Mmp1 - matrix metallopeptidase 1 Gene

Also Known as Clgn; MMP-1; Mmp1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300339

About Mmp1

Primary_assembly 8: 4,658,588-4,679,097 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 308 orthologues, 23 paralogues and is associated with 100 phenotypes. Biased expression in Adrenal (RPKM 1.), Spleen (RPKM 1.) and 4 other tissues.

Summary

Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ Cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system Cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mmp1 Products (1)

mRNA Protein Name
NM_001134530.1 NP_001128002.1 interstitial collagenase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
8531210 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21846328 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to alkaloid IEP
IEP: Inferred from expression pattern
21108488 RGD
involved in cellular response to fluid shear stress IEP
IEP: Inferred from expression pattern
19880665 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
22410640 RGD
involved in cellular response to iron(III) ion IEP
IEP: Inferred from expression pattern
21683124 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21683124 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
21811993 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
20564215 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
22410640 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
22064970 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19847888 RGD
involved in luteinization IEP
IEP: Inferred from expression pattern
8835383 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
8835383 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
19465549 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
19465549 RGD
involved in response to inactivity IEP
IEP: Inferred from expression pattern
20826544 RGD
involved in response to indole-3-methanol IEP
IEP: Inferred from expression pattern
20880187 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21488874 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23325540 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
22410640 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp1 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (25 - 83)

Peptidase_M10

Peptidase_M10: pfam00413 (104 - 258)

HX

HX: cd00094 (272 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

interstitial collagenase

  • fibroblast collagenase

  • matrix metallopeptidase 1a

  • matrix metalloproteinase 1

  • matrix metalloproteinase 1a (interstitial collagenase)

  • myocardial collagenase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108910 Chymotrypsin Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-101671 S-methyl-KE-298 98.0% Phase 4
HY-12169 Marimastat Inhibitor 99.90% Phase 3
HY-12170 Prinomastat 98.41% Phase 3
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-N0262 Cordycepin 99.80% Phase 2
HY-10398 CTS-1027 Inhibitor 99.24% Phase 2
HY-171804 Linvemastat Inhibitor 98.30% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (115)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-154919 DC-Y13-27 99.52% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.82% Unkown
HY-113952 Actinonin 98.37% Unkown
HY-N1981 Triolein Inhibitor 99.00% Unkown
HY-P4931 Mca-KPLGL-Dap(Dnp)-AR-NH2 99.30% Unkown
HY-100211 TAPI-2 Inhibitor 97.41% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-B2162A Chondroitin sulfate sodium (from shark cartilage) 99.52% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-100359 CL-82198 Inhibitor 99.89% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-164159 α-Glucosylrutin Inhibitor 96.32% Unkown
HY-N3266 Methyl rosmarinate 99.89% Unkown
HY-124029 BI-4394 Inhibitor 99.09% Unkown
HY-108910A Chymotrypsin (MS grade) Inhibitor / Unkown
HY-122624 MMP13-IN-2 Inhibitor 99.13% Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic 98.83% Unkown
HY-113440 5-Methoxytryptophol 99.95% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-N5072 Desmethylglycitein Inhibitor 99.99% Unkown
HY-152092 MMP-1-IN-1 Inhibitor 99.97% Unkown
HY-NP113 Highly purified Type II collagen, from chick sternal cartilage 99.00% Unkown
HY-N1981S1 Triolein-d5 Inhibitor 97.0% Unkown
HY-W127716 Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 97.78% Unkown
HY-116302 MMP-9-IN-9 Inhibitor 99.26% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.68% Unkown
HY-N0363 (+)-Columbianetin 99.04% Unkown
HY-107428 PD-166793 Inhibitor 99.21% Unkown
HY-117970 MMPI-1154 Inhibitor 99.76% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-N1981S Triolein-13C3 Inhibitor 98.00% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-N0363A (+)-Columbianetin acetate 99.83% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-118157 3,5,7-Trimethoxyflavone Inhibitor 98.86% Unkown
HY-143657 Myoferlin inhibitor 1 Inhibitor 99.88% Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA 99.78% Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-N3387 Licoricidin 98.00% Unkown
HY-NP109 Highly purified type I collagen, from mouse skin 99% Unkown
HY-164826 Acetyl zingerone 99.34% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-177590 14-3-3-IN-2 Inhibitor 98.41% Unkown
HY-W745164 3,3′-Bisdemethylpinoresinol Inhibitor 98.96% Unkown
HY-122106 RS-104966 Inhibitor 98.39% Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor 98.0% Unkown
HY-NP103 Highly purified Type III collagen, from bovine skin 90.0% Unkown
HY-NP126 Highly purified Type XI collagen, from porcine articular cartilage 90% Unkown
HY-P10775A BT1769 acetate Inhibitor / Unkown
HY-N1190 DL-Syringaresinol Inhibitor 96% Unkown
HY-183626 PAI-1-IN-1 99.45% Unkown
HY-100211A (R)-TAPI-2 Control / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114900 BB-3497 / Unkown
HY-115373 RO314724 Inhibitor / Unkown
HY-119138 R-130823 Inhibitor / Unkown
HY-121096 Funalenone Inhibitor / Unkown
HY-125507 F81-1144b Inhibitor / Unkown
HY-126956 Porphyra 334 99.58% Unkown
HY-137839 Anti-inflammatory agent 121 Inhibitor / Unkown
HY-15668 ST09 / Unkown
HY-162131 Antitumor agent-132 / Unkown
HY-162453 Anticancer agent 204 / Unkown
HY-175276 JNK-IN-24 Inhibitor / Unkown
HY-181769 Anticancer agent 306 / Unkown
HY-183378 RP 59794 Inhibitor / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-N12653 Exserohilone Inhibitor / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-N1981S2 Triolein-13C3-1 / Unkown
HY-NP104 Highly purified Type V collagen, from bovine amnion / Unkown
HY-NP105 Highly purified Type IX collagen, from bovine articular cartilage / Unkown
HY-NP106 Highly purified Type XI collagen, from bovine articular cartilage / Unkown
HY-NP107 Highly purified Type I collagen, from rat skin / Unkown
HY-NP108 Highly purified type II collagen, from rat sternal cartilage / Unkown
HY-NP110 Highly purified Type II collagen, from mouse sternal cartilage / Unkown
HY-NP111 Highly purified Type V collagen, from mouse intestine / Unkown
HY-NP112 Highly purified Type I collagen, from chick skin / Unkown
HY-NP114 Highly purified Type IX collagen, from chick articular cartilage / Unkown
HY-NP115 Highly purified Type XI collagen, from chick articular cartilage / Unkown
HY-NP122 Highly purified Type I collagen, from porcine skin / Unkown
HY-NP123 Highly purified Type II collagen, from porcine articular cartilage / Unkown
HY-NP124 Highly purified Type III collagen, from porcine skin / Unkown
HY-NP125 Highly purified Type IX collagen, from porcine articular cartilage / Unkown
HY-NP127 Highly purified Type I collagen, from canine skin / Unkown
HY-NP128 Highly purified Type I collagen, from rabbit skin / Unkown
HY-NP129 Highly purified Type II collagen, from sheep articular cartilage / Unkown
HY-NP130 Highly purified Type II collagen, from goat articular cartilage / Unkown
HY-P10043 MMP-1 Substrate Substrate / Unkown
HY-P10775 BT1769 Antagonist / Unkown
HY-P2608 DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4123 TAT (47-57) GGG-Cys(Npys) Inhibitor / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08516 MMP1 Human Pre-designed siRNA Set A / Unkown
HY-RS08517 Mmp1 Rat Pre-designed siRNA Set A / Unkown
HY-RS08526 Mmp13 Mouse Pre-designed siRNA Set A / Unkown
HY-W095774 (E)-N-(3-Methoxyphenyl)cinnamamide Inhibitor / Unkown
HY-W782935 MAPKAPK5-IN-1 / Unkown
HY-113440R 5-Methoxytryptophol (Standard) / Unkown
HY-123130 ABT-770 Inhibitor / Unkown
HY-152092A (R,R)-MMP-1-IN-1 98.00% Unkown
HY-N0363AR (+)-Columbianetin acetate (Standard) / Unkown
HY-N0363R (+)-Columbianetin (Standard) / Unkown
HY-N11072 Tremulacin Inhibitor 96.41% Unkown
HY-N1151 Thunberginol C Inhibitor / Unkown
HY-N12150 Isozedoarondiol Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown
HY-W1057938 (E)-N-(4-Methoxyphenyl)cinnamamide Inhibitor / Unkown
HY-W1058004 (E)-N-(2-Fluorophenyl)cinnamamide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp1 NCBI NCBI:4312