Pomalidomide-d5
Pomalidomide-d5 is deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1377838-49-7
- 分子式: C13H6D5N3O4
- 分子量:278.27
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-125305
Z-AEVD-FMKCaspase-10 Inhibitor -
HY-124923
LupuloneBacterial Inhibitor -
HY-16569S
Colchicine-d6Stable Isotope -
HY-B0261S
Meloxicam-d3Stable Isotope -
HY-13757AS
Tamoxifen-d5Stable Isotope -
HY-B0351S
Taurine-d4Stable Isotope -
HY-124923R
Lupulone (Standard)Bacterial Inhibitor -
HY-17504BS1
Rosuvastatin-d6 sodiumStable Isotope -
HY-P2377
Ac-YVAD-AFCCaspase-1/4 Fluorometric Peptide Substrate -
HY-P0034
Ac-DEVD-CMKCaspase-3 Inhibitor -
HY-B0335S
Tolfenamic acid-d4Stable Isotope -
HY-B0279S
Ramipril-d5Stable Isotope
生物活性
製品説明
IC50 & Target
|
Cereblon |
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
-
CAS 番号 1377838-49-7
-
非標識Cas 19171-19-8
-
分子量 278.27
-
分子式 C13H6D5N3O4
-
SMILES
NC1=C2C(C(N(C2=O)C3(C(NC(C([2H])(C3([2H])[2H])[2H])=O)=O)[2H])=O)=CC=C1
-
別名
CC-4047-d5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7. [Content Brief]
[3]. Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11(16):5984-92. [Content Brief]
[4]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther. 2003 Jun;305(3):1222-32. [Content Brief]
[5]. Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PLoS One. 2013 Aug 5;8(8):e71754. [Content Brief]
[6]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63. [Content Brief]
[7]. Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.). Gen Comp Endocrinol. 2016 Mar 1;228:1-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pomalidomide-d5 関連分類
HY-10984S 関連分類
Powered by Bioz