NAMPT - nicotinamide phosphoribosyltransferase Gene

Also Known as VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10135

About NAMPT

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:106,248,298-106,285,888 (from NCBI)

This gene has 49 transcripts (splice variants), 234 orthologues and 1 paralogue. Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues.

Summary

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

NAMPT Products (4)

mRNA	Protein	Name
XM_047419700.1	XP_047275656.1	nicotinamide phosphoribosyltransferase isoform X2
NM_182790.1
XM_047419699.1	XP_047275655.1	nicotinamide phosphoribosyltransferase isoform X1
NM_005746.3	NP_005737.1	nicotinamide phosphoribosyltransferase precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16783377	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18486613	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
NOT involved in adipose tissue development	IDA IDA: Inferred from direct assay	17983582	GOA
NOT involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	17983582	GOA
involved in positive regulation of nitric-oxide synthase biosynthetic process	IDA IDA: Inferred from direct assay	19727662	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23001182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAMPT Protein Structure

NAPRTase

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
nicotinamide phosphoribosyltransferase	NAmPRTase pre-B cell-enhancing factor pre-B-cell colony-enhancing factor 1

NAMPT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NAMPT	P43490	USP49	Homo sapiens	Q70CQ1-2	Validated Y2H	32296183
Intra	NAMPT	P43490	MT-ND1	Homo sapiens	P03886	Y2H	18486613
Intra	NAMPT	P43490	MT-ND1	Homo sapiens	P03886	Anti Bait CoIP	18486613
Intra	NAMPT	P43490	NAMPT	Homo sapiens	P43490	X-Ray Diffraction	16783377
Intra	NAMPT	P43490	NAMPT	Homo sapiens	P43490	X-Ray Diffraction	19666527
Intra	NAMPT	P43490	NAMPT	Homo sapiens	P43490	Light Scattering	16783377
Intra	NAMPT	P43490	NAMPT	Homo sapiens	P43490	GMS	16783377
Intra	NAMPT	P43490	NAMPT	Homo sapiens	P43490	GMS	19666527
Intra	NAMPT	P43490	FTL	Homo sapiens	P02792	Anti Bait CoIP	18486613
Intra	NAMPT	P43490	FTL	Homo sapiens	P02792	Y2H	18486613
Intra	NAMPT	P43490	IFITM3	Homo sapiens	Q01628	Anti Bait CoIP	18486613

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NAMPT Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70353	NAMPT Protein, Human (His)	P43490 (M1-H491)	≥ 90%, as determined by reducing SDS-PAGE.

NAMPT Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81438	Visfatin Antibody (YA1183)	IHC-P	Human
HY-P81438A	Visfatin Antibody (YA1183)(PBS only)	IHC-P	Human
HY-P85319	Visfatin Antibody (YA5011)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit
HY-P85319A	Visfatin Antibody (YA5011)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Acquired Metabolic Disease
Prediabetes Syndrome	Impaired Glucose Tolerance Prediabetes Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovarian Disease Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pellagra	Niacin Deficiency Niacin-Tryptophan Deficiency Pellagroid Syndrome
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Overnutrition
Diabetes Mellitus	Diabetes
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Pericarditis
Parameningeal Embryonal Rhabdomyosarcoma
Hyperglycemia
Psoriasis 8	PSORS8 Psoriasis Susceptibility 8 Psoriasis 8, Susceptibility To
Aging
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-50876	Daporinad	Inhibitor	99.91%	Phase 2
HY-12793	Padnarsertib	Inhibitor	99.58%	Phase 2
HY-10079	CHS-828	Inhibitor	99.28%	Phase 1
HY-136241	OT-82	Inhibitor	99.95%	Phase 1
HY-10080	Teglarinad chloride	Inhibitor	99.67%	Phase 1

Pre-clinical Phase

Bioactive Molecules (75)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-126255	SBI-797812	Activator	99.88%	Unkown
HY-152154	PROTAC NAMPT Degrader-30	Degrader	99.41%	Unkown
HY-144776	NAT	Activator	99.85%	Unkown
HY-15766	GNE-617	Inhibitor	99.58%	Unkown
HY-148948	Nampt activator-3	Activator	99.71%	Unkown
HY-12808	STF-118804	Inhibitor	99.72%	Unkown
HY-12971	Nampt-IN-1	Inhibitor	99.48%	Unkown
HY-147193	Nampt-IN-10 TFA	Inhibitor	98.63%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	99.35%	Unkown
HY-402237	Nampt-IN-15	Inhibitor	99.55%	Unkown
HY-12628	GNE-618	Inhibitor	99.89%	Unkown
HY-148815	Nampt activator-1	Activator	98.63%	Unkown
HY-148822	Nampt activator-2	Activator	98.79%	Unkown
HY-P2940	NADase		/	Unkown
HY-14373	CB30865	Inhibitor	98.75%	Unkown
HY-161515	BRD4/NAMPT-IN-1	Inhibitor	99.45%	Unkown
HY-108701	Nampt-IN-3	Inhibitor	98.97%	Unkown
HY-157421	Nampt activator-4	Activator	98.87%	Unkown
HY-N3225	Myricanol	Activator	98.93%	Unkown
HY-15766A	GNE-617 hydrochloride	Inhibitor	99.16%	Unkown
HY-162537	LYP-8	Inhibitor	99.89%	Unkown
HY-14374	GPP78	Inhibitor	99.9%	Unkown
HY-130606	Nampt-IN-5	Inhibitor	98.02%	Unkown
HY-14375	CB 300919	Inhibitor	99.10%	Unkown
HY-179523	Carba1	Activator	98.23%	Unkown
HY-101280	LB-60-OF61	Inhibitor	99.25%	Unkown
HY-125147	A-1293201	Inhibitor	99.82%	Unkown
HY-101280A	LB-60-OF61 hydrochloride	Inhibitor	/	Unkown
HY-176237	Nampt-IN-16	Inhibitor	/	Unkown
HY-147756	Nampt-IN-7	Inhibitor	/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-W587952	Gibberellin A34	Inhibitor	/	Unkown
HY-147193A	Nampt-IN-10 trihydrochloride	Inhibitor	/	Unkown
HY-184247	SR-32685	Activator	/	Unkown
HY-184467	Nampt-IN-20	Inhibitor	/	Unkown
HY-181881	MV78-OH	Ligand	/	Unkown
HY-184246	SR-34831	Activator	/	Unkown
HY-164759	Nampt-IN-13	Inhibitor	/	Unkown
HY-184396	GR2-128	Inhibitor	/	Unkown
HY-159009	MS7	Inhibitor	/	Unkown
HY-119159	AS1604498	Inhibitor	/	Unkown
HY-162519	LZFPN-90	Inhibitor	/	Unkown
HY-181254	PARP1/NAMPT-IN-1	Inhibitor	/	Unkown
HY-147656	NAMPT degrader-1	Inhibitor	/	Unkown
HY-181911	L2-FK866	Inhibitor	/	Unkown
HY-182062	NAMPT activator-9	Activator	/	Unkown
HY-186105	P7C3-S243		/	Unkown
HY-161051	Anticancer agent 177	Inhibitor	/	Unkown
HY-170972	PARP1/NAMPT-IN-2	Inhibitor	/	Unkown
HY-172919	PDEδ/NAMPT IN-1	Inhibitor	/	Unkown
HY-163500	NAMPT activator-8	Activator	/	Unkown
HY-162124	HDAC/NAMPT-IN-1	Inhibitor	/	Unkown
HY-181350	CAIX/XII/NAMPT-IN-1	Inhibitor	/	Unkown
HY-158319	Mutant IDH1/NAMPT-IN-1	Inhibitor	/	Unkown
HY-50876A	Daporinad hydrochloride	Inhibitor	/	Unkown
HY-W1117786	Nampt-IN-10	Inhibitor	/	Unkown
HY-181863	Nampt-IN-18	Inhibitor	/	Unkown
HY-163440	PROTAC NAMPT Degrader-1	Degrader	/	Unkown
HY-148572	NAMPT/IDO1-IN-1	Inhibitor	/	Unkown
HY-147838	Nampt-IN-9	Inhibitor	/	Unkown
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-184650	SHP2/NAMPT-IN-1	Inhibitor	/	Unkown
HY-163280	JGB-1-155	Activator	/	Unkown
HY-187006	Nampt-IN-21	Inhibitor	/	Unkown
HY-182567	Nampt-IN-19	Inhibitor	/	Unkown
HY-181880	PROTAC NAMPT Degrader-28	Degrader	/	Unkown
HY-163499	NAMPT activator-7	Activator	/	Unkown
HY-163445	NAMPT activator-6	Activator	/	Unkown
HY-110319	(E/Z)-Daporinad hydrochloride	Inhibitor	/	Unkown
HY-147795	Nampt-IN-8	Inhibitor	/	Unkown
HY-175294	PD-L1/Nampt-IN-1	Inhibitor	/	Unkown
HY-181578	Nampt-IN-17	Inhibitor	/	Unkown
HY-10079A	CHS-828 (nicotinate)	Inhibitor	/	Unkown
HY-161180	Antitumor agent-136	Inhibitor	/	Unkown
HY-183148	NAMPT activator-10	Activator	/	Unkown

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990319	ALT-100 (Human IgG4)	Inhibitor	≥99.0%	Unkown
HY-P991075	ALT-100 (Human IgG1)	Inhibitor	99.90%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NAMPT	VGNC	VGNC:31875
Rattus norvegicus	NAMPT	RGD	RGD:631365
Felis catus	NAMPT	VGNC	VGNC:63718
Macaca mulatta	NAMPT	VGNC	VGNC:75056
Mus musculus	NAMPT	MGD	MGI:1929865
Canis familiaris	NAMPT	VGNC	VGNC:49876
Others	NAMPT	NCBI