Csf1 - colony stimulating factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78965

Summary

Enables identical protein binding activity. Involved in several processes, including myeloid leukocyte differentiation; odontogenesis; and ossification. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Csf1 Products (1)

mRNA Protein Name
NM_023981.4 NP_076471.3 macrophage colony-stimulating factor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
8357831 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
8304053 RGD
involved in macrophage differentiation IDA
IDA: Inferred from direct assay
20628067 RGD
involved in macrophage differentiation IEP
IEP: Inferred from expression pattern
12379742 RGD
involved in ossification IMP
IMP: Inferred from mutant phenotype
12379742 RGD
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12379742 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
8304053 RGD
involved in positive regulation of macrophage proliferation IMP
IMP: Inferred from mutant phenotype
8304053 RGD
involved in positive regulation of mononuclear cell migration IMP
IMP: Inferred from mutant phenotype
11499013 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
24882100 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20833686 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19219684 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular region IDA
IDA: Inferred from direct assay
16673407 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
22846308 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage colony-stimulating factor 1

  • CSF-1

  • MCSF

  • colony stimulating factor 1 (macrophage)

Recombinant Csf1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7247 M-CSF Protein, Rat (CHO) Q8JZQ0-1 (E33-P186) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7386 M-CSF Protein, Rat Q8JZQ0-1 (E33-P186) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70493 M-CSF Protein, Rat (HEK293) Q8JZQ0-1 (E33-R254) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-16749 Pexidartinib 99.64% Yes
HY-16749A Pexidartinib hydrochloride 99.82% Yes
HY-12297 Sulfatinib Inhibitor 99.52% Unkown

Clinical Phase

Bioactive Molecules (17)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-132166 Velzatinib Inhibitor 99.40% Phase 3
HY-109190 Seralutinib Inhibitor 99.94% Phase 3
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-124526 Chiauranib Inhibitor 98.97% Phase 3
HY-153920A Pimicotinib hydrochloride Inhibitor / Phase 3
HY-D3284 CSF1 / Phase 3
HY-12768 Sotuletinib Inhibitor 99.97% Phase 2
HY-109086 Edicotinib Inhibitor 99.68% Phase 2
HY-19772 GSK3117391 Inhibitor 99.40% Phase 2
HY-159838 Enrupatinib Inhibitor 98.90% Phase 2
HY-161025 SYHA1813 Inhibitor 99.46% Phase 2
HY-136362 ARRY-382 Inhibitor 99.95% Phase 2
HY-159503A Segigratinib hydrochloride Inhibitor / Phase 2
HY-114153A PLX5622 hemifumarate Inhibitor 99.93% Phase 1
HY-111787 Elzovantinib Inhibitor 99.93% Phase 1
HY-101768 PRN1371 Inhibitor 99.78% Phase 1
HY-10204 OSI-930 98.33% Phase 1
Inhibitory Antibodies (6)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P990043 Iluzanebart 98.63% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P99259 Cabiralizumab Inhibitor 99.73% Phase 2
HY-P99368 Lacnotuzumab Inhibitor 99.9% Phase 2
HY-P991048 AMG-820 Inhibitor 98% Phase 2

Pre-clinical Phase

Bioactive Molecules (71)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-114153 PLX5622 Inhibitor 99.95% Unkown
HY-50905 Dovitinib Inhibitor 99.88% Yes
HY-12768A Sotuletinib hydrochloride Inhibitor 99.43% Unkown
HY-153920 Pimicotinib Inhibitor 99.92% Unkown
HY-10408 Ki20227 Inhibitor 99.51% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.04% Unkown
HY-159108 AZ683 Inhibitor 98.57% Unkown
HY-117244 AZD7507 Inhibitor 99.57% Unkown
HY-147615 CSF1R-IN-12 98.75% Unkown
HY-122906 JTE-952 Inhibitor 99.86% Unkown
HY-152830 Adrixetinib 99.55% Unkown
HY-126297 c-Fms-IN-10 Inhibitor 98.63% Unkown
HY-139990 CSF1R-IN-3 Inhibitor 98.10% Unkown
HY-145809 FASN-IN-5 Inhibitor 99.98% Unkown
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.88% Unkown
HY-132935 BPR1R024 Inhibitor 98.50% Unkown
HY-160842 CSF1R-IN-24 Inhibitor 98.10% Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-119942 c-Fms-IN-8 Inhibitor 99.50% Unkown
HY-152830A Adrixetinib TFA 99.82% Unkown
HY-101526 GENZ-882706 Inhibitor / Unkown
HY-13075 c-Fms-IN-3 Inhibitor 98.83% Unkown
HY-132935A BPR1R024 mesylate Inhibitor / Unkown
HY-RS03228 CSF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493 AC710 Inhibitor 99.57% Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-RS16853 Csf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown
HY-12768B Sotuletinib dihydrochloride Inhibitor / Unkown
HY-174366 JMC14 Inhibitor / Unkown
HY-10109A AS-605240 potassium Inhibitor / Unkown
HY-109086A Edicotinib hydrochloride Inhibitor / Unkown
HY-112446 ST638 Inhibitor / Unkown
HY-13496A JNJ-28312141 hydrochloride Inhibitor / Unkown
HY-144040 CSF1R-IN-4 / Unkown
HY-144041 CSF1R-IN-5 Inhibitor / Unkown
HY-144042 CSF1R-IN-6 / Unkown
HY-147608 CSF1R-IN-7 Inhibitor / Unkown
HY-147609 CSF1R-IN-8 Inhibitor / Unkown
HY-147610 CSF1R-IN-9 Inhibitor / Unkown
HY-147611 CSF1R-IN-10 Inhibitor / Unkown
HY-147616 CSF1R-IN-13 / Unkown
HY-147617 CSF1R-IN-14 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-153243 IACS-9439 Inhibitor / Unkown
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / Unkown
HY-155001 CSF1R-IN-15 Inhibitor / Unkown
HY-155550 CSF1R-IN-17 Antagonist / Unkown
HY-157422 CSF1R-IN-19 Inhibitor / Unkown
HY-157996 CSF1R-IN-21 Inhibitor / Unkown
HY-158050 PXB17 Inhibitor / Unkown
HY-158148 CSF1R-IN-23 Inhibitor / Unkown
HY-158363 CSF1R-IN-25 Inhibitor / Unkown
HY-161084 CSF1R-IN-18 Inhibitor / Unkown
HY-162309 CSF1R-IN-20 Inhibitor / Unkown
HY-162415 CSF1R-IN-22 / Unkown
HY-168954 CSF1R-IN-26 / Unkown
HY-176194 Antifibrotic agent 1 / Unkown
HY-183569 CSF1R-IN-27 Inhibitor / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-187340 CSF1R/c-Kit-IN-1 Inhibitor / Unkown
HY-187341 CSF1R/c-Kit-IN-2 Inhibitor / Unkown
HY-D3217 Ctrl-CSF1 / Unkown
HY-RS03227 CSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-174606 Human IL34 mRNA / Unkown
HY-174734 Human CSF1 mRNA / Unkown
HY-RS23294 Csf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990125 Anti-Mouse CSF1R/CD115 Antibody (AFS98) 99.38% Unkown
HY-P990257 Anti-Mouse CSF1 Antibody (5A1) Inhibitor 96.799% Unkown
HY-P990849 Anti-CSF1R/CD115 Antibody (2-4A5-4) Inhibitor / Unkown
HY-P991313 PD-360324 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf1 NCBI NCBI:1435