DHFR - dihydrofolate reductase Gene

Also Known as DYR; DHFR1; DHFRP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1719

About DHFR

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,626,226-80,654,983 (from NCBI)

This gene has 7 transcripts (splice variants), 326 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 21.2), lymph node (RPKM 18.2) and 24 other tissues.

Summary

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain Amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

DHFR Products (4)

mRNA	Protein	Name
NM_000791.4	NP_000782.1	dihydrofolate reductase isoform 1
NM_001290357.2	NP_001277286.1	dihydrofolate reductase isoform 3
NR_110936.2
NM_001290354.2	NP_001277283.1	dihydrofolate reductase isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables NADPH binding	IDA IDA: Inferred from direct assay	2303423	GOA
enables dihydrofolate reductase activity	IDA IDA: Inferred from direct assay	2303423	GOA
enables folic acid binding	IDA IDA: Inferred from direct assay	2303423	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21876184	GOA
enables mRNA regulatory element binding translation repressor activity	IDA IDA: Inferred from direct assay	8490020	GOA
enables sequence-specific mRNA binding	IDA IDA: Inferred from direct assay	8490020	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dihydrofolate metabolic process	IDA IDA: Inferred from direct assay	2303423	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	8490020	GOA
involved in tetrahydrobiopterin biosynthetic process	IMP IMP: Inferred from mutant phenotype	23707606	GOA
involved in tetrahydrofolate biosynthetic process	IDA IDA: Inferred from direct assay	2303423	GOA
involved in tetrahydrofolate metabolic process	IDA IDA: Inferred from direct assay	12096917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHFR Protein Structure

DHFR_1

0
100
187 a.a.

Protein Preferred Names	Protein Names
dihydrofolate reductase

Recombinant DHFR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79328	DHFR Protein, Human (His)	P00374-1 (M1-D187)	≥ 95%, as determined by reducing SDS-PAGE.

DHFR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83590	DHFR Antibody (YA3335)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Plasmodium Falciparum Malaria	Falciparum Malaria Malaria, Falciparum Malaria Fever, Subtertian Malignant Tertian Fever Malaria Falciparum Cerebral Malaria Nos Cerebral Malaria
Pneumocystosis	Pneumocystis Jirovecii Pneumonia Pneumocystis Carinii Pneumonia Pneumocystis Pneumonia Pulmonary Pneumocystosis PCP Pneumocystosis Pneumonia Pneumonia Pneumocystis Carinii Pneumonia, Pneumocystis Pneumocystis Jiroveci Pneumonia
Arthrogryposis, Distal, Type 1c	DA1C Distal Arthrogryposis Type 1c Arthrogryposis, Distal, 1c
Cryptosporidiosis	Cryptosporidial Gastroenteritis Intestinal Cryptosporidiosis Infection By Cryptosporidium Gastroenteritis Due To Cryptosporidium Cryptosporidial Infection
Subacute Leukemia
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency	Dhfr Deficiency Constitutional Megaloblastic Anemia With Severe Neurologic Disease Dihydrofolate Reductase Deficiency DHFRD Deficiency Of Dihydrofolate Reductase
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Candida Glabrata	Torulopsis Glabrata
Congenital Toxoplasmosis	Toxoplasmosis, Congenital Mother-To-Child Transmission Of Toxoplasmosis Toxoplasma Embryofetopathy Toxoplasma Embryopathy Toxoplasmosis - Congen. Toxoplasmosis Congenital
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Plasmodium Vivax Malaria	Malaria, Vivax Malaria By Plasmodium Vivax Vivax Malaria Malaria Vivax
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Folate Malabsorption, Hereditary	Hereditary Folate Malabsorption Congenital Defect Of Folate Absorption Congenital Folate Malabsorption Folic Acid Transport Defect HFM
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Ulcerative Stomatitis	Stomatitis Ulcerative Aphthous Stomatitis Minor Oral Aphthous Ulceration
Tumor Predisposition Syndrome	TPDS Tumor Predisposition
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency	Sepiapterin Reductase Deficiency Spr Deficiency Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency Srd Drd Due To Srd Dopa-Responsive Hypersomnia Dyt-Spr Dyt/Park-Spr Sr-Deficient Drd Autosomal Recessive Sepiapterin Reductase-Deficient Drd Spr DRDSPRD Motor And Cognitive Disorder Due To Sepiapterin Reductase Deficiency Psychomotor Disorders
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Charcot-Marie-Tooth Disease, Axonal, Type 2dd	CMT2DD Charcot-Marie-Tooth Neuropathy, Type 2dd Charcot-Marie-Tooth Disease Type 2dd Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Atp1a1-Related Cmt2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd Charcot-Marie-Tooth Disease 2dd
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancytopenia
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Tetrahydrobiopterin Deficiency	Hyperphenylalaninemia Due To Tetrahydrobiopterin Deficiency Hyperphenylalaninemia, Non-Phenylketonuric Non-Phenylketonuric Hyperphenylalaninemia Bh4 Deficiency Hyperphenylalaninemia Caused By A Defect In Biopterin Metabolism Hyperphenylalaninemia Due To Bh4 Deficiency
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Cutis Laxa, Autosomal Dominant 1	Cutis Laxa, Autosomal Dominant Autosomal Dominant Cutis Laxa ADCL1 Adcl Autosomal Dominant Cutis Laxa 1 Cutis Laxa, Autosomal Dominant, 1 Cutis Laxa, Autosomal Dominant, Type 1
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cystoisosporiasis	Isosporiasis Infection By Isospora Belli And Isospora Hominis Isosporosis Infection By Isospora Belli Or Isospora Hominis Isospora Belli Or Hominis Infection Coccidial Infestation Coccidiosis Coccidial Dysentery Intestinal Coccidiosis Nos
Holoprosencephaly 6	HPE6
Plasmodium Malariae Malaria	Quartan Malaria Malaria By Plasmodium Malariae Nephrotic Syndrome Of Quartan Malaria Malaria Nephrosis Malarial Nephrosis Nephrotic Syndrome In Malaria Quartan Nephrosis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Megaloblastic Anemia	Imerslund-Grasbeck Syndrome Igs Defect Of Enterocyte Intrinsic Factor Receptor Enterocyte Cobalamin Malabsorption Familial Megaloblastic Anemia Megaloblastic Anemia 1 Selective Cobalamin Malabsorption With Proteinuria Anemia, Megaloblastic Grasbeck-Imerslund Syndrome Megaloblastic Anaemia Mga1 Norwegian Type Recessive Hereditary Megaloblastic Anaemia 1 Recessive Hereditary Megaloblastic Anemia 1 Rh-Mga1 Gräsbeck-Imerslund Disease Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria Imerslund-Gräsbeck Syndrome Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12 Anemia Megaloblastic Megaloblastic Anemia Due To Inborn Errors Of Metabolism 3-@Methylglutaconic Aciduria, Type I
Chorioretinitis	Retinochoroiditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10820	Pemetrexed	Inducer	99.97%	Unkown
HY-10446	Pralatrexate	Inducer	99.23%	Yes
HY-10820A	Pemetrexed disodium	Inducer	99.79%	Unkown
HY-18062	Pyrimethamine		99.99%	Yes
HY-10373	Trimetrexate	Inhibitor	99.60%	Unkown
HY-B0806	Proguanil	Inhibitor	99.84%	Unkown
HY-13781	Pemetrexed disodium hemipenta hydrate	Inducer	99.78%	Unkown
HY-10820B	Pemetrexed disodium heptahydrate		99.97%	Unkown
HY-I0447	4-Aminosalicylic acid	Inhibitor	99.82%	Yes
HY-I0447A	Sodium 4-aminosalicylate dihydrate	Inhibitor	99.95%	Yes
HY-B0806A	Proguanil hydrochloride	Inhibitor	99.21%	Unkown
HY-10373A	Trimetrexate trihydrochloride	Inhibitor	/	Unkown
HY-10373B	Trimetrexate isethionate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14518	Aminopterin	Antagonist	99.33%	Phase 2
HY-106434	Piritrexim	Inhibitor	99.07%	Phase 2
HY-10824A	Talotrexin monoammonium	Inhibitor	/	Phase 2
HY-19095	TNP-351		/	Phase 2
HY-19885	AR-102	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (106)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116387	WR99210	Inhibitor	99.10%	Unkown
HY-12784A	Cycloguanil hydrochloride	Inhibitor	99.93%	Unkown
HY-N0913	Manninotriose	Modulator	99.97%	Unkown
HY-10824	Talotrexin		99.27%	Unkown
HY-W587663	4′-DTMP	Inhibitor	97.33%	Unkown
HY-116387A	WR99210 hydrochloride	Inhibitor	98.34%	Unkown
HY-107033	Tetroxoprim	Inhibitor	98.97%	Unkown
HY-162475	Fluorofolin	Inhibitor	99.85%	Unkown
HY-W003561	DHFR-IN-3	Inhibitor	99.48%	Unkown
HY-126316	Zapalog	Modulator	99.62%	Unkown
HY-RS03730	DHFR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18062S	Pyrimethamine-d3		99.90%	Unkown
HY-139743	Aditoprime	Inhibitor	99.68%	Unkown
HY-151159	DHFR-IN-4	Inhibitor	99.19%	Unkown
HY-B1902	Diaveridine		99.69%	Unkown
HY-137129	10-Formyl-7,8-dihydrofolic acid	Substrate	97.70%	Unkown
HY-153007	DHFR-IN-5	Inhibitor	99.27%	Unkown
HY-169790	Phomarin	Inhibitor	98.53%	Unkown
HY-137439	Fanotaprim		98.89%	Unkown
HY-12784	Cycloguanil	Inhibitor	/	Unkown
HY-12784S	Cycloguanil-d6	Inhibitor	98.0%	Unkown
HY-176557	NCI677397		/	Unkown
HY-B0806AS1	Proguanil-d6 hydrochloride	Inhibitor	98.73%	Unkown
HY-22252	4-Aminosalicylic acid hemicalcium	Inhibitor	/	Unkown
HY-12784AS	Cycloguanil-d4 hydrochloride	Inhibitor	/	Unkown
HY-10446S1	Pralatrexate-13C5,15N	Inducer	/	Unkown
HY-10820AS	Pemetrexed-d5 disodium	Inducer	/	Unkown
HY-10820S	Pemetrexed-d5		/	Unkown
HY-10824B	Talotrexin ammonium	Inhibitor	/	Unkown
HY-116039	Epiroprim	Inhibitor	/	Unkown
HY-117000	D156844	Agonist	/	Unkown
HY-117000A	D156844 hydrochloride	Agonist	/	Unkown
HY-117791	(R)-Pralatrexate	Control	/	Unkown
HY-121207	Denopterin	Inhibitor	/	Unkown
HY-122045	CB 3705	Inhibitor	/	Unkown
HY-122289	Metioprim	Inhibitor	/	Unkown
HY-12784AR	Cycloguanil hydrochloride (Standard)	Inhibitor	/	Unkown
HY-12784AS1	Cycloguanil-d6 hydrochloride	Inhibitor	/	Unkown
HY-12784S1	Cycloguanil-d6 nitrate	Inhibitor	/	Unkown
HY-137357	5-Monobutyl methotrexate	Inhibitor	/	Unkown
HY-143236	DHFR-IN-1	Inhibitor	/	Unkown
HY-147661	DHFR-IN-2	Inhibitor	/	Unkown
HY-149200	Lysine-methotrexate		/	Unkown
HY-149632	EGFR/HER2/DHFR-IN-2	Inhibitor	/	Unkown
HY-149633	EGFR/HER2/DHFR-IN-3		/	Unkown
HY-149958	Antileishmanial agent-17	Inhibitor	/	Unkown
HY-151154	EGFR/HER2/DHFR-IN-1	Inhibitor	/	Unkown
HY-151156	EGFR/HER2-IN-6		/	Unkown
HY-151158	EGFR/HER2-IN-7	Inhibitor	/	Unkown
HY-151161	EGFR/HER2-IN-8	Inhibitor	/	Unkown
HY-151458	VEGFR-2/DHFR-IN-1	Inhibitor	/	Unkown
HY-151459	VEGFR-2/DHFR-IN-2	Inhibitor	/	Unkown
HY-154807	DQn-1	Inhibitor	/	Unkown
HY-156122	DHFR-IN-8	Inhibitor	/	Unkown
HY-156123	DHFR-IN-9	Inhibitor	/	Unkown
HY-156859	NSC309401 dihydrochloride	Inhibitor	/	Unkown
HY-160254	1954U89	Inhibitor	/	Unkown
HY-162358	DHFR-IN-17	Inhibitor	/	Unkown
HY-163722	EGFR/DHFR-IN-1	Inhibitor	/	Unkown
HY-168648	DNA Gyrase/DHFR-IN-1	Inhibitor	/	Unkown
HY-168918	Insecticidal agent 19	Inhibitor	/	Unkown
HY-172897	EGFR/DHFR-IN-2		/	Unkown
HY-173220	DHFR-IN-23		/	Unkown
HY-178728	BION106		/	Unkown
HY-178759	DHFR-IN-5-amino-PEG3-C2-azido		/	Unkown
HY-183053	UCP1173	Inhibitor	/	Unkown
HY-183286	DHFR-IN-27	Inhibitor	/	Unkown
HY-185443	UCP1172	Inhibitor	/	Unkown
HY-B0806S1	Proguanil-d4		/	Unkown
HY-B1902S	Diaveridine-d6		/	Unkown
HY-E70522	Dihydrofolate reductase		/	Unkown
HY-I0447S	4-Aminosalicylic acid-d6		/	Unkown
HY-N10791	Neobritannilactone B		/	Unkown
HY-RS03731	Dhfr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03732	Dhfr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W769288	Pemetrexed disodium-13C5		/	Unkown
HY-Z15986	Methotrexate diethyl ester	Inhibitor	/	Unkown
HY-105714	Etoprine	Inhibitor	/	Unkown
HY-115836	DDPO	Inhibitor	/	Unkown
HY-118251	PD130883	Inhibitor	/	Unkown
HY-119613	Clociguanil	Inhibitor	/	Unkown
HY-143408	OYYF-175	Inhibitor	/	Unkown
HY-149699	DHFR-IN-12	Inhibitor	/	Unkown
HY-153007A	DHFR-IN-5 hydrochloride	Inhibitor	/	Unkown
HY-156412	DHFR-IN-10	Inhibitor	/	Unkown
HY-156414	DHFR-IN-11	Inhibitor	/	Unkown
HY-156859A	NSC309401	Inhibitor	/	Unkown
HY-159899	DHFR-IN-22	Inhibitor	/	Unkown
HY-161010	DHFR-IN-13	Inhibitor	/	Unkown
HY-161063	DHFR-IN-14	Inhibitor	/	Unkown
HY-161064	DHFR-IN-15	Inhibitor	/	Unkown
HY-161292	DHFR-IN-16	Inhibitor	/	Unkown
HY-162656	DHFR-IN-19	Inhibitor	/	Unkown
HY-163725	DHFR-IN-18	Inhibitor	/	Unkown
HY-168069	DHFR-IN-20	Inhibitor	/	Unkown
HY-169211	DHFR-IN-21		/	Unkown
HY-177337	N-Didesmethyladitoprim	Inhibitor	/	Unkown
HY-179415	DHFR-IN-24	Inhibitor	/	Unkown
HY-179493	DHFR-IN-25	Inhibitor	/	Unkown
HY-181100	DHFR-IN-26	Inhibitor	/	Unkown
HY-181813	PROTAC DHFR Degrader-1		/	Unkown
HY-181814	DHFR ligand-Linker Conjugate 1		/	Unkown
HY-182684	MMV675968	Inhibitor	/	Unkown
HY-B0806AS	Proguanil-d4 hydrochloride	Inhibitor	/	Unkown
HY-N3764	Diosbulbin C	Activator	/	Unkown
HY-W167448	DHFR-IN-28	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DHFR	RGD	RGD:2500
Mus musculus	DHFR	MGD	MGI:94890
Others	DHFR	NCBI