App - amyloid beta precursor protein Gene

Also Known as Abeta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54226

About App

Primary_assembly 11: 24,019,778-24,236,561 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Kidney (RPKM 196.2), Lung (RPKM 1647.7) and 9 other tissues.

Summary

Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to Other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App Products (1)

mRNA Protein Name
NM_019288.2 NP_062161.1 amyloid-beta precursor protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor receptor binding IPI
IPI: Inferred from physical interaction
19334058 RGD
enables peptidase activator activity IDA
IDA: Inferred from direct assay
12493564 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9461550 RGD
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
20209079 RGD
involved in antifungal humoral response IDA
IDA: Inferred from direct assay
20209079 RGD
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
20209079 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9144253 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
18583042 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
18583042 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
10821917 RGD
involved in cellular response to norepinephrine stimulus IMP
IMP: Inferred from mutant phenotype
9144253 RGD
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
20209079 RGD
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
20209079 RGD
involved in innate immune response IDA
IDA: Inferred from direct assay
20209079 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11404397 RGD
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
11404397 RGD
involved in positive regulation of protein metabolic process IDA
IDA: Inferred from direct assay
11404397 RGD
involved in regulation of response to calcium ion IGI
IGI: Inferred from genetic interaction
11404397 RGD
involved in response to interleukin-1 IDA
IDA: Inferred from direct assay
20395292 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
16230335 RGD
involved in response to yeast IDA
IDA: Inferred from direct assay
20209079 RGD
Cellular Component GO Annotation Evidence References Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
8097074 RGD
located in axon IDA
IDA: Inferred from direct assay
8987743 RGD
located in cell surface IDA
IDA: Inferred from direct assay
8987743 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
14615045 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12843239 RGD
located in growth cone filopodium IDA
IDA: Inferred from direct assay
12843239 RGD
located in growth cone lamellipodium IDA
IDA: Inferred from direct assay
12843239 RGD
located in main axon IDA
IDA: Inferred from direct assay
12843239 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
29577889 RGD
NOT located in synaptic vesicle IDA
IDA: Inferred from direct assay
8987743 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

App Protein Structure

A4_EXTRA

A4_EXTRA: smart00006 (23 - 187)

Kunitz_ABPP-like

Kunitz_ABPP-like: cd22607 (293 - 340)

APP_E2

APP_E2: pfam12925 (365 - 547)

JMTM_Notch_APP

JMTM_Notch_APP: cl41775 (692 - 766)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

amyloid-beta precursor protein

amyloid-beta A4 protein

  • ABPP

  • AG

  • alzheimer disease amyloid A4 protein homolog

  • alzheimer disease amyloid protein

  • amyloid A4

  • amyloid beta (A4) precursor protein

  • amyloid beta A4 protein

  • amyloid precursor protein

  • amyloidogenic glycoprotein

  • beta-amyloid precursor protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0192 Arbutin Inhibitor 99.76% Unkown
HY-14537 Latrepirdine dihydrochloride 99.65% Yes
HY-14862 Latrepirdine 99.51% Yes

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-103374 Phenserine Inhibitor 99.55% Phase 3
HY-10254 Mirdametinib 99.95% Phase 2
HY-50759 Ispinesib 99.62% Phase 2
HY-106005 MMV390048 Inhibitor 98.85% Phase 2
HY-177646 Mivelsiran Inhibitor 95.96% Phase 2
HY-177646A Mivelsiran sodium Inhibitor 95.46% Phase 2
HY-19846 VRX-03011 Agonist / Phase 2
HY-13438 AZD3839 free base Inhibitor 99.97% Phase 1
HY-103374A Phenserine tartrate Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99185 Bapineuzumab 96.62% Phase 3

Pre-clinical Phase

Bioactive Molecules (112)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103490 Takinib 99.48% Unkown
HY-139214 IXA4 Inhibitor 98.92% Unkown
HY-19369 L-685458 99.69% Unkown
HY-P5381 gp91 ds-tat 99.00% Unkown
HY-16009 Buntanetap 99.71% Unkown
HY-123960 Raphin1 Inhibitor 99.74% Unkown
HY-N1472 Levistolide A 99.34% Unkown
HY-129096 IDT307 99.74% Unkown
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.55% Unkown
HY-129430 N-Methylprotoporphyrin IX Inhibitor 99.0% Unkown
HY-P6365B APP-018 99.80% Unkown
HY-124832 δ-Secretase inhibitor 11 Inhibitor 99.89% Unkown
HY-120597 SAK3 Activator 99.80% Unkown
HY-13769A TPT-260 Dihydrochloride 98.0% Unkown
HY-135699 TD52 95.0% Unkown
HY-108643 CMPD1 Inhibitor 99.81% Unkown
HY-12989 LDN-91946 Inhibitor 98.04% Unkown
HY-109536B Ammonium polyphosphate, n<20, water solubility>90 g/100 mL / Unkown
HY-50883 BMS 299897 Inhibitor 99.64% Unkown
HY-15294 CZC24832 Inhibitor 99.07% Unkown
HY-18292 ARN2966 Inhibitor 98.78% Unkown
HY-W747599 Ganglioside GQ1b (bovine) sodium ≥98.0% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-123960A Raphin1 acetate Inhibitor 99.93% Unkown
HY-161110 APP degrader-1 Degrader 99.11% Unkown
HY-117924 AUTEN-67 Inducer 97.14% Unkown
HY-161723 LH2-051 Inhibitor 99.85% Unkown
HY-126242S Tyk2-IN-7 Inhibitor 99.58% Unkown
HY-171347 gamma-secretase modulator 6 99.68% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-152846 Flizasertib Inhibitor 99.9% Unkown
HY-128090A Apstatin TFA Inhibitor 99.57% Unkown
HY-145286 IMPDH2-IN-2 99.89% Unkown
HY-153986 AEP-IN-2 Inhibitor 99.13% Unkown
HY-176036 MS1262 Inhibitor 98.61% Unkown
HY-N3001 Isolinderalactone 98.79% Unkown
HY-135699A TD52 dihydrochloride 99.55% Unkown
HY-139973 OAB-14 99.21% Unkown
HY-50882 ELN318463 Inhibitor 99.45% Unkown
HY-N1414A 3′,6-Disinapoylsucrose Inhibitor 98.88% Unkown
HY-128585 GNE684 Inhibitor 99.08% Unkown
HY-108966 Kushenol C Inhibitor 99.58% Unkown
HY-128464 LL320 Inhibitor 99.91% Unkown
HY-P1378A β-Amyloid (1-43)(human) TFA 95.42% Unkown
HY-RS00863 APP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-19918A Anatabine dicitrate 99.03% Unkown
HY-16009B Buntanetap L-Tartrate 98.93% Unkown
HY-174367 RUNX1/ETO-IN-1 91.18% Unkown
HY-P1894A β-Amyloid Protein Precursor 770 (135-155) TFA / Unkown
HY-P4553A H-Met-Pro-OH acetate 98.41% Unkown
HY-131068 BACE-1 inhibitor 2 Inhibitor / Unkown
HY-P2551 Biotin-β-Amyloid (17-40) / Unkown
HY-103374B (±)Phenserine Inhibitor / Unkown
HY-105940 IQB-782 / Unkown
HY-107164 Thiomarinol A Inhibitor / Unkown
HY-108041 MGS 0210 Agonist / Unkown
HY-118243 KMS88009 Inhibitor / Unkown
HY-118245 APP-FUBINACA Agonist / Unkown
HY-118972 TPI-1917-49 Inhibitor / Unkown
HY-125405 AZ3971 Inhibitor / Unkown
HY-125472 LC-1028 Inhibitor / Unkown
HY-126047B (R)-(+)-Anatabine / Unkown
HY-13438A AZD3839 fumarate Inhibitor / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-136733 Ac-DNLD-CHO Inhibitor / Unkown
HY-139052 III-31-C Inhibitor / Unkown
HY-144739 BACE1-IN-8 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-147672 IleRS-IN-1 Inhibitor / Unkown
HY-147674 Isoleucyl tRNA synthetase-IN-2 Inhibitor / Unkown
HY-147927A (S)-Human enteropeptidase-IN-1 Inhibitor / Unkown
HY-149396 FXIIa-IN-1 Inhibitor / Unkown
HY-149396A FXIIa-IN-1 hydrochloride Inhibitor / Unkown
HY-161109 Aβ42-IN-4 / Unkown
HY-161953 O-GlcNAcase-IN-2 Inhibitor / Unkown
HY-168241 Flucopride / Unkown
HY-168859 JNK3 inhibitor-9 Inhibitor / Unkown
HY-169296 IMPDH2-IN-4 Inhibitor / Unkown
HY-176271 MAO-B-IN-45 / Unkown
HY-176749 HUP-46 / Unkown
HY-180997 Aβ aggregation-IN-5 Inhibitor / Unkown
HY-182050 YL0441 Inhibitor / Unkown
HY-182367 TMN-OMe Agonist / Unkown
HY-182429 NB-533 Inhibitor / Unkown
HY-183057 GRK2 modulator 1 / Unkown
HY-401209 Synucleozid-2.0 Inhibitor 98.01% Unkown
HY-50759A Ispinesib mesylate / Unkown
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / Unkown
HY-N13064 2,2′,4,4′-Tetrahydroxychalcone Inhibitor / Unkown
HY-P10163 α-Secretase Substrate II, Fluorogenic / Unkown
HY-P10180 β-Amyloid/A4 Protein Precusor (319-335) / Unkown
HY-P10247 Amyloid precursor C-terminal peptide / Unkown
HY-P10487 APP669-711 / Unkown
HY-P1378 β-Amyloid (1-43)(human) / Unkown
HY-P1729 M-2420 / Unkown
HY-P1894 β-Amyloid Protein Precursor 770 (135-155) / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P4553 H-Met-Pro-OH / Unkown
HY-P4919 Mca-SEVNLDAEFK(Dnp) / Unkown
HY-P4926 Mca-SEVKMDAEFRK(Dnp)RR-NH2 / Unkown
HY-P5274 BACE1 (485-501) / Unkown
HY-RS00864 App Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00865 App Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121817 Sulfiram Inhibitor 96.35% Unkown
HY-128090 Apstatin Inhibitor / Unkown
HY-129133 cis-Miyabenol C / Unkown
HY-133184 Aminogenistein Inhibitor / Unkown
HY-13769 TPT-260 / Unkown
HY-149397 FXIIa-IN-2 Inhibitor / Unkown
HY-180856 APP modulator-1 / Unkown
HY-50882A ELN318463 racemate Inhibitor / Unkown
HY-P4885 Glp-amyloid-β (3-40) peptide (human) / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990301 Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) Inhibitor 95% Unkown
HY-P991130 Dalidnetug Ligand 96.686% Unkown
HY-P992157 Anti-APP/Amyloid beta Antibody (3D6) Ligand / Unkown
HY-P992356 GENA-104A16 Inhibitor / Unkown
HY-P992411 MEDI-8490 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens App NCBI NCBI:351