EGF - epidermal growth factor Gene
Also Known as URG; HOMG4
Species: Homo sapiens
About EGF
This gene has 13 transcripts (splice variants), 188 orthologues, 14 paralogues and is associated with 3 phenotypes. Biased expression in kidney (RPKM 47.7), pancreas (RPKM 9.8) and 1 other tissue.
Summary
This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
EGF Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001178130.3 | NP_001171601.1 | pro-epidermal growth factor isoform 2 precursor |
| NM_001178131.3 | NP_001171602.1 | pro-epidermal growth factor isoform 3 precursor |
| NM_001357021.2 | NP_001343950.1 | pro-epidermal growth factor isoform 4 precursor |
| NM_001963.6 | NP_001954.2 | pro-epidermal growth factor isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
7736574 | GOA |
| enables guanyl-nucleotide exchange factor activity |
IDA
IDA: Inferred from direct assay
|
20353436 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
2790960 | GOA |
| enables receptor ligand activity |
IDA
IDA: Inferred from direct assay
|
11336639 | GOA |
| enables transmembrane receptor protein tyrosine kinase activator activity |
IDA
IDA: Inferred from direct assay
|
11336639 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
21082674 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
11336639 | GOA |
EGF Protein Structure
EGF_CA: Calcium-binding EGF domain (356 - 395)
FXa_inhibition: Coagulation Factor Xa inhibitory site (439 - 476)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (524 - 564)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (568 - 607)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (611 - 650)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (654 - 693)
FXa_inhibition: Coagulation Factor Xa inhibitory site (745 - 780)
EGF_CA: Calcium-binding EGF domain (870 - 910)
EGF_CA: Calcium-binding EGF domain (912 - 941)
EGF: EGF-like domain (981 - 1011)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1207 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
pro-epidermal growth factor |
|
EGF Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
EGF | P01133 | MGST1 | Homo sapiens | P10620 | 32296183 | |
|
Intra
|
EGF | P01133 | MGST1 | Homo sapiens | P10620 | 32296183 | |
|
Intra
|
EGF | P01133 | MGST1 | Homo sapiens | P10620 | 32296183 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 12620237 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 30083275 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 12297050 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 9135143 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 2790960 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 28988771 | |
|
Intra
|
EGF | P01133 | EGFR | Homo sapiens | P00533 | 21439278 | |
|
Cross
|
EGF | P01133 | Egfr | Mus musculus | Q01279 | 21439278 |
Recombinant EGF Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P7109 | EGF Protein, Human | P01133-1 (N971-R1023) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72982 | EGF Protein, Human (HEK293, N-hFc, solution) | NP_001954.2 (N971-R1023) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P7109G | GMP EGF Protein, Human | P01133-1 (N971-R1023) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700051AF | Animal-Free EGF Protein, Human (His) | P01133-1 (N971-R1023) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72982A | EGF Protein, Human (HEK293, N-hFc) | NP_001954.2 (N971-R1023) | ≥ 90%, as determined by reducing SDS-PAGE. |
EGF Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80115 | EGF Antibody (YA469) | WB, IHC-P, IP | Human |
| HY-P83900 | EGF Antibody (YA3597) | ICC/IF, ELISA | Human |
| HY-P83900A | EGF Antibody (YA3597)(PBS only) | ICC/IF, ELISA | Human |
| HY-P85130 | EGF Antibody (YA4822) | WB, ICC/IF, ELISA | Human |
| HY-P85619 | EGF Antibody (YA5311) | ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypomagnesemia 4, Renal |
|
|
| Egf-Related Primary Hypomagnesemia With Intellectual Disability |
|
|
| Adult Hepatocellular Carcinoma |
|
|
| Breast Cyst |
|
|
| Short Bowel Syndrome |
|
|
| Otorrhea |
|
|
| Mal De Meleda |
|
|
| Factor Vii Deficiency |
|
|
| Cerebral Meningioma |
|
|
| Chronic Ulcer Of Skin |
|
|
| Cholera |
|
|
| Gastric Ulcer |
|
|
| Adenocarcinoma |
|
|
| Endometrial Cancer |
|
|
| Perinatal Necrotizing Enterocolitis |
|
|
| Pertussis |
|
|
| Breast Disease |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Pancreatic Cancer |
|
|
| Colorectal Cancer |
|
|
| Cholesteatoma Of Middle Ear |
|
|
| Breast Cancer |
|
|
| Diphtheria |
|
|
| Lung Cancer |
|
|
| Donohue Syndrome |
|
|
| Microvillus Inclusion Disease |
|
|
| Bladder Cancer |
|
|
| Brain Cancer |
|
|
| Zollinger-Ellison Syndrome |
|
|
| Choriocarcinoma |
|
|
| Folliculitis |
|
|
| Squamous Cell Carcinoma |
|
|
| Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1 |
|
|
| Leiomyoma |
|
|
| Glioblastoma |
|
|
| Hydronephrosis |
|
|
| Costello Syndrome |
|
|
| Cystitis |
|
|
| Bladder Exstrophy |
|
|
| Pheochromocytoma |
|
|
| Mucositis |
|
|
| Familial Hypercholesterolemia |
|
|
| Hypersplenism |
|
|
| Duodenal Ulcer |
|
|
| Polycystic Kidney Disease |
|
|
| Glioma |
|
|
| Axenfeld-Rieger Syndrome |
|
|
| Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease |
|
|
| Obstructive Nephropathy |
|
|
| Thrombasthenia |
|
|
| Marfan Syndrome |
|
|
| Ovarian Cancer |
|
|
| Prostate Cancer |
|
|
| Gastroesophageal Reflux |
|
|
| Colon Adenocarcinoma |
|
|
| Cholecystitis |
|
|
| Mixed Cell Adenoma |
|
|
| Cystic Kidney Disease |
|
|
| Bile Duct Cancer |
|
|
| Gastric Cancer |
|
|
| Gingival Overgrowth |
|
|
| Insulin-Like Growth Factor I |
|
|
| Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease |
|
|
| Homocystinuria |
|
|
| Histoplasmosis |
|
|
| Prolactinoma |
|
|
| High Grade Glioma |
|
|
| Gastrointestinal Carcinoma |
|
|
| Papilloma |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Meningioma, Familial |
|
|
| Breast Carcinoma In Situ |
|
|
| Kidney Cancer |
|
|
| Psoriasis |
|
|
| Tongue Carcinoma |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Punctate Epithelial Keratoconjunctivitis |
|
|
| Pre-Malignant Neoplasm |
|
|
| Keratopathy |
|
|
| Breast Lobular Carcinoma |
|
|
| Ductal Carcinoma In Situ |
|
|
| In Situ Carcinoma |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Osteogenic Sarcoma |
|
|
| Spondylocostal Dysostosis 3, Autosomal Recessive |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Deafness, Autosomal Dominant 56 |
|
|
| Paronychia |
|
|
| Hepatoblastoma |
|
|
| Lung Carcinoma In Situ |
|
|
| Doyne Honeycomb Retinal Dystrophy |
|
|
| Decubitus Ulcer |
|
|
| Breast Adenocarcinoma |
|
|
| Alcohol Dependence |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Non-Syndromic X-Linked Intellectual Disability 96 |
|
|
| Corneal Ulcer |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Pulmonary Adenocarcinoma In Situ |
|
|
| Recessive Dystrophic Epidermolysis Bullosa |
|
|
| Lacrimal Apparatus Disease |
|
|
| Brain Glioblastoma Multiforme |
|
|
| Adams-Oliver Syndrome |
|
|
| Medulloblastoma |
|
|
| Dry Eye Syndrome |
|
|
| Neuroblastoma |
|
|
| Cataract |
|
|
| Breast Benign Neoplasm |
|
|
| Myelodysplastic Syndrome |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Thoracic Benign Neoplasm |
|
|
| Hennekam Syndrome |
|
|
| Hepatocellular Carcinoma |
|
|
| Colon Adenoma |
|
|
| Inflammatory Bowel Disease |
|
|
| Estrogen-Receptor Positive Breast Cancer |
|
|
| Corneal Disease |
|
|
| Osteoporosis |
|
|
| Intestinal Benign Neoplasm |
|
|
| Esophageal Cancer |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Cystic Fibrosis |
|
|
| Colorectal Adenocarcinoma |
|
|
| Brain Glioma |
|
|
| Oropharynx Cancer |
|
|
| Dowling-Degos Disease |
|
|
| Cerebral Degeneration |
|
|
| Infratentorial Cancer |
|
|
| Colonic Benign Neoplasm |
|
|
| Junctional Epidermolysis Bullosa |
|
|
| Aortic Valve Disease 1 |
|
|
| Distal Arthrogryposis |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Diabetes Mellitus |
|
|
| Rasopathy |
|
|
| Lymphangioma |
|
|
| Head And Neck Cancer |
|
|
| Schizophrenia |
|
|
| Malignant Astrocytoma |
|
|
| Prolapse Of Urethra |
|
|
| Amelogenesis Imperfecta |
|
|
| Pyriform Sinus Cancer |
|
|
| Gliosarcoma |
|
|
| Hypertension, Essential |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Peripheral Nervous System Disease |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Eye Disease |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Skin Disease |
|
|
| Connective Tissue Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Nervous System Disease |
|
|
| Noonan Syndrome 1 |
|
|
| Hirschsprung Disease 1 |
|
|
| Leukemia, Acute Myeloid |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Retinitis Pigmentosa |
|
|
| Congenital Nervous System Abnormality |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | EGF | VGNC | VGNC:72171 |
| Canis familiaris | EGF | VGNC | VGNC:40235 |
| Rattus norvegicus | EGF | RGD | RGD:2542 |
| Felis catus | EGF | VGNC | VGNC:61755 |
| Mus musculus | EGF | MGD | MGI:95290 |
| Others | EGF | NCBI |