Cdk7 - cyclin-dependent kinase 7 Gene

Also Known as CAK; Crk4; Cdkn7; P39 Mo15; C230069N13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12572

About Cdk7

Chromosome 13: 100,839,139-100,867,447 reverse strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 213 orthologues, 25 paralogues and is associated with 4 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 4.4) and 28 other tissues.

Summary

Enables protein kinase activity. Predicted to be involved in protein stabilization; regulation of transcription by RNA polymerase II; and transcription initiation from RNA polymerase II promoter. Predicted to act upstream of or within DNA repair; cell division; and phosphorylation. Located in nucleus. Is expressed in embryo and future hindbrain. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Cdk7 Products (1)

mRNA Protein Name
NM_009874.4 NP_034004.2 cyclin-dependent kinase 7

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase activity IDA
IDA: Inferred from direct assay
11319144 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17276355 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12748294 MGI
Cellular Component GO Annotation Evidence References Source
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
11319144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk7 Protein Structure

STKc_CDK7

STKc_CDK7: cd07841 (10 - 307)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 7

  • 39 kDa protein kinase

  • CDK-activating kinase

  • CR4 protein kinase

  • CRK4 PK (CDC2-related-kinase-4 protein kinase)

  • TFIIH basal transcription factor complex kinase subunit

  • cell division protein kinase 7

  • cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)

  • protein-tyrosine kinase MPK-7

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-13914 Roniciclib Inhibitor 98.00% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-161828A (S)-JWZ-5-13 Degrader 99.62% Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-138293 SY-5609 Inhibitor 99.93% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-123954 BTX-A51 Inhibitor 98.99% Phase 1
HY-128587 Mevociclib Inhibitor 99.73% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-139342 CDK7-IN-4 Inhibitor 98.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (96)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-101257 YKL-5-124 Inhibitor 99.53% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.52% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-N6954 Garcinone C Inhibitor 99.51% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-12653 LDC4297 Inhibitor 99.74% Unkown
HY-18285 Longdaysin Inhibitor 99.83% Unkown
HY-12293 LY2857785 Inhibitor 99.21% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.74% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-153278 Q901 Inhibitor 98.38% Unkown
HY-112403 (S)-Roscovitine Inhibitor 99.15% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-153278A Q901 TFA Inhibitor / Unkown
HY-12653A LDC4297 hydrochloride Inhibitor 98.23% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-116871 YKL-1-116 Inhibitor 98.67% Unkown
HY-14372 BS-194 Inhibitor 99.13% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-161830 CDK7 ligand 2 Degrader 99.92% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-123955 Casein Kinase inhibitor A86 Inhibitor 99.26% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-18969 LDC3140 Inhibitor 99.81% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-19988 THZ1-R Inhibitor 98.06% Unkown
HY-101257A CDK7-IN-1 Inhibitor 98.91% Unkown
HY-139011 IV-361 Inhibitor 99.60% Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-172194A (S)-JNJ-3738 Inhibitor / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-136711 CDK7-IN-2 hydrochloride hydrate Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-145655 CDK7-IN-11 Inhibitor / Unkown
HY-181565 CDK7-IN-33 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-147600 CDK7-IN-15 Inhibitor / Unkown
HY-162416 CDK7-IN-27 Inhibitor / Unkown
HY-145389 SZ-015268 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-183070 CXJ2080 Degrader / Unkown
HY-181528 JAK1/CDK7-IN-1 Inhibitor / Unkown
HY-180355 SY-5102 Inhibitor / Unkown
HY-147601 CDK7-IN-16 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-163721 CDK7-IN-29 Inhibitor / Unkown
HY-150948 CDK12 ligand-2 Ligand / Unkown
HY-145408 CDK7/9-IN-1 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-139986 CDK7-IN-5 Inhibitor / Unkown
HY-145394 CDK7-IN-6 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-170425 CDK7-IN-32 Inhibitor / Unkown
HY-145402 CDK7-IN-7 Inhibitor / Unkown
HY-169344 CDK7-IN-31 Inhibitor / Unkown
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-145424 CDK7-IN-10 Inhibitor / Unkown
HY-183071 CDK7 ligand 3 Degrader / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-143586 CDK7-IN-8 Inhibitor / Unkown
HY-183083 CDK7 ligand 3-CO-C5-COOH Ligand / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-123826 CCT68127 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk7 NCBI NCBI:1022