2. Gene
  3. Mmp1 - matrix metallopeptidase 1 Gene

Mmp1 - matrix metallopeptidase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Clgn; MMP-1; Mmp1a

Gene ID: 300339 | Gene type: protein coding

About Mmp1

Primary_assembly 8: 4,658,588-4,679,097 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 308 orthologues, 23 paralogues and is associated with 100 phenotypes. Biased expression in Adrenal (RPKM 1.), Spleen (RPKM 1.) and 4 other tissues.

Summary

Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ Cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system Cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mmp1 Products(1)

mRNA Protein Name
NM_001134530.1 NP_001128002.1 interstitial collagenase precursor

Mmp1 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (25 - 83)

Peptidase_M10

Peptidase_M10: pfam00413 (104 - 258)

HX

HX: cd00094 (272 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

interstitial collagenase

fibroblast collagenase

matrix metallopeptidase 1a

matrix metalloproteinase 1

matrix metalloproteinase 1a (interstitial collagenase)

myocardial collagenase

Related Agents

Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-B2162A Chondroitin sulfate sodium (from shark cartilage) ≥99.0% Phase 4
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat ≥98.0% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-N0262 Cordycepin 99.17% Phase 2
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-19485 XL-784 98.13% Phase 2
HY-101671 S-methyl-KE-298 ≥98.0% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (49)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15768 Ilomastat Inhibitor 98.33% Yes
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-113952 Actinonin 98.61% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.71% Unkown
HY-100211 TAPI-2 Inhibitor 99.46% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-100359 CL-82198 Inhibitor 99.78% Unkown
HY-N1463 Luteolin 7-O-glucuronide 99.80% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-P4931 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 99.87% Unkown
HY-N1981 Triolein Inhibitor ≥98.0% Unkown
HY-107428 PD-166793 Inhibitor 99.45% Unkown
HY-13102 UK-383367 Inhibitor 99.92% Unkown
HY-151540 MMP-7-IN-1 Inhibitor 99.68% Unkown
HY-N6013 Aloin(mixture of A&B) Inhibitor 99.91% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-152092 MMP-1-IN-1 Inhibitor 99.10% Unkown
HY-N5072 Desmethylglycitein Inhibitor 98.98% Unkown
HY-N1981S Triolein-13C3 Inhibitor ≥98.0% Unkown
HY-W127716 Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 ≥97.0% Unkown
HY-124029 BI-4394 Inhibitor 99.91% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-122624 MMP13-IN-2 Inhibitor 99.85% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.90% Unkown
HY-N3387 Licoricidin ≥98.0% Unkown
HY-100211A (R)-TAPI-2 / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-119423 MMP Inhibitor II Inhibitor / Unkown
HY-121096 Funalenone Inhibitor / Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor / Unkown
HY-14240 PG 116800 Inhibitor / Unkown
HY-162131 Antitumor agent-132 / Unkown
HY-162453 Anticancer agent 204 / Unkown
HY-N12653 Exserohilone Inhibitor / Unkown
HY-N1981S1 Triolein-d5 Inhibitor / Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08516 MMP1 Human Pre-designed siRNA Set A / Unkown
HY-RS08517 Mmp1 Rat Pre-designed siRNA Set A / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-116302 MMP-9-IN-9 Inhibitor / Unkown
HY-118157 3,5,7-Trimethoxyflavone / Unkown
HY-13564A Batimastat sodium salt Inhibitor / Unkown
HY-N12150 Isozedoarondiol Inhibitor / Unkown
HY-W745164 3,3′-Bisdemethylpinoresinol Inhibitor / Unkown
HY-N1190 DL-Syringaresinol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp1 NCBI NCBI:4312
Mus musculus Mmp1 NCBI