2. Gene
  3. App - amyloid beta precursor protein Gene

App - amyloid beta precursor protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Abeta

Gene ID: 54226 | Gene type: protein coding

About App

Primary_assembly 11: 24,019,778-24,236,561 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Kidney (RPKM 196.2), Lung (RPKM 1647.7) and 9 other tissues.

Summary

Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App Products(1)

mRNA Protein Name
NM_019288.2 NP_062161.1 amyloid-beta precursor protein precursor

App Protein Structure

A4_EXTRA

A4_EXTRA: smart00006 (23 - 187)

Kunitz_ABPP-like

Kunitz_ABPP-like: cd22607 (293 - 340)

APP_E2

APP_E2: pfam12925 (365 - 547)

JMTM_Notch_APP

JMTM_Notch_APP: cl41775 (692 - 766)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

amyloid-beta precursor protein

amyloid-beta A4 protein

ABPP

AG

alzheimer disease amyloid A4 protein homolog

alzheimer disease amyloid protein

amyloid A4

amyloid beta (A4) precursor protein

amyloid beta A4 protein

amyloid precursor protein

amyloidogenic glycoprotein

beta-amyloid precursor protein

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14537 Latrepirdine dihydrochloride 99.71% Yes
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-16009 Buntanetap Inhibitor 98.11% Phase 3
HY-10254 Mirdametinib 99.95% Phase 2
HY-50759 Ispinesib 99.62% Phase 2
HY-N0192 Arbutin Inhibitor ≥98.0% Phase 2
HY-106005 MMV390048 Inhibitor 99.17% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99185 Bapineuzumab 96.62% Phase 3
HY-P990078 Remternetug Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (63)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103490 Takinib 99.31% Unkown
HY-139214 IXA4 Inhibitor 99.16% Unkown
HY-19369 L-685458 99.37% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-135699 TD52 ≥95.0% Unkown
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.62% Unkown
HY-108643 CMPD1 Inhibitor 99.86% Unkown
HY-123960A Raphin1 acetate Inhibitor 99.88% Unkown
HY-124832 δ-Secretase inhibitor 11 Inhibitor 99.06% Unkown
HY-129096 IDT307 99.76% Unkown
HY-124322 NB-360 Inhibitor 99.22% Unkown
HY-15294 CZC24832 Inhibitor 99.35% Unkown
HY-18010 PCI 29732 Inhibitor 99.86% Unkown
HY-103374 Phenserine Inhibitor 99.55% Unkown
HY-18292 ARN2966 Inhibitor 99.87% Unkown
HY-50883 BMS 299897 Inhibitor 99.24% Unkown
HY-12989 LDN-91946 Inhibitor 98.70% Unkown
HY-136499 DI-82 98.76% Unkown
HY-126242S Tyk2-IN-7 Inhibitor 99.62% Unkown
HY-120597 SAK3 Activator ≥99.0% Unkown
HY-50882 ELN318463 Inhibitor 99.45% Unkown
HY-153986 AEP-IN-2 / Unkown
HY-19918A Anatabine dicitrate 99.03% Unkown
HY-135699A TD52 dihydrochloride 99.90% Unkown
HY-139973 OAB-14 98.72% Unkown
HY-161110 Aβ42-IN-5 Degrader 98.35% Unkown
HY-117924 AUTEN-67 Inducer / Unkown
HY-131068 BACE-1 inhibitor 2 Inhibitor / Unkown
HY-128585 GNE684 Inhibitor / Unkown
HY-P2551 Biotin-β-Amyloid (17-40) / Unkown
HY-103538 JLK-6 Inhibitor / Unkown
HY-105940 IQB-782 / Unkown
HY-107164 Thiomarinol A Inhibitor / Unkown
HY-108966 Kushenol C Inhibitor / Unkown
HY-123960 Raphin1 Inhibitor / Unkown
HY-126047B (R)-(+)-Anatabine / Unkown
HY-128464 LL320 / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-136733 Ac-DNLD-CHO Inhibitor / Unkown
HY-144739 BACE1-IN-8 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-145286 IMPDH2-IN-2 / Unkown
HY-147672 IleRS-IN-1 Inhibitor / Unkown
HY-147674 Isoleucyl tRNA synthetase-IN-2 Inhibitor / Unkown
HY-149396 FXIIa-IN-1 / Unkown
HY-161109 Aβ42-IN-4 / Unkown
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / Unkown
HY-P10163 α-Secretase Substrate II, Fluorogenic / Unkown
HY-P10180 β-Amyloid/A4 Protein Precusor (319-335) / Unkown
HY-P1378 β-Amyloid (1-43)(human) / Unkown
HY-P1378A β-Amyloid (1-43)(human) TFA / Unkown
HY-P1729 M-2420 / Unkown
HY-P1894 β-Amyloid Protein Precursor 770 (135-155) / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P4553 H-Met-Pro-OH / Unkown
HY-P4919 Mca-SEVNLDAEFK(Dnp) / Unkown
HY-RS00863 APP Human Pre-designed siRNA Set A / Unkown
HY-RS00864 App Mouse Pre-designed siRNA Set A / Unkown
HY-RS00865 App Rat Pre-designed siRNA Set A / Unkown
HY-149397 FXIIa-IN-2 / Unkown
HY-16009B Buntanetap L-Tartrate / Unkown
HY-50882A ELN318463 racemate Inhibitor / Unkown
HY-P4885 Glp-amyloid-β (3-40) peptide (human) / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9999 Trontinemab Inhibitor 96.77% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens App NCBI NCBI:351