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HSP90-IN-11

HSP90-IN-11 (Compound 12c) is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population.

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  • CAS No.: 2986564-20-7
  • Formula: C27H30FN3O6
  • Molecular Weight:511.54
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • HSP90-IN-11 Chemical Structure
    HSP90-IN-11 Chemical Structure
CAS No.: 2986564-20-7
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    HSP90-IN-11 Chemical Structure
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  • HSP90-IN-11