2. Gene
  3. GCGR - glucagon receptor Gene

GCGR - glucagon receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Sus scrofa
Gene ID: 110255938 | Gene type: protein coding

About GCGR

Primary_assembly 12: 1,146,069-1,157,234 reverse strand.Sscrofa11.1:CM000823.5

This gene has 3 transcripts (splice variants), 184 orthologues and 47 paralogues. Biased expression in liver (RPKM 36.), mixtures (RPKM 14.6) and 2 other tissues.

GCGR Products(8)

mRNA Protein Name
XM_021066444.1 XP_020922103.1 glucagon receptor isoform X4
XM_021066445.1 XP_020922104.1 glucagon receptor isoform X5
XM_021066448.1 XP_020922107.1 glucagon receptor isoform X8
XM_021066443.1 XP_020922102.1 glucagon receptor isoform X3
XM_021066447.1 XP_020922106.1 glucagon receptor isoform X7
XM_021066441.1 XP_020922100.1 glucagon receptor isoform X1
XM_021066442.1 XP_020922101.1 glucagon receptor isoform X2
XM_021066446.1 XP_020922105.1 glucagon receptor isoform X6

GCGR Protein Structure

HRM

HRM: pfam02793 (32 - 133)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (146 - 523)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (149 - 174)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (183 - 205)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (234 - 261)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (273 - 293)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (309 - 435)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (451 - 476)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (485 - 510)

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  • 586 a.a.
Protein Preferred Names Protein Names

glucagon receptor

Related Agents

Approval
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13443 Exendin-4 Agonist 99.89% Unkown
HY-P0014 Liraglutide Agonist 99.95% Unkown
HY-112185 Orforglipron Agonist 99.64% Unkown
HY-P0082 Glucagon (1-29), bovine, human 99.91% Unkown
HY-P0120 Dulaglutide Agonist 96% Unkown
HY-P0082A Glucagon (1-29), bovine, human hydrochloride 99.89% Unkown
HY-13443A Exendin-4 acetate Agonist 99.87% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.71% Unkown
HY-P3469A Dasiglucagon acetate 98.66% Unkown
HY-P3469 Dasiglucagon Agonist / Unkown
Clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Phase
HY-P3463 Beinaglutide 98.49% Phase 4
HY-P4146 Survodutide Agonist 99.92% Phase 3
HY-P0165 Taspoglutide Agonist 99.43% Phase 3
HY-P2221B Glepaglutide acetate Agonist 99.48% Phase 3
HY-P4146A Survodutide TFA Agonist 99.39% Phase 3
HY-P3375A Mazdutide TFA Agonist 99.67% Phase 3
HY-P2221 Glepaglutide Agonist 99.53% Phase 3
HY-112668B Retagliptin hydrochloride / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-50663 MK 0893 Antagonist 99.83% Phase 2
HY-19904 Adomeglivant Antagonist 99.63% Phase 2
HY-P2231A Cotadutide acetate Agonist 99.30% Phase 2
HY-12525 LGD-6972 Antagonist 98.0% Phase 2
HY-19947 PF-06291874 Antagonist 99.31% Phase 2
HY-P10018 Bamadutide Agonist 99.94% Phase 2
HY-P3498 Elsiglutide Agonist 99.64% Phase 2
HY-P10031 SAR441255 Agonist 99.77% Phase 1
HY-P10031A SAR441255 TFA 99.93% Phase 1
HY-19374 BAY-27-9955 Antagonist / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99383 Volagidemab Antagonist ≥99.0% Phase 2
HY-P99357 Crotedumab Inhibitor 99.22% Phase 1
Pre-clinical Phase
Bioactive Molecules (151)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3506 Retatrutide Agonist 99.96% Unkown
HY-P0055 GLP-1(7-37) 99.89% Unkown
HY-P0054 GLP-1(7-36), amide acetate 99.01% Unkown
HY-P3375 Mazdutide Agonist 99.94% Unkown
HY-121835 GLP-1R agonist 2 Agonist 99.57% Unkown
HY-P1141 GLP-1(9-36)amide Antagonist 99.69% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% Unkown
HY-P0054A GLP-1(7-36), amide Agonist 99.90% Unkown
HY-P0055A GLP-1(7-37) acetate 99.59% Unkown
HY-P11274A Zenagamtide sodium Agonist 99.96% Unkown
HY-103546 BETP Agonist 99.48% Unkown
HY-P3506A Retatrutide TFA Agonist 99.05% Unkown
HY-P1024 GLP-2(1-33)(human) Agonist 98.43% Unkown
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% Unkown
HY-P0054B GLP-1(7-36), amide TFA 98.82% Unkown
HY-P1160 Bay 55-9837 Agonist 99.56% Unkown
HY-124622 NNC-0640 Modulator 98.43% Unkown
HY-P1023 VIP(6-28)(human, rat, porcine, bovine) Antagonist 98.09% Unkown
HY-129658A TT-OAD2 Agonist 99.59% Unkown
HY-P3291 Dapiglutide Agonist 98.52% Unkown
HY-P3366 Ecnoglutide Agonist 99.93% Unkown
HY-P10736 AMG133 peptide payload 99.94% Unkown
HY-P2231 Cotadutide Agonist 99.11% Unkown
HY-10930 UNC0321 Inhibitor 99.91% Unkown
HY-142162 LSN3318839 Modulator 99.22% Unkown
HY-P0014S1 Liraglutide-13C5,15N tetraTFA Agonist 97.74% Unkown
HY-P0150 Glucagon (19-29), human Inhibitor 99.11% Unkown
HY-P2625 GLP-2(3-33) Agonist 99.82% Unkown
HY-P1144 Oxyntomodulin (bovine, porcine) Agonist 99.77% Unkown
HY-P1145A Glucagon-like peptide 1 (1-37), human TFA Agonist 98.36% Unkown
HY-P3101 GLP-1(28-36)amide 99.18% Unkown
HY-P1348 GLP-1 moiety from Dulaglutide 99.60% Unkown
HY-116819 VU0453379 Modulator 98.0% Unkown
HY-103547 L-168049 Antagonist 99.94% Unkown
HY-145632 Pemvidutide Agonist 99.40% Unkown
HY-N0630 Shanzhiside methyl ester Agonist 99.97% Unkown
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 98.36% Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.61% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-P10032 NN1177 Agonist 99.54% Unkown
HY-P3102 GLP-1(32-36)amide 98.44% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.81% Unkown
HY-50159 Glucagon receptor antagonist-3 Antagonist 99.78% Unkown
HY-50675 GRA Ex-25 Inhibitor 99.07% Unkown
HY-148212 GLP-1R agonist 17 Agonist 99.82% Unkown
HY-P10019 Pegsebrenatide Agonist 95.50% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 99.47% Unkown
HY-P10032A NN1177 TFA Agonist 99.22% Unkown
HY-P5815 GLP-1 (1-36) amide (human, rat) 98.10% Unkown
HY-116854 NNC 92-1687 Antagonist 98.74% Unkown
HY-50158 Glucagon receptor antagonist-2 Antagonist 99.23% Unkown
HY-P3617 Glucagon (22-29) Agonist 98.12% Unkown
HY-148844 GCGR antagonist 2 Antagonist 98.17% Unkown
HY-145632A Pemvidutide TFA Antagonist 98.07% Unkown
HY-13443B Exendin-4-Lys-azide TFA Agonist 96.88% Unkown
HY-P5815A GLP-1 (1-36) amide (human, rat) TFA 98.02% Unkown
HY-P3622 (Ser8)-GLP-1 (7-36) amide, human Agonist 99.10% Unkown
HY-P1145 Glucagon-like peptide 1 (1-37), human Agonist 99.70% Unkown
HY-153476A GIP/GLP-1 dual receptor agonist-1 sodium Agonist 98.33% Unkown
HY-141839 GLP-1R modulator C16 Modulator 98.67% Unkown
HY-P1228 HAEGTFT 98.81% Unkown
HY-124803 GPCR modulator-1 Modulator / Unkown
HY-P4146B Survodutide sodium Agonist / Unkown
HY-P3491 Pegloxenatide Agonist 90.00% Unkown
HY-P1227 SDV-Exendin-3/4 95.96% Unkown
HY-P1229 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01% Unkown
HY-10036 Glucagon receptor antagonist-1 Antagonist 98.65% Unkown
HY-P5074 GRPP (human) Agonist 98.94% Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-P1226 HAEGTFTSD Agonist 98.48% Unkown
HY-P11237 Enicepatide Agonist / Unkown
HY-P10341 ZP3022 Agonist 98.00% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-P1223 Exendin-3/4 (59-86) 98.19% Unkown
HY-P1224 HAEGTFTSDVS 98.62% Unkown
HY-P1231 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03% Unkown
HY-116819A VU0453379 hydrochloride Modulator 99.0% Unkown
HY-119739 Skyrin Antagonist 97.0% Unkown
HY-P2497 Exendin (5-39) Antagonist 99.43% Unkown
HY-P1225 {Val1}-Exendin-3/4 99.45% Unkown
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist 99.32% Unkown
HY-108795B [Gly8]-GLP-1(7-37) acetate Agonist 99.11% Unkown
HY-142162A (S,R)-LSN3318839 Control 98.25% Unkown
HY-P11274 Zenagamtide Agonist / Unkown
HY-128781 Glucagon receptor antagonist-5 Antagonist / Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-172811 DA-302168S Agonist / Unkown
HY-107129 MK-3577 Antagonist / Unkown
HY-120401 Glybuzole Activator / Unkown
HY-P0212 Neuropeptide Y, porcine Agonist / Unkown
HY-181709 TPM003 Agonist / Unkown
HY-P0212A Neuropeptide Y, porcine TFA / Unkown
HY-128103 Glucagon receptor antagonist-7 Antagonist / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-172673 GLP-1R agonist 31 Agonist / Unkown
HY-P1543 Exendin-3 Antagonist 98.31% Unkown
HY-171851 GLP-1R agonist 32 Agonist / Unkown
HY-159696A ISIS 449884 sodium Inhibitor / Unkown
HY-169707 GCGR antagonist 3 Antagonist / Unkown
HY-129656 GLP-1 receptor agonist 3 Agonist / Unkown
HY-12525B LGD 6972 ammonium Antagonist / Unkown
HY-P1144A Oxyntomodulin (bovine, porcine) TFA Agonist / Unkown
HY-D3173 TP-α / Unkown
HY-P11487 UTG-4 Agonist / Unkown
HY-P2625S1 GLP-2(3-33) (Leu-13C6,15N) TFA Agonist / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-P4672 (Met(O)27)-Glucagon (1-29) (human, rat, porcine) / Unkown
HY-106559 Sorbinicate Inhibitor / Unkown
HY-P5161 FC382K10W15 Agonist / Unkown
HY-P3101A GLP-1(28-36)amide TFA / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-P3050 Helospectin II Inhibitor / Unkown
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-P0211 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Antagonist / Unkown
HY-P3102A GLP-1(32-36)amide TFA / Unkown
HY-P3621 Biotinyl-Glucagon (1-29), human, bovine, porcine / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-P3616 Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide / Unkown
HY-P11275 TC4 Agonist / Unkown
HY-P5578A A8SGLP-1 TFA Agonist / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-P1160A Bay 55-9837 TFA / Unkown
HY-P4843 Gastric Inhibitory Polypeptide (6-30) amide (human) / Unkown
HY-P4503 (D-His1)-Exenatide Control / Unkown
HY-13443S Exendin-4 (Leu-13C6,15N) TFA / Unkown
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / Unkown
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / Unkown
HY-P5578 A8SGLP-1 Agonist / Unkown
HY-159696B ISIS 449884 sodium scrambled negative control Inhibitor / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-13443F Exendin 4, biotin labeled Agonist / Unkown
HY-P3053 Helospectin I / Unkown
HY-159696 ISIS 449884 Inhibitor / Unkown
HY-P2880 PHI-27 (porcine) / Unkown
HY-P10337 OXM-7 Agonist / Unkown
HY-P4459 (Des-Gly2)-Exenatide Control / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-177156 Glucagon receptor antagonist-8 Antagonist / Unkown
HY-P11044 GEP12 Agonist / Unkown
HY-P11279 TC2 Agonist / Unkown
HY-129658 TT-OAD2 free base Agonist / Unkown
HY-12525A LGD-6972 sodium Antagonist / Unkown
HY-125824A Danuglipron tromethamine Agonist / Unkown
HY-180444 Glucagon receptor antagonist-9 Antagonist / Unkown
HY-180446 Glucagon receptor antagonist-11 Antagonist / Unkown
HY-118914 Glucagon receptor antagonist inactive control Control / Unkown
HY-12735 SCH 900822 Antagonist / Unkown
HY-180445 Glucagon receptor antagonist-10 Antagonist / Unkown
HY-160281 CCD-2 / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor 95.481% Unkown
HY-P991099 Anti-GLP1R Antibody Inhibitor 97.19% Unkown
HY-P992007 PF-06293620 Antagonist / Unkown
HY-P992006 Anti-Glucagon Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GCGR NCBI NCBI:2642
Mus musculus GCGR NCBI NCBI:14527
Rattus norvegicus GCGR NCBI NCBI:24953