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Sapanisertib

(Synonyms: INK-128; MLN0128; TAK-228)
56 Cited Publications
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Based on 56 publication(s) in Google Scholar

Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.

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  • Pureté: 99.78%
  • CAS No.: 1224844-38-5
  • Formule: C15H15N7O
  • Masse moléculaire:309.33
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Sapanisertib Chemical Structure
    Sapanisertib Chemical Structure
  • Experimental Validation Results for Sapanisertib
  • Experimental Validation Results for Sapanisertib
  • Experimental Validation Results for Sapanisertib
  • Experimental Validation Results for Sapanisertib
CAS No.: 1224844-38-5
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  • Sapanisertib Chemical Structure
    Sapanisertib Chemical Structure
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    Sapanisertib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 Jun 8;8:15617. [Abstract]

    Customer Validation
     Immunoblot analysis of KRAS protein levels in parental (P) and resistant derivatives (R1 and R2) following 4 h treatment with the corresponding inhibitor MLN0128 (Sapanisertib).

  • 1/16

    Sapanisertib purchased from MedChemExpress. Usage Cited in: Oncogene. 2015 Mar 26;34(13):1729-35. [Abstract]

    Customer Validation
     INK-128 ablates phosphorylation of the mTORC1 substrates, 4E-BP1 and S6K.

  • 1/16

    Sapanisertib purchased from MedChemExpress. Usage Cited in: J Virol. 2014 Oct;88(20):11872-85. [Abstract]

    Customer Validation
     Representative Western blot from two independent experiments of p-Akt, p-mTOR, mTOR, p-4EBP1, 4EBP1, eIF4E, c-myc, and MTA1 genes in CNE-1-LMP2A cells treated with Rapamycin (50 nM) or INK-128 (200 nM) for 24 h. The quantification of the Western blot signals are analyzed.

  • 1/16

    Sapanisertib purchased from MedChemExpress. Usage Cited in: J Virol. 2014 Oct;88(20):11872-85. [Abstract]

    Customer Validation
     Confocal analysis of MTA1 (red) and β-catenin (green) expression in CNE-1-LMP2A cells treated with Rapamycin (50 nM) or INK-128 (200 nM) for 24 h. The scale bar represents 10 μm. Immunofluorescence analysis of MTA1 and β-catenin expression reveals that MTA1 is decreased and β-catenin is maintained in the cytoplasm when the cells are treated with INK-128.

  • Sapanisertib