Protectin D1
Based on 1 Customer Validation
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders.
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- Pureté: 99.0%
- CAS No.: 660430-03-5
- Formule: C22H32O4
- Masse moléculaire:360.49
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Stockage:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Human Endogenous Metabolite |
IL-1β |
Protectin D1 (1 μM, 24h) exerts cardioprotective effects in primary neonatal rat cardiomyocytes by upregulating miRNA-210 expression and activating the PI3K/AKT signaling pathway[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary neonatal rat cardiomyocytes
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Concentration:1 μM
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Incubation Time:24h
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Result:Upregulated miRNA-210 expression.
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Cell Line:Primary neonatal rat cardiomyocytes
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Concentration:1 μM
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Incubation Time:24h
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Result:Increased p-AKT and HIF-1α protein levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:I/R-induced acute myocardial infarction (AMI) rat model, male Sprague Dawley rats (8 weeks old)[3]
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Dosage:0.5 μM/kg, 1 μM/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 3 days before surgery
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Result:Significantly reduced I/R-induced heart rate (HR), improved left ventricular ejection fraction (EF%) and fractional shortening (FS%), and reduced myocardial infarction area.
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Animal Model:Cecal ligation and puncture (CLP)-induced sepsis Wistar rat model (8 weeks old, 200 g)[4]
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Dosage:0.08 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose (12 hours before surgery)
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Result:Significantly reduced ROS concentration in hepatocytes of CLP-induced rats, decreased NALP3, ASC, and Caspase-1 expression levels, and lowered serum IL-18 and IL-1β concentrations.
Chemical Information
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CAS No. 660430-03-5
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Appearance Liquid
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Masse moléculaire 360.49
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Formule C22H32O4
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
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Synonyms
Neuroprotectin D1; NPD1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823. [Content Brief]
[2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859. [Content Brief]
[3]. Zhang P, et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J Cardiovasc Transl Res. 2024 Apr;17(2):376-387. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protectin D1 Related Classifications
HY-130413 Related Classifications
Powered by Bioz
- Protectin D1
- 660430-03-5
- Neuroprotectin D1
- NPD1
- Protectin D 1
- Protectin D-1
- Neuroprotectin D 1
- Neuroprotectin D-1
- NPD1
- NPD 1
- NPD-1
- Endogenous Metabolite
- PI3K
- Akt
- HIF/HIF Prolyl-Hydroxylase
- Reactive Oxygen Species (ROS)
- Caspase
- Interleukin Related
- MicroRNA
- neuroprotectin D1
- neural cell
- docosahexaenoic acid
- pro-resolving
- anti-inflammatory
- Inhibitor
- inhibitor
- inhibit