Protectin D1
Based on 1 Customer Validation
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders.
The product specifications provided below refer solely to the active content of Protectin D1.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.0%
- CAS No.: 660430-03-5
- 화학식: C22H32O4
- 분자량:360.49
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보관:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
The product specifications provided below refer solely to the active content of Protectin D1.
IC50 & Target
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Human Endogenous Metabolite |
IL-1β |
In Vitro
Protectin D1 (1 μM, 24h) exerts cardioprotective effects in primary neonatal rat cardiomyocytes by upregulating miRNA-210 expression and activating the PI3K/AKT signaling pathway[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary neonatal rat cardiomyocytes
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Concentration:1 μM
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Incubation Time:24h
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Result:Upregulated miRNA-210 expression.
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Cell Line:Primary neonatal rat cardiomyocytes
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Concentration:1 μM
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Incubation Time:24h
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Result:Increased p-AKT and HIF-1α protein levels.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:I/R-induced acute myocardial infarction (AMI) rat model, male Sprague Dawley rats (8 weeks old)[3]
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Dosage:0.5 μM/kg, 1 μM/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 3 days before surgery
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Result:Significantly reduced I/R-induced heart rate (HR), improved left ventricular ejection fraction (EF%) and fractional shortening (FS%), and reduced myocardial infarction area.
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Animal Model:Cecal ligation and puncture (CLP)-induced sepsis Wistar rat model (8 weeks old, 200 g)[4]
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Dosage:0.08 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose (12 hours before surgery)
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Result:Significantly reduced ROS concentration in hepatocytes of CLP-induced rats, decreased NALP3, ASC, and Caspase-1 expression levels, and lowered serum IL-18 and IL-1β concentrations.
Chemical Information
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CAS No. 660430-03-5
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Appearance Liquid
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분자량 360.49
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화학식 C22H32O4
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
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Synonyms
Neuroprotectin D1; NPD1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823. [Content Brief]
[2]. Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859. [Content Brief]
[3]. Zhang P, et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J Cardiovasc Transl Res. 2024 Apr;17(2):376-387. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protectin D1 Related Classifications
HY-130413 Related Classifications
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Keywords
- Protectin D1
- 660430-03-5
- Neuroprotectin D1
- NPD1
- Protectin D 1
- Protectin D-1
- Neuroprotectin D 1
- Neuroprotectin D-1
- NPD1
- NPD 1
- NPD-1
- Endogenous Metabolite
- PI3K
- Akt
- HIF/HIF Prolyl-Hydroxylase
- Reactive Oxygen Species (ROS)
- Caspase
- Interleukin Related
- MicroRNA
- Phosphoinositide 3-kinase
- PKB
- Protein kinase B
- Hypoxia-inducible factors
- HIFs
- HIF-PH
- IL
- miRNA
- neuroprotectin D1
- neural cell
- docosahexaenoic acid
- pro-resolving
- anti-inflammatory
- Inhibitor
- inhibitor
- inhibit