by 80.75%, inhibit p65 phosphorylation and the mRNA expression of MMP-9 in 4T1 cell line^[1].
Emodic acid(50 μM, 24 h) can inhibit the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of VEGF, thereby inhibiting the invasion and migration of 4T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 478-45-5
Appearance Solid
Molecular Weight 300.22
Formel C₁₅H₈O₇
Color Brown to red
SMILES

OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O
Synonyms

NSC624610
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 4 mg/mL (13.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3309 mL

16.6545 mL

33.3089 mL

5 mM

0.6662 mL

3.3309 mL

6.6618 mL

10 mM

0.3331 mL

1.6654 mL

3.3309 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3309 mL	16.6545 mL	33.3089 mL	83.2723 mL
	5 mM	0.6662 mL	3.3309 mL	6.6618 mL	16.6545 mL
	10 mM	0.3331 mL	1.6654 mL	3.3309 mL	8.3272 mL

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Emodic acid

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Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen

Alle JNK Isoform-spezifische Produkte anzeigen

Alle VEGFR Isoform-spezifische Produkte anzeigen

Alle MMP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Emodic acid Related Classifications

HY-134000 Related Classifications