1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. HSP90-IN-11

HSP90-IN-11 

Cat. No.: HY-146325
Handling Instructions

HSP90-IN-11 (Compound 12c) is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population.

For research use only. We do not sell to patients.

HSP90-IN-11 Chemical Structure

HSP90-IN-11 Chemical Structure

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Description

HSP90-IN-11 (Compound 12c) is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population[1].

Molecular Weight

511.54

Formula

C27H30FN3O6

SMILES

CCN(C1=CC=C(C=C1)CN2C(C(F)=CN(C2=O)C3CCCO3)=O)C(C4=CC(C(C)C)=C(C=C4O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HSP90-IN-11
Cat. No.:
HY-146325
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