製品番号: HY-134000

Emodic acid

(別名: NSC624610)

カスタマーレビュー

Based on 1 Customer Validation

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.

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純度: 98.00%
CAS 番号: 478-45-5
分子式: C₁₅H₈O₇
分子量:300.22

保管条件:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Emodic acid 構造式

CAS 番号: 478-45-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

p38 MAPK アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

JNK アイソフォーム固有の製品をすべて表示 :

VEGFR アイソフォーム固有の製品をすべて表示 :

MMP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]
Jurkat	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]
K562	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 28509552]

体外実験

Emodic acid(0-100 μM, 72 h) exhibits strong antiproliferative activity with the IC₅₀ values of 9.33, 8.56, 7.95 μM in murine mammary carcinoma 4T1, MDA-231 and MCF-7 cell lines, respectively^[1].
Emodic acid (50 μM, 24 h) can significantly inhibit NF-κB transcriptional activity by 80.75%, inhibit p65 phosphorylation and the mRNA expression of MMP-9 in 4T1 cell line^[1].
Emodic acid(50 μM, 24 h) can inhibit the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of VEGF, thereby inhibiting the invasion and migration of 4T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 478-45-5
性状 Solid
分子量 300.22
分子式 C₁₅H₈O₇
Color Brown to red
SMILES

OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O
別名

NSC624610
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 4 mg/mL (13.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3309 mL

16.6545 mL

33.3089 mL

5 mM

0.6662 mL

3.3309 mL

6.6618 mL

10 mM

0.3331 mL

1.6654 mL

3.3309 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3309 mL	16.6545 mL	33.3089 mL	83.2723 mL
	5 mM	0.6662 mL	3.3309 mL	6.6618 mL	16.6545 mL
	10 mM	0.3331 mL	1.6654 mL	3.3309 mL	8.3272 mL

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Emodic acid

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p38 MAPK アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示

VEGFR アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Emodic acid 関連分類

HY-134000 関連分類