HDAC4 - histone deacetylase 4 Gene

Also Known as HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9759

About HDAC4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:239,048,168-239,401,649 (from NCBI)

This gene has 18 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 5 phenotypes. Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 1.6) and 24 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

HDAC4 Products (42)

mRNA	Protein	Name
XM_006712877.4	XP_006712940.1	histone deacetylase 4 isoform X2
XM_047446498.1	XP_047302454.1	histone deacetylase 4 isoform X29
XM_047446487.1	XP_047302443.1	histone deacetylase 4 isoform X18
XM_047446493.1	XP_047302449.1	histone deacetylase 4 isoform X24
XM_047446497.1	XP_047302453.1	histone deacetylase 4 isoform X28
XM_011512224.3	XP_011510526.1	histone deacetylase 4 isoform X11
XM_011512225.3	XP_011510527.1	histone deacetylase 4 isoform X13
XM_047446495.1	XP_047302451.1	histone deacetylase 4 isoform X26
XM_047446486.1	XP_047302442.1	histone deacetylase 4 isoform X17
XM_047446489.1	XP_047302445.1	histone deacetylase 4 isoform X20
XM_047446478.1	XP_047302434.1	histone deacetylase 4 isoform X8
XM_047446484.1	XP_047302440.1	histone deacetylase 4 isoform X14
XM_011512218.3	XP_011510520.1	histone deacetylase 4 isoform X3
XM_024453257.2	XP_024309025.1	histone deacetylase 4 isoform X19
XM_011512219.3	XP_011510521.1	histone deacetylase 4 isoform X4
XM_006712880.4	XP_006712943.1	histone deacetylase 4 isoform X19
XM_011512227.3	XP_011510529.1	histone deacetylase 4 isoform X23
XM_011512222.4	XP_011510524.1	histone deacetylase 4 isoform X6
XM_047446488.1	XP_047302444.1	histone deacetylase 4 isoform X19
XM_047446496.1	XP_047302452.1	histone deacetylase 4 isoform X27
XM_011512223.3	XP_011510525.1	histone deacetylase 4 isoform X6
XM_047446482.1	XP_047302438.1	histone deacetylase 4 isoform X14
NM_001378417.1	NP_001365346.1	histone deacetylase 4 isoform 2
XM_047446483.1	XP_047302439.1	histone deacetylase 4 isoform X14
NM_001378416.1	NP_001365345.1	histone deacetylase 4 isoform 2
XM_047446485.1	XP_047302441.1	histone deacetylase 4 isoform X15
XM_047446491.1	XP_047302447.1	histone deacetylase 4 isoform X21
NM_006037.4	NP_006028.2	histone deacetylase 4 isoform 2
XM_011512226.3	XP_011510528.1	histone deacetylase 4 isoform X17
XM_011512217.3	XP_011510519.1	histone deacetylase 4 isoform X1
XM_047446477.1	XP_047302433.1	histone deacetylase 4 isoform X7
XM_011512220.3	XP_011510522.1	histone deacetylase 4 isoform X5
XM_047446490.1	XP_047302446.1	histone deacetylase 4 isoform X20
XM_047446479.1	XP_047302435.1	histone deacetylase 4 isoform X9
XM_047446492.1	XP_047302448.1	histone deacetylase 4 isoform X22
XM_047446480.1	XP_047302436.1	histone deacetylase 4 isoform X10
XM_047446494.1	XP_047302450.1	histone deacetylase 4 isoform X25
XM_017005394.2	XP_016860883.1	histone deacetylase 4 isoform X16
NM_001378414.1	NP_001365343.1	histone deacetylase 4 isoform 1
NM_001378415.1	NP_001365344.1	histone deacetylase 4 isoform 1
XM_047446476.1	XP_047302432.1	histone deacetylase 4 isoform X6
XM_047446481.1	XP_047302437.1	histone deacetylase 4 isoform X12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10983972	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18850004	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	17218271	GOA
contributes to histone binding	IDA IDA: Inferred from direct assay	19276356	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10220385	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17360518	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	31127039	GOA
enables potassium ion binding	IDA IDA: Inferred from direct assay	18614528	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18614528	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18850004	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18614528	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	18850004	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	10983972	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16236793	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10869435	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15743821	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	19276356	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: Inferred from direct assay	18614528	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	17696781	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	27708256	GOA
involved in regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	19281832	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	31127039	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	31127039	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11804585	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10869435	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	11804585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC4 Protein Structure

HDAC4_Gln

Hist_deacetyl

Arb2

0
200
400
600
800
1000
1084 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 4	histone deacetylase A

HDAC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HDAC4	P56524	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	HDAC4	P56524	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	HDAC4	P56524	ATF2	Homo sapiens	P15336	Anti Bait CoIP	20116378
Intra	HDAC4	P56524	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	HDAC4	P56524	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	HDAC4	P56524	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	HDAC4	P56524	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Pull Down	11504882
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Validated Y2H	25416956
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	17159145
Intra	HDAC4	P56524	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	CoIP	18045992
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAB	Homo sapiens	P31946	CoIP	10958686
Intra	HDAC4	P56524	YWHAQ	Homo sapiens	P27348	CoIP	18045992
Intra	HDAC4	P56524	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	MIF4GD	Homo sapiens	A9UHW6	Pull Down	21988832
Intra	HDAC4	P56524	MIF4GD	Homo sapiens	A9UHW6	Confocal	21988832
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	Y2H	16767219
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	TAP	15778465
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	AR	Homo sapiens	P10275	Anti Bait CoIP	21242980
Intra	HDAC4	P56524	AR	Homo sapiens	P10275	Pull Down	21242980
Intra	HDAC4	P56524	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	HDAC4	P56524	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	16919237
Intra	HDAC4	P56524	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Validated Y2H	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Y2H Array	25416956
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Pull Down	17159145
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Tag CoIP	17159145
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	17159145
Cross	HDAC4	P56524	ICP0	Human herpesvirus 1	P08393	Pull Down	15194749
Cross	HDAC4	P56524	ICP0	Human herpesvirus 1	P08393	CoIP	15194749

Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80153	HDAC4 Antibody (YA391)	WB, ICC/IF	Human
HY-P80700	HDAC4 Antibody (YA741)	WB, IP	Human, Mouse, Rat, Monkey
HY-P80700A	HDAC4 Antibody (YA741)(PBS only)	WB, IP	Human, Mouse, Rat, Monkey
HY-P84412	HDAC4 Antibody (YA4109)	ICC/IF, FC, ELISA	Human
HY-P84412A	HDAC4 Antibody (YA4109)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P86323	HDAC4 Antibody (YA6015)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Muscle Hypertrophy	MSLHP Hypertrophy, Muscle Hypertrophy
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies	NEDCHF
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Brachydactyly
Chromosome 2q37 Deletion Syndrome	Albright Hereditary Osteodystrophy-Like Syndrome 2q37 Microdeletion Syndrome Brachydactyly-Intellectual Disability Syndrome Deletion 2q37 2q37 Deletion Syndrome Brachydactyly-Mental Retardation Syndrome Bdmr Albright Hereditary Osteodystrophy Type 3 Del(2)(Q37) Monosomy 2q37qter Albright'S Hereditary Osteodystrophy-Like Syndrome Monosomy 2q37 Chromosome Deletion Syndrome 2q37
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.70%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.82%	Unkown
HY-13428	Tubacin	Inhibitor	97.11%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-18360	TMP269	Inhibitor	98.16%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-19350	BML-210	Inhibitor	98.04%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.10%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.91%	Unkown
HY-169259	HDAC9-IN-1	Inhibitor	95.13%	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-W039803	HDAC4 ligand-2	Ligand	/	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	98.11%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-184524	PROTAC HDAC4 Degrader-2		/	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-179321	PROTAC HDAC4 Degrader-1	Degrader	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-178022	HDAC6-IN-63	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-163143	HDAC8-IN-6	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-181086	FLT3/HDAC-IN-3	Inhibitor	/	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-172159	FF2039	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-181579	HDAC6-IN-74	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown
HY-180214	HDAC6-IN-69	Inhibitor	/	Unkown
HY-179227	HDAC6 ligand-7	Inhibitor	/	Unkown
HY-182747	HDAC6-IN-79	Inhibitor	/	Unkown
HY-P2044	Azumamide E	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HDAC4	RGD	RGD:619979
Macaca mulatta	HDAC4	VGNC	VGNC:82155
Felis catus	HDAC4	VGNC	VGNC:62767
Mus musculus	HDAC4	MGD	MGI:3036234
Canis familiaris	HDAC4	VGNC	VGNC:50629
Bos taurus	HDAC4	VGNC	VGNC:50611
Others	HDAC4	NCBI