MMP1 - matrix metallopeptidase 1 Gene

Also Known as CLG; CLGN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4312

About MMP1

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,789,919-102,798,160 (from NCBI)

This gene has 4 transcripts (splice variants), 313 orthologues, 23 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 49.1), appendix (RPKM 17.7) and 7 other tissues.

Summary

This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

MMP1 Products (2)

mRNA	Protein	Name
NM_001145938.2	NP_001139410.1	interstitial collagenase isoform 2
NM_002421.4	NP_002412.1	interstitial collagenase isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	19022250	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	9920899	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	23845380	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to UV-A	IDA IDA: Inferred from direct assay	31380578	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19022250	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	15863497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP1 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
469 a.a.

Protein Preferred Names	Protein Names
interstitial collagenase	fibroblast collagenase matrix metallopeptidase 1 (interstitial collagenase) matrix metalloprotease 1

Recombinant MMP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70250	MMP-1 Protein, Human (HEK293, His, solution)	P03956 (F20-N469)	≥ 95%, as determined by reducing SDS-PAGE.

MMP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80754	MMP-1 Antibody	WB, IP	Human
HY-P80754A	MMP-1 Antibody (YA3394)	WB, FC, ICC/IF, IHC-P	Human
HY-P84006	MMP1 Antibody (YA3703)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84006A	MMP1 Antibody (YA3703)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P85280	MMP-1 Antibody (YA4972)	WB	Human

Related Diseases

Diseases	Alias
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Infiltrative Basal Cell Carcinoma	Skin Infiltrating Basal Cell Carcinoma
Chorioamnionitis
Atrioventricular Block	Av Block
Venous Insufficiency	Peripheral Venous Insufficiency
Scleredema Adultorum	Scleredema Buschke'S Scleredema Scleredema Adultorum Of Buschke Scleredema Diabeticorum Scleredema Diabeticorum Of Buschke Buschke Scleredema
Gingival Disease	Gingival Diseases Gum Disease Gingival Disorder Gingivitis And Periodontal Diseases
Pyoderma Gangrenosum	Phagedenic Pyoderma Phagedena Geometric
Gastroschisis	Laparoschisis Congenital Fissure Of The Abdominal Cavity Abdominal Wall Defect Abdominal Hernia Hernia, Abdominal Omphalocele Abnormality Of The Abdominal Wall Congenital Omphalocele Coeloschisis Coelioschisis Celoschisis Congenital Para-Umbilical Hernia
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Pelvic Organ Prolapse	Rectal Prolapse Pelvic Organ Prolapse, Susceptibility To Pelvic Organ Prolapse, Susceptibility To, 1 Prolapse Of Vagina And Rectum Vaginal Prolapse Pelvic Organ Prolapse 1 Procidentia, Rectum Prolapse Of Rectal Mucosa Procidentia Of Rectum Rectal Mucosa Prolapse Rectum Prolapse Procidentia Rectum Rp - [Rectal Prolapse] Male Proctocele Male Rectocele Proctoptosis Female Genital Prolapse Female Prolapse Incompetence Of Pelvic Fundus Relaxation Of Perineum Deficiency Of Perineum
Tendinopathy
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Fasciitis
Keratoconjunctivitis
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Smooth Muscle Tumor
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Chondrocalcinosis	Pseudogout Calcium Pyrophosphate Deposition Disease Familial Chondrocalcinosis Chondrocalcinosis Nos Cppd - [Calcium Pyrophosphate Deposition Disease] Cpdd - [Calcium Pyrophosphate Deposition Disease] Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site Chondrocalcinosis, Cause Unspecified Chondrocalcinosis Due To Pyrophosphate Crystals Chondrocalcinosis Articularis Calcium Pyrophosphate Arthritis And Periarthritis
Spastic Entropion
Bone Deterioration Disease
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]
Chronic Ulcer Of Skin	Chronic Wounds Callous Ulcer Indolent Ulcer Chronic Ulcer
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Aggressive Periodontitis	Juvenile Periodontitis Periodontitis, Juvenile Prepubertal Periodontitis
Pulmonary Fibrosis	Fibrosis Of Lung
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Frozen Shoulder	Adhesive Capsulitis Of Shoulder Bursitis Adhesions-Capsulitis,Shoulder Pericapsulitis Of Shoulder Duplay Bursitis Adhesive Shoulder Peritendinitis Subscapular Adhesion Shoulder Adhesion Adhesive Enthesopathy Of Shoulder Region Adhesive Peritendinitis Adhesive Shoulder Tenosynovitis Duplay Periarthritis Adhesive Shoulder Tendinitis
Osteomyelitis
Recessive Dystrophic Epidermolysis Bullosa	Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Rdeb Generalisata Gravis Rdeb, Severe Generalized Rdeb-Sev Gen Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized Hallopeau-Siemens Disease
Gingivitis	Chronic Gingivitis Acute Gingivitis
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Oral Lichen Planus	Oral Lichenoid Lesions Lichen Planus Oral Lichen Planus, Oral
Back Pain
Hypertensive Heart Disease
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Corneal Edema	Corneal Oedema Infiltrate Of Cornea
Exfoliation Syndrome	Pseudoexfoliation Glaucoma Pseudoexfoliation Syndrome Exfoliation Syndrome, Susceptibility To XFS Exfoliation Glaucoma Xfg Pseudoexfoliation Of The Lens Pexg Pexs Exfoliative Syndrome Glaucoma Capsulare Pex Pseudo-Exfoliation Syndrome
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Pyoderma
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Diabetes Mellitus	Diabetes
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Alpha-1-Antitrypsin Deficiency	Alpha 1-Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Aat Deficiency Aatd A1ATD Emphysema Due To Aat Deficiency A1at Deficiency Hemorrhagic Diathesis Due To Antithrombin Pittsburgh Emphysema-Cirrhosis, Due To Aat Deficiency Alpha-1 Antiprotease Deficiency Alpha 1 Antitrypsin Deficiency Aat Alpha-1 Protease Inhibitor Deficiency Alpha-1 Related Emphysema Genetic Emphysema Hereditary Pulmonary Emphysema Inherited Emphysema Alpha-1-Proteinase Inhibitor Deficiency Alpha1-Antitrypsin Deficiency Alpha-1-Antitrypsin Deficiency, Autosomal Recessive Emphysema, Hereditary Pulmonary Aatd - [Alpha-1-Antitrypsin] Deficiency
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Fibromatosis, Gingival, 1	GINGF1 Ggf1 Fibromatosis, Gingival, Hereditary Hgf Hereditary Gingival Fibromatosis Gingf Gingival Fibromatosis, 1 Fibromatosis Gingival, Hereditary, 1 Hgf1 Hereditary Gingival Fibromatosis, 1
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Conjunctivochalasis
Acne	Acne Vulgaris Acne Varioliformis Frontalis Acne
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Periodontitis	Chronic Pericementitis Chronic Periodontitis
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Periodontitis, Chronic	Chronic Periodontitis Periodontitis, Adult
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Pulmonary Emphysema
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Epidermolysis Bullosa Dystrophica, Autosomal Recessive	Epidermolysis Bullosa Dystrophica, Autosomal Recessive, Modifier Of RDEB Epidermolysis Bullosa Dystrophica, Hallopeau-Siemens Type Ebr1 Epidermolysis Bullosa Dystrophica, Generalized Severe, Autosomal Recessive Ebd Inversa Dystrophic Epidermolysis Bullosa, Autosomal Recessive Epidermolysis Bullosa Dystrophica, Ar Recessive Dystrophic Epidermolysis Bullosa Inversa Rdeb Inversa Rdeb-I Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Generalized Rdeb, Severe Form Rdeb Generalisata Gravis Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Autosomal Recessive Dystrophic Epidermolysis Bullosa Hallopeau-Siemens Disease
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Synovitis
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Carotid Stenosis	Carotid Artery Stenosis Stenosis, Carotid Artery
Polyhydramnios
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Periodontitis, Aggressive, 1	Ppp Pustulosis Palmaris Et Plantaris Periodontitis, Juvenile Localized Pustular Psoriasis Jpd Periodontitis 1, Juvenile Lpp Palmoplantar Pustulosis Prepubertal Periodontitis Periodontitis, Aggressive 1 Periodontitis, Prepubertal Periodontititis, Aggressive, 1 AP1 Juvenile Periodontitis Periodontitis Juvenile Pustulosis Of Palms And Soles Generalized Pustular Psoriasis
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Pulpitis	Pulp Stones Pulpitis Nos
Spinal Stenosis	Lumbar Spinal Stenosis Cervical Spinal Stenosis Spinal Stenosis Of Lumbar Region Spinal Stenosis In Cervical Region Spinal Canal Stenosis
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Localized Scleroderma	Morphea Localised Scleroderma Localized Fibrosing Scleroderma Circumscribed Scleroderma Localised Morphea Localised Morphoea Localized Morphea Scleroderma, Circumscribed Or Localised Scleroderma, Circumscribed Or Localized Scleroderma, Localized
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Gingival Fibromatosis	Hereditary Gingival Fibromatosis Hereditary Gingival Hyperplasia Autosomal Dominant Gingival Fibromatosis Autosomal Dominant Gingival Hyperplasia Fibromatosis, Gingival, Hereditary Fibromatosis, Gingival
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108910	Chymotrypsin	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3
HY-12170	Prinomastat		98.41%	Phase 3
HY-12170A	Prinomastat hydrochloride		98.53%	Phase 3
HY-15768	Ilomastat	Inhibitor	99.14%	Phase 2
HY-N0262	Cordycepin		99.80%	Phase 2
HY-10398	CTS-1027	Inhibitor	99.24%	Phase 2
HY-108910A	Chymotrypsin (MS grade)	Inhibitor	/	Phase 2
HY-101671	S-methyl-KE-298		98.0%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (110)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-154919	DC-Y13-27		99.52%	Unkown
HY-135232	MMP-9-IN-1	Inhibitor	99.82%	Unkown
HY-113952	Actinonin		98.37%	Unkown
HY-N1981	Triolein	Inhibitor	99.00%	Unkown
HY-P4931	Mca-KPLGL-Dap(Dnp)-AR-NH2		99.30%	Unkown
HY-100211	TAPI-2	Inhibitor	97.41%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-B2162A	Chondroitin sulfate sodium (from shark cartilage)		99.52%	Unkown
HY-N1463	Luteolin 7-O-glucuronide	Inhibitor	99.98%	Unkown
HY-100359	CL-82198	Inhibitor	99.89%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-164159	α-Glucosylrutin	Inhibitor	96.32%	Unkown
HY-N3266	Methyl rosmarinate		99.89%	Unkown
HY-124029	BI-4394	Inhibitor	99.09%	Unkown
HY-122624	MMP13-IN-2	Inhibitor	99.13%	Unkown
HY-P2179	MMP-1/MMP-9 Substrate, Fluorogenic		98.83%	Unkown
HY-113440	5-Methoxytryptophol		99.95%	Unkown
HY-119423	MMP Inhibitor II	Inhibitor	99.7%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	99.99%	Unkown
HY-152092	MMP-1-IN-1	Inhibitor	99.97%	Unkown
HY-NP113	Highly purified Type II collagen, from chick sternal cartilage		99.00%	Unkown
HY-N1981S1	Triolein-d5	Inhibitor	97.0%	Unkown
HY-W127716	Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2		97.78%	Unkown
HY-116302	MMP-9-IN-9	Inhibitor	99.26%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-128026	MMP-9/MMP-13 Inhibitor I	Inhibitor	99.68%	Unkown
HY-N0363	(+)-Columbianetin		99.04%	Unkown
HY-107428	PD-166793	Inhibitor	99.21%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.76%	Unkown
HY-N1981S	Triolein-13C3	Inhibitor	98.00%	Unkown
HY-19485	XL-784	Inhibitor	98.25%	Unkown
HY-N0363A	(+)-Columbianetin acetate		99.83%	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-118157	3,5,7-Trimethoxyflavone	Inhibitor	98.86%	Unkown
HY-143657	Myoferlin inhibitor 1	Inhibitor	99.88%	Unkown
HY-P3484	Dnp-PLGLWA-DArg-NH2 TFA		99.78%	Unkown
HY-114785	BPHA	Inhibitor	99.88%	Unkown
HY-N3387	Licoricidin		98.00%	Unkown
HY-NP109	Highly purified type I collagen, from mouse skin		99%	Unkown
HY-164826	Acetyl zingerone		99.34%	Unkown
HY-171804	Linvemastat	Inhibitor	98.30%	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	99.04%	Unkown
HY-177590	14-3-3-IN-2	Inhibitor	98.41%	Unkown
HY-W745164	3,3′-Bisdemethylpinoresinol	Inhibitor	98.96%	Unkown
HY-122106	RS-104966	Inhibitor	98.39%	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	98.0%	Unkown
HY-NP103	Highly purified Type III collagen, from bovine skin		90.0%	Unkown
HY-NP126	Highly purified Type XI collagen, from porcine articular cartilage		90%	Unkown
HY-P10775A	BT1769 acetate	Inhibitor	/	Unkown
HY-N1190	DL-Syringaresinol	Inhibitor	96%	Unkown
HY-183626	PAI-1-IN-1		99.45%	Unkown
HY-100211A	(R)-TAPI-2	Control	/	Unkown
HY-110046	CL-82198 hydrochloride	Inhibitor	/	Unkown
HY-113621B	Ageladine A dihydrochloride	Inhibitor	/	Unkown
HY-114900	BB-3497		/	Unkown
HY-115373	RO314724	Inhibitor	/	Unkown
HY-119138	R-130823	Inhibitor	/	Unkown
HY-121096	Funalenone	Inhibitor	/	Unkown
HY-125507	F81-1144b	Inhibitor	/	Unkown
HY-126956	Porphyra 334		/	Unkown
HY-15668	ST09		/	Unkown
HY-162131	Antitumor agent-132		/	Unkown
HY-162453	Anticancer agent 204		/	Unkown
HY-175276	JNK-IN-24	Inhibitor	/	Unkown
HY-181769	Anticancer agent 306		/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-18694A	CGS 27023A free base	Inhibitor	/	Unkown
HY-N12653	Exserohilone	Inhibitor	/	Unkown
HY-N1326	Santamarine		98.85%	Unkown
HY-N1981S2	Triolein-13C3-1		/	Unkown
HY-NP104	Highly purified Type V collagen, from bovine amnion		/	Unkown
HY-NP105	Highly purified Type IX collagen, from bovine articular cartilage		/	Unkown
HY-NP106	Highly purified Type XI collagen, from bovine articular cartilage		/	Unkown
HY-NP107	Highly purified Type I collagen, from rat skin		/	Unkown
HY-NP108	Highly purified type II collagen, from rat sternal cartilage		/	Unkown
HY-NP110	Highly purified Type II collagen, from mouse sternal cartilage		/	Unkown
HY-NP111	Highly purified Type V collagen, from mouse intestine		/	Unkown
HY-NP112	Highly purified Type I collagen, from chick skin		/	Unkown
HY-NP114	Highly purified Type IX collagen, from chick articular cartilage		/	Unkown
HY-NP115	Highly purified Type XI collagen, from chick articular cartilage		/	Unkown
HY-NP122	Highly purified Type I collagen, from porcine skin		/	Unkown
HY-NP123	Highly purified Type II collagen, from porcine articular cartilage		/	Unkown
HY-NP124	Highly purified Type III collagen, from porcine skin		/	Unkown
HY-NP125	Highly purified Type IX collagen, from porcine articular cartilage		/	Unkown
HY-NP127	Highly purified Type I collagen, from canine skin		/	Unkown
HY-NP128	Highly purified Type I collagen, from rabbit skin		/	Unkown
HY-NP129	Highly purified Type II collagen, from sheep articular cartilage		/	Unkown
HY-NP130	Highly purified Type II collagen, from goat articular cartilage		/	Unkown
HY-P10043	MMP-1 Substrate	Substrate	/	Unkown
HY-P10775	BT1769	Antagonist	/	Unkown
HY-P2608	DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH		/	Unkown
HY-P3098	Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2		/	Unkown
HY-P3699	TNO003	Substrate	/	Unkown
HY-P4123	TAT (47-57) GGG-Cys(Npys)	Inhibitor	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-RS08516	MMP1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08517	Mmp1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08526	Mmp13 Mouse Pre-designed siRNA Set A		/	Unkown
HY-W095774	(E)-N-(3-Methoxyphenyl)cinnamamide	Inhibitor	/	Unkown
HY-W782935	MAPKAPK5-IN-1		/	Unkown
HY-113440R	5-Methoxytryptophol (Standard)		/	Unkown
HY-123130	ABT-770	Inhibitor	/	Unkown
HY-152092A	(R,R)-MMP-1-IN-1		98.00%	Unkown
HY-N0363AR	(+)-Columbianetin acetate (Standard)		/	Unkown
HY-N0363R	(+)-Columbianetin (Standard)		/	Unkown
HY-N11072	Tremulacin	Inhibitor	96.41%	Unkown
HY-N1151	Thunberginol C	Inhibitor	/	Unkown
HY-N12150	Isozedoarondiol	Inhibitor	/	Unkown
HY-P3699A	TNO003 TFA	Substrate	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MMP1	RGD	RGD:1307917
Canis familiaris	MMP1	VGNC	VGNC:43273
Felis catus	MMP1	VGNC	VGNC:82017
Macaca mulatta	MMP1	VGNC	VGNC:74887
Others	MMP1	NCBI