製品番号: HY-N6843

Arnicolide D

(別名: アルニコリドD)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.69%
CAS 番号: 34532-68-8
分子式: C₁₉H₂₄O₅
分子量:332.39

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Arnicolide D 構造式

CAS 番号: 34532-68-8

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価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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製品説明

Caspase アイソフォーム固有の製品をすべて表示 :

PI3K アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

mTOR アイソフォーム固有の製品をすべて表示 :

STAT アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

体外実験

Arnicolide D (0-50 μM; 24-72 h) exhibits significant cytotoxicity against nasopharyngeal carcinoma cells, capable of inducing cell cycle arrest at the G2/M phase and apoptosis. The mechanism involves the activation of the caspase signaling pathway and the inhibition of the PI3K/AKT/mTOR and STAT3 signaling pathways^[1].
Arnicolide D (0-20 μM; 8-24 h) induces endoplasmic reticulum stress-mediated and ROS-dependent oncosis in hepatocellular carcinoma cells via ATF4 and CHOP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CNE-2 cells
Concentration:

0, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
Incubation Time:

24, 48 and 72 h
Result:

Inhibited cell growth in a concentration- and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

CNE-2 cells
Concentration:

0, 1.25, 2.5, 5, 10 and 20 μM
Incubation Time:

24 and 48 h
Result:

Downregulate cyclin D3, cdc2, p-PI3K, p-AKT, p-mTOR, and p-STAT3.
Upregulated cleaved PARP, cleaved caspase 9, and Bax.

体内実験

Arnicolide D (4-8 mg/kg; intraperitoneal injection; 15 days) has anti-melanoma effects in the B16F10 allograft mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male 6-week old C57/BL6 mice treated B16F10^[3]
Dosage:

4 and 8 mg/kg
Administration:

Intraperitoneal injection (i.p.); 15 days
Result:

Reduced the average tumor weight by 53.7% compared with the vehicle-treated group at a dose of 4 mg/kg.
Did not cause death, toxic symptoms in mice, and no abnormalities were found during autopsy.
Was more effective at 4 mg/kg than at 8 mg/kg in suppressing tumor growth.

化学情報

CAS 番号 34532-68-8
性状 Solid
分子量 332.39
分子式 C₁₉H₂₄O₅
Color White to off-white
SMILES

CC(C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O)=C
別名

アルニコリドD
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Phytomedicine

Huaier-derived arnicolide D induces ferroptosis in gastric cancer via SRC/TNF-mediated GPX4 inactivation. [Abstract]

2026 May:154:158029. PMID: 41818944
J Ethnopharmacol

Screening tumor specificity targeted by arnicolide D, the active compound of Centipeda minima and molecular mechanism underlying by integrative pharmacology. [Abstract]

2022 Jan 10:282:114583. PMID: 34487850

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (300.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0085 mL

15.0426 mL

30.0851 mL

5 mM

0.6017 mL

3.0085 mL

6.0170 mL

10 mM

0.3009 mL

1.5043 mL

3.0085 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10). [Content Brief]

[2]. Lin YS, et al. Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. Cell Death Discov. 2024 Mar 12;10(1):134. [Content Brief]

[3]. Zhu P, et al. Arnicolide D exerts anti-melanoma effects and inhibits the NF-κB pathway. Phytomedicine. 2019 Nov;64:153065. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0085 mL	15.0426 mL	30.0851 mL	75.2128 mL
	5 mM	0.6017 mL	3.0085 mL	6.0170 mL	15.0426 mL
	10 mM	0.3009 mL	1.5043 mL	3.0085 mL	7.5213 mL
	15 mM	0.2006 mL	1.0028 mL	2.0057 mL	5.0142 mL
	20 mM	0.1504 mL	0.7521 mL	1.5043 mL	3.7606 mL
	25 mM	0.1203 mL	0.6017 mL	1.2034 mL	3.0085 mL
	30 mM	0.1003 mL	0.5014 mL	1.0028 mL	2.5071 mL
	40 mM	0.0752 mL	0.3761 mL	0.7521 mL	1.8803 mL
	50 mM	0.0602 mL	0.3009 mL	0.6017 mL	1.5043 mL
	60 mM	0.0501 mL	0.2507 mL	0.5014 mL	1.2535 mL
	80 mM	0.0376 mL	0.1880 mL	0.3761 mL	0.9402 mL
	100 mM	0.0301 mL	0.1504 mL	0.3009 mL	0.7521 mL

Keywords

Arnicolide D

2 Cited Publications

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Arnicolide D

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MedChemExpress（MCE）の使用を引用している文献 Arnicolide D

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Akt アイソフォーム固有の製品をすべて表示

mTOR アイソフォーム固有の製品をすべて表示

STAT アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

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