KWZY-11
KWZY-11 (Compound 11) is a potent PARP/CDK6 dual inhibitor with IC50 values of 156.8, 197.3, and 13.3 nM for PARP1, PARP2, and CDK6, respectively. KWZY-11 inhibits tumor cell proliferation by regulating the Wnt/β-catenin signaling pathway. KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells.
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- CAS No.: 3077131-44-0
- 화학식: C28H27ClN8O2
- 분자량:543.02
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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CDK6 13.3 nM (IC50) |
PARP1 156.8 nM (IC50) |
PARP2 197.3 nM (IC50) |
Chemical Information
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CAS No. 3077131-44-0
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분자량 543.02
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화학식 C28H27ClN8O2
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SMILES
O=C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C5=NC6=C(N5)C=CC=C6C(N)=O)Cl)N(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KWZY-11 Related Classifications
HY-176713 Related Classifications
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