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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
respiratory viral infections
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "respiratory viral infections" in MCE Product Catalog:
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21 Publications Verification
Cat. No.: HY-U00434
CAS No.: 890405-51-3
Research Areas:
3BDO is a IFITM3 modulator and mTOR activator with antiviral and autophagy-inhibiting effects. 3BDO exhibits inhibitory activity against porcine coronaviruses. 3BDO increases the protein abundance of IFITM3, inhibits virus-cell membrane fusion, and blocks viral entry. 3BDO inhibits the entry of transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine respiratory coronavirus into host cells. 3BDO can be used for research on porcine coronavirus infection .
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1 Cited Publications
Cat. No.: HY-168034
CAS No.: 2138299-65-5
diABZI-4 is a STING activator and broad-spectrum antiviral agent with immunostimulatory activity. diABZI-4 triggers the TBK1-IRF3 and NF-κB signaling cascades by inducing STING oligomerization, thereby promoting the production of type I/III interferons and various proinflammatory cytokines. diABZI-4 exhibits broad-spectrum antiviral activity and effectively inhibits the replication of influenza A virus, SARS-CoV-2, herpes simplex virus, and other viruses. diABZI-4 also activates lymphocytes and macrophages to provide significant pre- and post-exposure protection in viral disease models. diABZI-4 can be used to study COVID-19, respiratory viral infections, and related immunopathological mechanisms .
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1 Cited Publications
Cat. No.: HY-N0677A
CAS No.: 76958-99-1
Synonyms: Potassium dehydroandrographolide succinate
Category:
Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Cancer
Target:
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Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice .
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1 Cited Publications
Cat. No.: HY-N0677
CAS No.: 786593-06-4
Cat. No.: HY-14837
CAS No.: 201349-37-3
Synonyms: Enisamium iodide
Target:
Research Areas:
Amizon is an orally effective antiviral and anti-inflammatory agent. Amizon inhibits influenza virus replication and restricts viral RNA synthesis. Amizon reduces the mRNA expression of COX-1, COX-2, NF-κB, TGF1β, IL-1 and IL-6, and stimulates the secretion and mRNA expression of IL-10. Amizon inhibits the oxidative activity of macrophages and possesses antioxidant and free radical-scavenging activities. Amizon is applicable to research related to influenza and acute respiratory viral infections .
Cat. No.: HY-N0891
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B
Cat. No.: HY-158405
CAS No.: 2923674-83-1
Synonyms: MAV-104
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PAV-104 (MAV-104) is a host-targeted, pan-respiratory viral assembly inhibitor. PAV-104 targets a small subset of the host protein 14-3-3 within a transient multi-protein complex. PAV-104 inhibits SARS-CoV-2 replication by blocking post-entry viral assembly/budding through interaction with viral nucleocapsid (N) protein and interference with its oligomerization. PAV-104 is orally active in cats and shows favorable pharmacokinetic properties in rats. PAV-104 can be used for the study of COVID-19 and other respiratory viral infections, including Feline Infectious Peritonitis (FIP) .
RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC50=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .
Cat. No.: HY-N14780
CAS No.: 544712-82-5
Synonyms: (+)-Pochonin D
Category:
Cat. No.: HY-138956
CAS No.: 1895861-88-7
MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection .
Cat. No.: HY-109072
CAS No.: 123606-06-4
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Riamilovir is an oral, broad-spectrum antiviral agent. Riamilovir can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2 .
Cat. No.: HY-N17236
CAS No.: 2767053-65-4
Target:
Cat. No.: HY-161877
CAS No.: 2694736-39-3
GS-7682 is an antiviral compound. GS-7682 has inhibitory activity against pneumoviruses and picornaviruses. GS-7682 can be used in the study of respiratory diseases such as asthma and chronic obstructive pulmonary disease .
Cat. No.: HY-N0891R
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B (Standard)
Category:
Cat. No.: HY-154968
CAS No.: 851658-28-1
RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .
Cat. No.: HY-109072A
CAS No.: 116061-59-7
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Riamilovir sodium is an oral, broad-spectrum antiviral agent. Riamilovir sodium can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir sodium can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2 .
Cat. No.: HY-185215
CAS No.: 1770840-57-7
Target:
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GS-646089 is a broad-spectrum antiviral nucleoside analog that exhibits significant inhibitory activity against respiratory syncytial virus (RSV), human metapneumovirus (hMPV), rhinovirus (enterovirus) and enteroviruses. The IC50 of GS-646089 targeting RNA-dependent RNA polymerase (RdRp) ranges from 43 to 46 nM. GS-646089 blocks viral replication by being converted into a triphosphate metabolite intracellularly, which competes with ATP for incorporation into nascent RNA strands and acts as an immediate chain terminator. GS-646089 is the parent compound of the double prodrug GS-7682 (HY-161877), and is used in studies of acute respiratory viral infections and infections caused by related pathogens .
Cat. No.: HY-120660
CAS No.: 1243324-08-4
AZD-4316 is a respiratory syncytial virus (RSV) L protein inhibitor. AZD-4316 has an inhibitory effect on RSV A subtypes (such as strain A2) and can effectively block viral replication in the early stage of infection (the viral entry stage). AZD-4316 is inactive when administered 12-24 hours after infection. AZD-4316 can be used for the research of RSV infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
