Dpp4 - dipeptidylpeptidase 4 Gene

Also Known as Cd26; THAM; Dpp-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13482

About Dpp4

Chromosome 2: 62,160,417-62,242,575 reverse strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 31 phenotypes. Biased expression in large intestine adult (RPKM 3.2), small intestine adult (RPKM 11.7) and 11 other tissues.

Summary

Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 Products (2)

mRNA Protein Name
NM_001159543.1 NP_001153015.1 dipeptidyl peptidase 4 isoform 2
NM_010074.3 NP_034204.1 dipeptidyl peptidase 4 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
16712972 MGI
acts upstream of or within locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
16712972 MGI
acts upstream of or within psychomotor behavior IMP
IMP: Inferred from mutant phenotype
16712972 MGI
Cellular Component GO Annotation Evidence References Source
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
12068294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dpp4 Protein Structure

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (101 - 471)

Peptidase_S9

Peptidase_S9: pfam00326 (552 - 756)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 4

  • DPP IV

  • T-cell activation antigen CD26

  • dipeptidyl peptidase IV

  • thymocyte-activating molecule

Recombinant Dpp4 Proteins

Cat. No. Product Name Accession Purity
HY-P75429 CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, Fc) P28843 (S29-H760) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13749 Sitagliptin Inhibitor 99.94% Yes
HY-10284 Linagliptin 99.74% Unkown
HY-13749A Sitagliptin phosphate Inhibitor 99.88% Yes
HY-10285 Saxagliptin Inhibitor 99.96% Yes
HY-A0023A Alogliptin Inhibitor 99.93% Unkown
HY-14806B Teneligliptin hydrobromide hydrate 99.97% Unkown
HY-14806 Teneligliptin Inhibitor 99.79% Unkown
HY-14806A Teneligliptin hydrobromide 99.99% Unkown
HY-15408 Trelagliptin Inhibitor 99.81% Unkown
HY-15981 Omarigliptin Inhibitor 99.96% Unkown
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.83% Yes
HY-14877 Anagliptin Inhibitor 99.92% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.98% Unkown
HY-15408A Trelagliptin succinate Inhibitor 99.87% Unkown
HY-108795 Albiglutide fragment Agonist 99.86% Unkown
HY-16448 Saxagliptin hydrochloride Inhibitor 99.54% Yes
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% Yes
HY-14892 Gemigliptin Inhibitor / Unkown
HY-13749AR Sitagliptin phosphate (Standard) Inhibitor 99.82% Unkown
HY-108795A Albiglutide fragment TFA Agonist 99.12% Unkown
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
HY-13749E Sitagliptin hydrochloride Inhibitor / Unkown
HY-13749R Sitagliptin (Standard) Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5311 Albiglutide Agonist 99.92% Unkown
HY-P9805 Anti-MERS-3A1 mAb Inhibitor ≥99.0% Unkown
HY-P9806 Anti-MERS-D12 mAb Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-117985B Evogliptin tartrate 98.11% Phase 4
HY-14806S Teneligliptin-d8 Inhibitor / Phase 4
HY-117985 Evogliptin / Phase 4
HY-112668 Retagliptin phosphate Inhibitor 99.71% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.29% Phase 3
HY-10286 Dutogliptin Inhibitor 99.21% Phase 3
HY-10286A Dutogliptin tartrate Inhibitor / Phase 3
HY-112668B Retagliptin hydrochloride Inhibitor / Phase 3
HY-125330 Denagliptin tosylate Inhibitor / Phase 3
HY-167680 Denagliptin / Phase 3
HY-10288 Melogliptin Inhibitor / Phase 2
HY-139792 Besigliptin tosylate / Phase 2
HY-12528 DBPR108 Inhibitor 99.93% Phase 1
HY-122188 TAK-100 Inhibitor / Phase 1
HY-16656 BMS-767778 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991551 YS110 99.75% Phase 2
HY-P991445 REGN3051 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1141 GLP-1(9-36)amide Antagonist 99.69% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 99.52% Unkown
HY-112668A Retagliptin Inhibitor 98.51% Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.61% Unkown
HY-N6079 Timosaponin A1 Inhibitor 99.70% Unkown
HY-P4344 Met-Gly-Pro-AMC Substrate 99.74% Unkown
HY-10284S Linagliptin-d4 99.9% Unkown
HY-14892B Gemigliptin tartrate hydrate Inhibitor 99.83% Unkown
HY-W003222 N-tert-Boc-cis-4-fluoro-L-proline 99.0% Unkown
HY-171454 DA-1241 Agonist 99.18% Unkown
HY-13749AS Sitagliptin-d4 phosphate Inhibitor 99.48% Unkown
HY-13749S1 Sitagliptin-d4 hydrochloride Inhibitor 99.36% Unkown
HY-158315 NZ-97 Inhibitor 99.43% Unkown
HY-123377A Fotagliptin benzoate Inhibitor 99.19% Unkown
HY-147401 Sitagliptin fenilalanil Inhibitor 99.57% Unkown
HY-131250 N-Boc-Sitagliptin 98.87% Unkown
HY-RS03963 DPP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W003592A L-Orinithine lactam hydrochloride 97.0% Unkown
HY-123377 Fotagliptin Inhibitor 99.05% Unkown
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-A0023AS Alogliptin-13C,d3 Inhibitor / Unkown
HY-I0786 (2S,4R)-Teneligliptin Inhibitor / Unkown
HY-117985A Evogliptin hydrochloride Inhibitor / Unkown
HY-170569 Cetagliptin / Unkown
HY-10284S1 Linagliptin-13C,d3 / Unkown
HY-10284S3 Linagliptin-d3-1 / Unkown
HY-10285S Saxagliptin-15N,d2 hydrochloride Inhibitor / Unkown
HY-10287A Gosogliptin hydrochloride Inhibitor / Unkown
HY-103432 DPP4-In / Unkown
HY-111294 ASP4000 hydrochloride Inhibitor / Unkown
HY-117985BS Evogliptin-d9 tartrate / Unkown
HY-121029 Bisegliptin / Unkown
HY-13749C (S)-Sitagliptin phosphate Inhibitor / Unkown
HY-13749S2 Sitagliptin-d4 Inhibitor / Unkown
HY-146455 DPP-4-IN-3 Inhibitor / Unkown
HY-146468 DPP-4/GPR119 modulator 1 / Unkown
HY-146469 DPP-4/GPR119 modulator 2 / Unkown
HY-14806S1 Teneligliptin-d4 Inhibitor / Unkown
HY-14892C Gemigliptin hydrochloride Inhibitor / Unkown
HY-151383 DPP-4-IN-1 Inhibitor / Unkown
HY-151384 DPP-4-IN-2 Inhibitor / Unkown
HY-153522 ZY15557 Inhibitor / Unkown
HY-15408S Trelagliptin-13C,d3 Inhibitor / Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-155961 Antidiabetic agent 2 Inhibitor / Unkown
HY-157390 DPP-4-IN-9 Inhibitor / Unkown
HY-159491 DPP-4-IN-11 Inhibitor / Unkown
HY-161428 ZINC000003015356 Inhibitor / Unkown
HY-162513 DPP-4-IN-10 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-168621 DPP-4-IN-13 Inhibitor / Unkown
HY-169110 DPP-4-IN-12 Inhibitor / Unkown
HY-170572 PB01 Inhibitor / Unkown
HY-170657 DPP-4-IN-14 Inhibitor / Unkown
HY-176000 Sulphostin Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-179473 MK-0626 / Unkown
HY-182336 DeDPP4 / Unkown
HY-184139 KGDI-109 Inhibitor / Unkown
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / Unkown
HY-P10760 PhAc-ALGP-Dox / Unkown
HY-P11823 FAPα/DPP4 flurogenic substrate-1 / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W741755A 5-Hydroxy saxagliptin hydrochloride Inhibitor / Unkown
HY-W741755S1 5-Hydroxy saxagliptin-13C,d2-2 hydrochloride Inhibitor / Unkown
HY-Z1764 DPP-4-IN-18 Inhibitor / Unkown
HY-10284S4 Linagliptin-d5 / Unkown
HY-10284S5 Linagliptin-d6 / Unkown
HY-10285S2 Saxagliptin-13C2 Inhibitor / Unkown
HY-109060 Garvagliptin Inhibitor / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-117985S Evogliptin-d9 / Unkown
HY-119266 HTS13517 Inhibitor / Unkown
HY-132489S (Rac)-Sitagliptin-d4 Inhibitor / Unkown
HY-132489S1 (Rac)-Sitagliptin-d4-1 hydrochloride Inhibitor / Unkown
HY-13749D (Rac)-Sitagliptin Inhibitor / Unkown
HY-13749S3 Sitagliptin-d6 Inhibitor / Unkown
HY-14806S2 Teneligliptin-d5 Inhibitor / Unkown
HY-14877S1 Anagliptin-d7 Inhibitor / Unkown
HY-170800 DPP-4-IN-15 Inhibitor / Unkown
HY-174832 DPP-4-IN-16 Inhibitor / Unkown
HY-175590 DPP-4-IN-17 Inhibitor / Unkown
HY-180527 SGLT2-IN-5 Inhibitor / Unkown
HY-180528 SGLT2-IN-6 Inhibitor / Unkown
HY-A0299A H-Gly-Pro-Hyp-OH acetate Inhibitor 99.9% Unkown
HY-N4069 Lupinalbin A / Unkown
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor 99.70% Unkown
HY-Z3637 (–)-Sitagliptin carbamoyl glucuronide Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp4 NCBI NCBI:1803