Tyk2 - tyrosine kinase 2 Gene

Also Known as JTK1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54721

About Tyk2

Chromosome 9: 21,015,364-21,042,539 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 43 phenotypes. Ubiquitous expression in spleen adult (RPKM 21.7), mammary gland adult (RPKM 15.9) and 28 other tissues.

Summary

Predicted to enable growth hormone receptor binding activity; protein tyrosine kinase activity; and type 1 Angiotensin Receptor binding activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and nucleus. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human Tyk2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tyk2 Products (2)

mRNA Protein Name
NM_001205312.1 NP_001192241.1 non-receptor tyrosine-protein kinase TYK2 isoform 1
NM_018793.2 NP_061263.2 non-receptor tyrosine-protein kinase TYK2 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cell population proliferation IGI
IGI: Inferred from genetic interaction
15781341 MGI
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11114383 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tyk2 Protein Structure

FERM_F1

FERM_F1: pfam18379 (32 - 127)

FERM_F2

FERM_F2: pfam18377 (145 - 268)

Jak1_Phl

Jak1_Phl: pfam17887 (287 - 430)

SH2

SH2: cl15255 (435 - 533)

PKc_like

PKc_like: cl21453 (588 - 863)

PTKc_Tyk2_rpt2

PTKc_Tyk2_rpt2: cd05080 (888 - 1170)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1184 a.a.
Protein Preferred Names Protein Names

non-receptor tyrosine-protein kinase TYK2

  • tyrosine kinase TYK2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-50858 Ruxolitinib phosphate Inhibitor 99.92% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Phase
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 4
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-174905 Quecitinib Inhibitor 99.56% Phase 3
HY-13034 Gandotinib Inhibitor 99.86% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-160144S Lomedeucitinib Inhibitor 99.75% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-159536 Frevecitinib Inhibitor 99.42% Phase 2
HY-131968 BMS-986202 Inhibitor 99.29% Phase 1
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (63)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-19631A Ilginatinib Inhibitor 99.81% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-113787 (R)-9b Inhibitor 99.51% Unkown
HY-158142 PROTAC TYK2 degrader-1 Degrader 99.55% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-16640 TCJL37 Inhibitor 99.89% Unkown
HY-126242S Tyk2-IN-7 Inhibitor 99.58% Unkown
HY-101762 TyK2-IN-2 Inhibitor 99.05% Unkown
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Yes
HY-111745 Tyk2-IN-5 Inhibitor 99.35% Unkown
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-143884 JAK2/TYK2-IN-1 Inhibitor 99.94% Unkown
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-18710 BMS-066 Inhibitor 99.09% Unkown
HY-18315 Bayer-18 Inhibitor / Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-184075S Nomelcitinib Inhibitor / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-175983 JAK1/TYK2-IN-5 Inhibitor / Unkown
HY-163304 Tyk2-IN-16 Inhibitor / Unkown
HY-177131 Soficitinib Inhibitor 98.54% Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-18709 Tyk2-IN-3 Inhibitor / Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-177130S Socrodeucitinib Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-175310S Voderdeucitinib Inhibitor / Unkown
HY-181278 Deucravacitinib analog 1 / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-401428 TYK2 ligand 3 Degrader / Unkown
HY-176793 JAK1-IN-18 Inhibitor / Unkown
HY-173359 TYK2 ligand 2 Ligand / Unkown
HY-158692 Tyk2-IN-18 Inhibitor / Unkown
HY-112783 TYK2 ligand 4 Ligand / Unkown
HY-168339 Tyk2-IN-22 Inhibitor / Unkown
HY-158340 TYK2 ligand 1 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-184833 Tyk2-IN-25 Inhibitor / Unkown
HY-184786 Tyk2-IN-14 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-184866 Tyk2-IN-26 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyk2 NCBI NCBI:7297