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Cat. No.: HY-10984S

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Pomalidomide-d₅

Name: Pomalidomide-d5
Brand: MedChemExpress
SKU: HY-10984S
Price: 854.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: CC-4047-d₅)

Pomalidomide-d₅ (CC-4047-d₅) is the deuterated-labeled Pomalidomide (HY-10984). Pomalidomide (CC-4047) is an immunomodulatory agent. Pomalidomide downregulates TNF-alpha, IL-1, IL-11, and IL-12, upregulates IL-2, IL-5, and IL-10, and costimulates T cells. Pomalidomide inhibits the proliferation of T regulatory cells by reducing FOXP3/OX-40 expression and IL-2-mediated expansion. Pomalidomide inhibits CDK2/4/6 and p21^WAF-1, causing cell cycle arrest. Pomalidomide can be used in research on myelofibrosis-associated anemia, multiple myeloma, and colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 1377838-49-7
Formula: C₁₃H₆D₅N₃O₄
Molecular Weight:278.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Pomalidomide-d₅ Chemical Structure

CAS No.: 1377838-49-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]^[4]

IL-1

TNF-alpha

IL-12

IL-2

IL-5

IL-10

IL-11

FOXP3

CDK2

OX-40

CDK4

CDK6

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All FOXP Isoforms :

FOXP3

All Orexin Receptor (OX Receptor) Isoforms :

All CDK Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1377838-49-7
Unlabeled CAS 19171-19-8
Molecular Weight 278.27
Formula C₁₃H₆D₅N₃O₄
SMILES

NC1=C2C(C(N(C2=O)C3(C(NC(C([2H])(C3([2H])[2H])[2H])=O)=O)[2H])=O)=CC=C1
Synonyms

CC-4047-d₅
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tefferi A, et al. Pomalidomide is active in the treatment of anemia associated with myelofibrosis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Sep 20;27(27):4563-9.

[2]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501. [Content Brief]

[3]. Galustian C, et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer immunology, immunotherapy : CII. 2009 Jul;58(7):1033-45.

[4]. Verhelle D, et al. Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer research. 2007 Jan 15;67(2):746-55.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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Pomalidomide-d₅

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All FOXP Isoforms

All Orexin Receptor (OX Receptor) Isoforms

All CDK Isoforms