2. Gene
  3. Gcgr - glucagon receptor Gene

Gcgr - glucagon receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24953 | Gene type: protein coding

About Gcgr

Primary_assembly 10: 105,808,473-105,816,640 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 184 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in Liver (RPKM 26.9), Kidney (RPKM 67.8) and 5 other tissues.

Summary

Enables Glucagon Receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome and plasma membrane. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (Glucagon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gcgr Products(2)

mRNA Protein Name
NM_172092.2 NP_742089.1 glucagon receptor precursor
NM_172091.2 NP_742088.1 glucagon receptor precursor

Gcgr Protein Structure

HRM

HRM: pfam02793 (60 - 127)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (141 - 422)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (145 - 170)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (179 - 201)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (230 - 257)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (269 - 289)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (305 - 334)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (350 - 375)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (384 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

glucagon receptor

GL-R

glucagon receptor perhaps same as Niddm3

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114118 Semaglutide Agonist 99.84% Unkown
HY-13443 Exendin-4 Agonist 99.94% Yes
HY-P0014 Liraglutide Agonist 99.82% Unkown
HY-P0082 Glucagon (1-29), bovine, human 99.84% Unkown
HY-114118A Semaglutide TFA Agonist 99.92% Unkown
HY-P0119 Lixisenatide Agonist 99.93% Unkown
HY-P0119A Lixisenatide acetate Agonist 99.65% Unkown
Clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Phase
HY-P3463 Beinaglutide 99.74% Phase 4
HY-13443A Exendin-4 acetate Agonist 99.67% Phase 4
HY-P3506 Retatrutide Agonist 99.89% Phase 3
HY-112185 Orforglipron Agonist 99.57% Phase 3
HY-P3506A Retatrutide TFA Agonist 99.31% Phase 3
HY-P3375 Mazdutide Agonist 99.74% Phase 3
HY-P2221B Glepaglutide acetate Agonist 98.47% Phase 3
HY-P0165 Taspoglutide Agonist 99.51% Phase 3
HY-P3366 Ecnoglutide Agonist 98.61% Phase 3
HY-P2221 Glepaglutide Agonist / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-P3375A Mazdutide TFA Agonist / Phase 3
HY-P0264 Exendin(9-39) amide Antagonist 99.81% Phase 2
HY-50663 MK 0893 Antagonist 99.86% Phase 2
HY-19904 Adomeglivant Antagonist 98.18% Phase 2
HY-P2231A Cotadutide acetate Agonist 98.88% Phase 2
HY-P4146 Survodutide Agonist 99.98% Phase 2
HY-19947 PF-06291874 Antagonist 99.18% Phase 2
HY-12525 LGD-6972 Antagonist ≥98.0% Phase 2
HY-P4146A Survodutide TFA Agonist 99.62% Phase 2
HY-P10018 Bamadutide Agonist / Phase 2
HY-P3498 Elsiglutide Agonist / Phase 2
HY-P2231 Cotadutide Agonist / Phase 2
HY-P10031 SAR441255 Agonist / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99383 Volagidemab Antagonist 98.43% Phase 2
HY-P99357 Crotedumab Inhibitor 96.61% Phase 1
Pre-clinical Phase
Bioactive Molecules (95)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0055 GLP-1(7-37) 99.82% Unkown
HY-P0054 GLP-1(7-36), amide acetate 96.58% Unkown
HY-P0055A GLP-1(7-37) acetate 99.63% Unkown
HY-103546 BETP Agonist 99.28% Unkown
HY-10930 UNC0321 Inhibitor 99.80% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.84% Unkown
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% Unkown
HY-125824 Danuglipron Agonist 98.63% Unkown
HY-P1024 GLP-2(1-33)(human) Agonist 98.73% Unkown
HY-P1144 Oxyntomodulin (bovine, porcine) Agonist 99.91% Unkown
HY-153865 Lotiglipron Agonist 99.68% Unkown
HY-124622 NNC-0640 Modulator 98.10% Unkown
HY-121835 GLP-1R agonist 2 Agonist 99.94% Unkown
HY-P0054B GLP-1(7-36), amide TFA 98.04% Unkown
HY-103547 L-168049 Antagonist 99.93% Unkown
HY-P1348 GLP-1 moiety from Dulaglutide 95.02% Unkown
HY-P2625 GLP-2(3-33) Agonist 99.88% Unkown
HY-50159 Glucagon receptor antagonists-3 Antagonist 98.52% Unkown
HY-P3291 Dapiglutide Agonist 96.01% Unkown
HY-N0630 Shanzhiside methyl ester Agonist 99.32% Unkown
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% Unkown
HY-50158 Glucagon receptor antagonists-2 Antagonist 98.93% Unkown
HY-141839 GLP-1R modulator C16 Modulator 99.60% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-142162 LSN3318839 Modulator 99.81% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% Unkown
HY-P1145A Glucagon-like peptide 1 (1-37), human TFA Agonist 95.21% Unkown
HY-129658A TT-OAD2 Agonist 99.59% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.60% Unkown
HY-P0150 Glucagon (19-29), human Inhibitor 98.15% Unkown
HY-50675 GRA Ex-25 Inhibitor 98.59% Unkown
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 99.62% Unkown
HY-P3102 GLP-1(32-36)amide 98.42% Unkown
HY-P3101 GLP-1(28-36)amide 98.79% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-P1160 Bay 55-9837 Agonist 99.08% Unkown
HY-148844 GCGR antagonist 2 Antagonist 99.76% Unkown
HY-116819 VU0453379 Modulator ≥98.0% Unkown
HY-P2497 Exendin (5-39) Antagonist 99.81% Unkown
HY-P1231 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03% Unkown
HY-P1226 HAEGTFTSD Agonist 98.48% Unkown
HY-P1224 HAEGTFTSDVS 98.31% Unkown
HY-144034 GLP-1R agonist 3 Agonist 99.15% Unkown
HY-119739 Skyrin Antagonist / Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-10036 Glucagon receptor antagonists-1 Antagonist 98.65% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist / Unkown
HY-P0054A GLP-1(7-36), amide Agonist / Unkown
HY-145412 GLP-1 receptor agonist 7 98.41% Unkown
HY-P10032A NN1177 TFA Agonist / Unkown
HY-P1228 HAEGTFT 99.63% Unkown
HY-P5815A GLP-1 (1-36) amide (human, rat) (TFA) 98.81% Unkown
HY-P1229 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01% Unkown
HY-P1223 Exendin-3/4 (59-86) 98.19% Unkown
HY-P1225 {Val1}-Exendin-3/4 99.45% Unkown
HY-N2452 Cochinchinenin C Agonist / Unkown
HY-145458 GLP-1 receptor agonist 9 Agonist / Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-128781 Glucagon receptor antagonists-5 Antagonist / Unkown
HY-P1145 Glucagon-like peptide 1 (1-37), human Agonist / Unkown
HY-P5578 A8SGLP-1 Agonist / Unkown
HY-P10019 Pegsebrenatide Agonist / Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist / Unkown
HY-P0212A Neuropeptide Y, porcine TFA / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-P5074 GRPP (human) Agonist / Unkown
HY-P10341 ZP3022 Agonist / Unkown
HY-124803 GPCR modulator-1 Modulator / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-P3622 (Ser8)-GLP-1 (7-36) amide, human Agonist / Unkown
HY-P3616 Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide / Unkown
HY-129656 GLP-1 receptor agonist 3 Agonist / Unkown
HY-P10032 NN1177 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-P4672 (Met(O)27)-Glucagon (1-29) (human, rat, porcine) / Unkown
HY-P5815 GLP-1 (1-36) amide (human, rat) / Unkown
HY-P1144A Oxyntomodulin (bovine, porcine) (TFA) Agonist / Unkown
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-129658 TT-OAD2 free base Agonist / Unkown
HY-P3102A GLP-1(32-36)amide TFA / Unkown
HY-148212 GLP-1R agonist 17 Agonist / Unkown
HY-P1160A Bay 55-9837 TFA / Unkown
HY-P0082A Glucagon (1-29), bovine, human hydrochloride / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-P3621 Biotinyl-Glucagon (1-29), human, bovine, porcine / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-P3101A GLP-1(28-36)amide TFA / Unkown
HY-P3388 Utreglutide Agonist 98.42% Unkown
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / Unkown
HY-P5578A A8SGLP-1 TFA Agonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcgr NCBI NCBI:2642