Pgp - phosphoglycolate phosphatase Gene

Also Known as AUM; G3PP; RGD1307773

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287115

Summary

Enables glycerol-3-phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PGP (phosphoglycolate Phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Pgp Products (1)

mRNA Protein Name
NM_001169152.1 NP_001162623.1 glycerol-3-phosphate phosphatase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glycerol-3-phosphatase activity IMP
IMP: Inferred from mutant phenotype
26755581 RGD
Biological Process GO Annotation Evidence References Source
involved in glycerol biosynthetic process IDA
IDA: Inferred from direct assay
26755581 RGD
involved in glycerophospholipid metabolic process IMP
IMP: Inferred from mutant phenotype
26755581 RGD
involved in negative regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
26755581 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycerol-3-phosphate phosphatase

  • aspartate-based ubiquitous Mg(2+)-dependent phosphatase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14275 Verapamil 99.96% Yes
HY-A0064 Verapamil hydrochloride 99.98% Yes
HY-10440 Vismodegib 99.97% Yes
HY-B1751 Quinidine (15% dihydroquinidine) 98.36% Unkown
HY-17367 Atazanavir 99.13% Yes
HY-B0777 Moxidectin Inhibitor 99.32% Yes
HY-B1302 Quinidine hydrochloride monohydrate 99.97% Yes
HY-17367A Atazanavir sulfate 99.68% Yes
HY-145574 Iruplinalkib Inhibitor 99.62% Unkown
HY-B1180 Vinburnine 99.78% Unkown
HY-A0064R Verapamil hydrochloride (Standard) 99.81% Unkown
HY-B0168B Levomilnacipran hydrochloride 99.95% Unkown
HY-14275R Verapamil (Standard) 99.72% Unkown
HY-B0501 Danofloxacin mesylate Inhibitor 99.88% Unkown
HY-W001601 Budipine Antagonist 99.41% Unkown
HY-N7120 Penicillin G procaine hydrate Inhibitor 98.85% Unkown
HY-14794A Levomilnacipran / Unkown
HY-B0777R Moxidectin (Standard) Inhibitor / Unkown
HY-B1751A Quinidine sulfate / Unkown
HY-B1751E Quinidine polygalacturonate / Unkown
HY-B1751F Quinidine gluconic acid / Unkown
HY-B1751D Quinidine sulfate dihydrate / Unkown

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-109566 Elrelesertib 99.22% Phase 3
HY-15255 Zosuquidar Inhibitor 99.96% Phase 3
HY-17013A Dofequidar fumarate Inhibitor 98.0% Phase 3
HY-10550B Tariquidar dimesylate Inhibitor / Phase 3
HY-106004 Zamicastat Inhibitor 99.93% Phase 2
HY-14942 Berubicin 85.02% Phase 2
HY-132189 Laniquidar Inhibitor 99.42% Phase 2
HY-19642 Glesatinib Inhibitor / Phase 2
HY-119101 AZD-5672 95.74% Phase 2
HY-14942A Berubicin hydrochloride 95.08% Phase 2
HY-16773 Vedroprevir Inhibitor / Phase 2
HY-50879 Elacridar Inhibitor 99.66% Phase 1
HY-108286 Talinolol Antagonist 99.64% Phase 1
HY-50879R Elacridar (Standard) Inhibitor 97.50% Phase 1
HY-19405 UK-224671 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (185)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10010 Ko 143 Inhibitor 99.97% Unkown
HY-10550 Tariquidar Inhibitor 99.45% Yes
HY-N6684 Deoxynivalenol 99.90% Unkown
HY-50671 Zosuquidar trihydrochloride Inhibitor 99.50% Unkown
HY-50880 Elacridar hydrochloride Inhibitor 99.93% Unkown
HY-107643 Reversan Inhibitor 99.57% Unkown
HY-10550A Tariquidar methanesulfonate, hydrate Inhibitor 98.55% Yes
HY-13925 PD0166285 99.46% Unkown
HY-N0217 Benzoylaconine 99.92% Unkown
HY-108694 γ-Tocotrienol Inhibitor 99.73% Unkown
HY-N3584 Paris saponin VII 99.84% Unkown
HY-N1916 Coniferyl ferulate 98.73% Unkown
HY-N0248 Saikosaponin B2 99.98% Unkown
HY-N2453 Convallatoxin 99.72% Unkown
HY-100750 Norverapamil hydrochloride Inhibitor 99.80% Unkown
HY-N0419 Quercimeritrin 99.48% Unkown
HY-161246 uPSEM792 Agonist 98.02% Unkown
HY-126940 Furanodiene 99.83% Unkown
HY-D1005A25 Poloxamer 403 (P123) / Unkown
HY-19642A Glesatinib hydrochloride Inhibitor 98.01% Unkown
HY-N1941 Isosinensetin Inhibitor 99.90% Unkown
HY-D1005A10 Poloxamer 184 (L64) Inhibitor / Unkown
HY-N0566 23-Hydroxybetulinic acid 99.44% Unkown
HY-N2103 Tenacissoside G 99.64% Unkown
HY-W009141 1-Monopalmitin 99.89% Unkown
HY-117738 Benarthin Inhibitor 95.79% Unkown
HY-17013 Dofequidar Inhibitor 99.29% Unkown
HY-A0064S Verapamil-d3 hydrochloride 99.57% Unkown
HY-173162 GPV0057 99.20% Unkown
HY-N2416 Taccalonolide A 99.29% Unkown
HY-B0777S Moxidectin-d3 Inhibitor 95.71% Unkown
HY-D1005A23 Poloxamer 401 (L121) Inhibitor / Unkown
HY-D1005A8 Poloxamer 181 (L61) Inhibitor / Unkown
HY-N6015 Bacopasaponin C Inhibitor 99.76% Unkown
HY-119229 VRT-325 Modulator 99.58% Unkown
HY-119823 PGP-4008 Inhibitor 99.26% Unkown
HY-N3028 Taccalonolide B Inhibitor 99.46% Unkown
HY-N6932 Voacamine 99.64% Unkown
HY-RS00048 ABCB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113805 MC70 Inhibitor 99.33% Unkown
HY-N4108 Hypophyllanthin Inhibitor 98.84% Unkown
HY-W035709 Hydrocinchonine 98.33% Unkown
HY-N6748 Roquefortine C 98.03% Unkown
HY-19626 NSC23925 Inhibitor 99.43% Unkown
HY-101791 P-gp inhibitor 1 Inhibitor 98.79% Unkown
HY-132866 YS-370 Inhibitor 98.07% Unkown
HY-155391 hCA/Wnt/β-catenin-IN-1 Inhibitor 99.96% Unkown
HY-176557 NCI677397 / Unkown
HY-W777317 Elacridar-d4(Major) / Unkown
HY-Z15823 (R)-Verapamil 98.97% Unkown
HY-108286A (-)-Talinolol 99.26% Unkown
HY-141425 NSC73306 98.52% Unkown
HY-162373 α-Amylase/α-Glucosidase-IN-10 Inhibitor / Unkown
HY-110377 Tariquidar dihydrochloride Inhibitor / Unkown
HY-112912 P-gp modulator 1 / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128685 FD 12-9 Inhibitor / Unkown
HY-146096 RMS3 / Unkown
HY-146097 RMS5 / Unkown
HY-149053 OY-101 Inhibitor / Unkown
HY-17367S2 Atazanavir-d9 / Unkown
HY-17367S3 Atazanavir-d5 / Unkown
HY-106753 Tolnapersine / Unkown
HY-108286S (Rac)-Talinolol-d5 Antagonist / Unkown
HY-116976 NSC-57969 / Unkown
HY-117593 NSC 23925B Inhibitor / Unkown
HY-118083 Pentamethoxymorin Inhibitor / Unkown
HY-120790 S 16317 / Unkown
HY-121247 Bromotetrandrine Inhibitor / Unkown
HY-123384 KR30031 Inhibitor / Unkown
HY-135328AS Norverapamil-d7 hydrochloride Antagonist 98.86% Unkown
HY-135328S Norverapamil-d7 Inhibitor / Unkown
HY-13774 WK-X-34 Inhibitor / Unkown
HY-13925A PD0166285 dihydrochloride / Unkown
HY-14275S1 Verapamil-d7 / Unkown
HY-144366 P-gp inhibitor 3 Inhibitor / Unkown
HY-144393 P-gp/BCRP-IN-1 Inhibitor / Unkown
HY-146117 P-gp modulator 2 Modulator / Unkown
HY-146118 P-gp modulator 3 Modulator / Unkown
HY-146391 P-gp inhibitor 4 Modulator / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-14794AS Levomilnacipran-d10 hydrochloride / Unkown
HY-149053B (R)-OY-101 / Unkown
HY-149240 Anticancer agent 108 Inhibitor / Unkown
HY-149277 FM04 Inhibitor 99.86% Unkown
HY-149360 P-gb-IN-1 Inhibitor / Unkown
HY-149813 P-gp inhibitor 14 Inhibitor / Unkown
HY-149981 P-gp inhibitor 13 Inhibitor / Unkown
HY-150565 P-gp inhibitor 5 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-155032 P-gp inhibitor 15 Inhibitor / Unkown
HY-157330 P-gp inhibitor 16 / Unkown
HY-157483 P-gp inhibitor 18 Inhibitor / Unkown
HY-157484 P-gp inhibitor 19 Inhibitor / Unkown
HY-157876 Anticancer agent 191 Inhibitor / Unkown
HY-158236 ORL1 antagonist 2 Antagonist / Unkown
HY-158429 PROTAC CYP1B1 degrader-2 / Unkown
HY-158435 P-gp inhibitor 23 Inhibitor / Unkown
HY-159085 P-gp inhibitor 24 Inhibitor / Unkown
HY-159935 Top1-IN-2 Inhibitor / Unkown
HY-161260 P-gp inhibitor 20 Inhibitor / Unkown
HY-161645 P-gp modulator-4 Modulator / Unkown
HY-161776 P-gp/CDK2-IN-1 Inhibitor / Unkown
HY-162040 P-gp inhibitor 17 Inhibitor / Unkown
HY-162369 PID-9 Inhibitor / Unkown
HY-162396 P-gp inhibitor 21 Inhibitor / Unkown
HY-162447 P-gp inhibitor 22 / Unkown
HY-16265A JI-101 hydrochloride Inhibitor / Unkown
HY-162822 P-gp modulator-5 Modulator / Unkown
HY-163204 RhQ-DMB Inhibitor / Unkown
HY-165491 R 101933 Inhibitor / Unkown
HY-165606 SB-T-1214 Inducer / Unkown
HY-168008 P-gp inhibitor 25 Inhibitor / Unkown
HY-168186 P-gp inhibitor 26 Inhibitor / Unkown
HY-168711 P-gp inhibitor 27 Inhibitor / Unkown
HY-168953 Lysosomal P-gp targeted agent 1 / Unkown
HY-17013D Dofequidar sesquifumarate Inhibitor / Unkown
HY-172365 P7–2302 Inhibitor / Unkown
HY-173182 Antitumor agent-200 Inhibitor / Unkown
HY-173222 P-gp inhibitor 28 Inhibitor / Unkown
HY-173401 P-gp inhibitor 29 Inhibitor / Unkown
HY-17367S4 Atazanavir-d6 99.28% Unkown
HY-174223 α-Glucosidase-IN-90 Inhibitor / Unkown
HY-174324 VEGFR-2/P-gp-IN-1 / Unkown
HY-175206 P-gp-IN-30 Inhibitor / Unkown
HY-175522 P-gp-IN-31 / Unkown
HY-175838 P-gp-IN-32 Inhibitor / Unkown
HY-176193 P-gp modulator-7 Inhibitor / Unkown
HY-176421 PROTAC PI3K/110β degrader-1 / Unkown
HY-17648 MBL-II-141 Inhibitor / Unkown
HY-178349 P-gp inhibitor 30 / Unkown
HY-178466 Tubulin polymerization/P-gp-IN-1 / Unkown
HY-179683 MRP1-IN-2 Inhibitor / Unkown
HY-180282 P-gp-IN-33 Inhibitor / Unkown
HY-181252 P-gp-IN-35 Inhibitor / Unkown
HY-181773 P-gp-IN-36 Inhibitor / Unkown
HY-181889 KRAS G12C-IN-75 Inhibitor / Unkown
HY-182753 Tubulin-IN-66 / Unkown
HY-183143 Lss-11 / Unkown
HY-184469 DVL1/P-gp-IN-1 / Unkown
HY-184489 PGP/FSP1-IN-1 / Unkown
HY-A0064S1 Verapamil-d6 hydrochloride / Unkown
HY-B0168BS Levomilnacipran-d5 hydrochloride / Unkown
HY-B1751S Quinidine-d3 / Unkown
HY-B1751S1 Quinidine-13C, d2 hydrochloride / Unkown
HY-D1005A9 Poloxamer 183 (L63) Inhibitor / Unkown
HY-N10342 Cajanol / Unkown
HY-N13157 11α-O-Benzoyl-12β-O-acetyltenacigenin B Inhibitor / Unkown
HY-N144114 P-gp inhibitor 2 Inhibitor / Unkown
HY-N15636 Coccinine Inhibitor / Unkown
HY-N16684 Clausarin Inhibitor / Unkown
HY-N6748S Roquefortine C-13C22 / Unkown
HY-N7917 Tenacigenoside A / Unkown
HY-RS10394 PGP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10395 PGPEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W009141S 1-Monopalmitin-d31 / Unkown
HY-W115674 Quinidine hydrochloride / Unkown
HY-W140488 1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine / Unkown
HY-W286423 L-Pyroglutamic acid 7-amido-4-methylcoumarin Substrate / Unkown
HY-W700684 N-Didesmethyl Loperamide / Unkown
HY-107197 8-Prenylchrysin Inhibitor / Unkown
HY-109566R Elrelesertib (Standard) / Unkown
HY-111175 IG-105 / Unkown
HY-123934 VU6007477 Modulator / Unkown
HY-129698 MS-073 Inhibitor / Unkown
HY-135328 Norverapamil Inhibitor / Unkown
HY-13646B Encequidar hydrochloride Inhibitor / Unkown
HY-14275S Verapamil-d3 / Unkown
HY-14275S2 Verapamil-d6 / Unkown
HY-164585 P-gp modulator-6 Modulator / Unkown
HY-169782 CJZ3 Inhibitor / Unkown
HY-17367S5 Atazanavir-d24 / Unkown
HY-179612 SARS-CoV-2 3CLpro-IN-34 Inhibitor / Unkown
HY-B1180A Vinburnine phosphate / Unkown
HY-N7305 Jatrophane 5 Inhibitor / Unkown
HY-N7332 Pepluanin A Inhibitor / Unkown
HY-RS17045 Pgp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23489 Pgp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W001601A Budipine hydrochloride Antagonist / Unkown
HY-W035709R Hydrocinchonine (Standard) / Unkown
HY-W699430 Norverapamil-d6 hydrochloride Inhibitor / Unkown
HY-W705354 Vismodegib-d4 / Unkown
HY-W716916 Vismodegib-d7 / Unkown
HY-W854295 Phosphatidylinositol-1,2-dioctanoyl sodium Inhibitor / Unkown
HY-U00247 MCI826 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgp NCBI NCBI:283871