Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
thigh infection
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "thigh infection" in MCE Product Catalog:
48
Target:
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
48
Target:
Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
2
Target:
Research Areas:
Ceftolozane sulfate is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane sulfate acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane sulfate can be used in studies related to bacterial infections .
2
2 Cited Publications
Target:
Research Areas:
Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections .
Cat. No.: HY-19806
CAS No.: 689293-68-3
Synonyms: CXA-101 free base; FR264205 free base
Target:
Research Areas:
Ceftolozane is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane can be used in studies related to bacterial infections .
Cat. No.: HY-B0771A
CAS No.: 113981-44-5
Synonyms: SCE-2787 hydrochloride
Research Areas:
Cefozopran (SCE-2787) hydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran hydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran hydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran hydrochloride can be used for the research of bacterial infections .
Cat. No.: HY-B0593AR
CAS No.: 78439-06-2
Synonyms: GR20263 pentahydrate (Standard)
Ceftazidime (pentahydrate) (Standard) is the analytical standard of Ceftazidime (pentahydrate). This product is intended for research and analytical applications. Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
Cat. No.: HY-B0593R
CAS No.: 72558-82-8
Synonyms: GR20263 (Standard)
Research Areas:
Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
Cat. No.: HY-106257S
Research Areas:
Ceftolozane-d6 TFA is the deuterated-labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections .
Cat. No.: HY-B0771
CAS No.: 113359-04-9
Synonyms: SCE-2787
Research Areas:
Cefozopran (SCE-2787) is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran can be used for the research of bacterial infections .
Cat. No.: HY-U00380
CAS No.: 102507-71-1
Target:
Research Areas:
Tigemonam is an orally active monobactam antibiotic with a Ki of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .
Cat. No.: HY-125356
CAS No.: 2209871-83-8
Target:
Research Areas:
ETX0282 is an orally active prodrug, with its active form being ETX1317. ETX0282 and ETX1317 are β-lactamase inhibitors of the dioxolane-dibenzo-p-heptane (DBO) type. ETX0282 exhibits high stability during intestinal absorption and can be efficiently converted into ETX1317 in the liver. ETX0282 alone has no bactericidal activity, but in a mouse model of neutropenic thigh infection, it can significantly reduce bacterial load when used in combination with Cefpodoxime Proxetil (HY-N7101). ETX0282 can be used for the study of infections caused by drug-resistant Gram-negative bacteria .
Cat. No.: HY-117951
CAS No.: 1639972-90-9
Target:
Research Areas:
ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model .
Cat. No.: HY-156122
CAS No.: 3032441-09-8
Research Areas:
DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection .
Cat. No.: HY-173472
CAS No.: 2876921-34-3
Target:
Research Areas:
MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic .
Cat. No.: HY-156123
CAS No.: 3032441-13-4
DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days) .
Cat. No.: HY-B0771AR
CAS No.: 113981-44-5
Synonyms: SCE-2787 hydrochloride (Standard)
Research Areas:
Cefozopran (SCE-2787) hydrochloride (Standard) is the analytical standard of Cefozopran hydrochloride. Cefozopran (SCE-2787) dihydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran dihydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran dihydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran dihydrochloride can be used for the research of bacterial infections .
Cat. No.: HY-W923278
CAS No.: 73547-70-3
Synonyms: GR20263 dihydrochloride
Target:
Research Areas:
Ceftazidime (GR20263) dihydrochloride is a cephalosporin β-lactam antibiotic. Ceftazidime dihydrochloride exhibits activity against susceptible Enterobacteriaceae, multidrug-resistant Gram-negative bacteria, Pseudomonas aeruginosa, and bacteria producing Ambler class A, C, and some class D β-lactamases, but shows no activity against microorganisms producing metallo-β-lactamases. Ceftazidime dihydrochloride reduces bacterial loads in mouse models of splenic, hepatic, and thigh infections, but has low efficacy against ESBL- and KPC-producing Enterobacteriaceae. Ceftazidime dihydrochloride can be used in research related to complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired pneumonia, carbapenemase-producing Klebsiella pneumoniae infections, carbapenem-resistant Enterobacterales infections, and severe Gram-negative bacterial infections .
Cat. No.: HY-182936
Target:
Research Areas:
Antibacterial agent 338 (Compound 65) is an antibacterial agent and GyrB inhibitor, with an IC50 of 12.60 nM against GyrB from E. coli. Antibacterial agent 338 binds to the ATP-binding domain of E. coli GyrB, thereby inhibiting the ATPase activity of GyrB. Antibacterial agent 338 exhibits broad-spectrum antibacterial activity against multidrug-resistant Gram-negative bacteria. Antibacterial agent 338 reduces bacterial load in a neutropenic mouse thigh infection model. Antibacterial agent 338 can be used for the research of Acinetobacter baumannii infection .
Cat. No.: HY-183512
CAS No.: 73547-61-2
Synonyms: GR20263 sodium
Target:
Research Areas:
Ceftazidime sodium (GR20263 sodium), an Antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime sodium is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
