Cat. No.: HY-W009141

1-Monopalmitin

(Synonyms: Glyceryl palmitate)

Customer Review

Based on 1 Customer Validation

1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells.

For research use only. We do not sell to patients.

Purity: 99.89%
CAS No.: 542-44-9
Formula: C₁₉H₃₈O₄
Molecular Weight:330.51

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

1-Monopalmitin Chemical Structure

CAS No.: 542-44-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Akt Isoforms :

All PI3K Isoforms :

All IAP Isoforms :

All Caspase Isoforms :

In Vitro

1-Monopalmitin (0-100 μg/mL; 48 h) inhibits cell proliferation in lung cancer cells (A549, SPC-A1, H460, H1299) in a dose-dependent manner with low toxicity to normal bronchial epithelial cells HBE^[1].
1-Monopalmitin (50 μg/mL; 20 h) induces G2/M arrest in A549 and SPC-A1 cells, upregulates p21 protein and downregulates Cyclin D1^[1].
1-Monopalmitin (12.5-50 μg/mL; 48 h) promotes apoptosis of A549 and SPC-A1 cells, activates Caspase-3 and PARP cleavage, and inhibits the expression of inhibitor of apoptosis proteins (IAPs)^[1].
1-Monopalmitin (50 μg/mL; 8 h) induces protective autophagy in A549 and SPC-A1 cells, as evidenced by LC3-II accumulation and p62 degradation^[1].
1-Monopalmitin (0.1-300 μM; 2 h) increases Rhodamine-123 (HY-D0816) and Daunorubicin (HY-13062A) accumulation in a dose-dependent manner in intestinal Caco-2 cells, inhibits P-glycoprotein (P-gp) activity with non-cytotoxictiy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549, SPC-A1 (lung cancer cells); H460, H1299 (lung cancer cells); HBE (normal human bronchial epithelial cells)
Concentration:

0, 12.5, 25, 50, 75, 100, 150, 200 μg/mL
Incubation Time:

48 h
Result:

Significantly reduced viability of A549 (IC₅₀=50.12 μg/mL) and SPC-A1 (IC50=58.30 μg/mL) cells in a dose-dependent manner.
Showed higher IC₅₀ values against H460 and H1299 cells of 176.75 and 165.53 μg/mL, respectively; while exhibited IC50 of 161.34 μg/mL against normal HBE cells, indicating minimal toxicity to normal cells.

Chemical Information

CAS No. 542-44-9
Appearance Solid
Molecular Weight 330.51
Formula C₁₉H₃₈O₄
Color White to off-white
SMILES

OC(CO)COC(CCCCCCCCCCCCCCC)=O
Synonyms

Glyceryl palmitate
Initial Source
- Plants
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (151.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (151.28 mM; warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0256 mL

15.1281 mL

30.2563 mL

5 mM

0.6051 mL

3.0256 mL

6.0513 mL

10 mM

0.3026 mL

1.5128 mL

3.0256 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Niu L, et al. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro. Environmental Toxicology, 2023, 38(11): 2621-2631.

[2]. Tomoko Konishi, et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors. 2004;22(1-4):71-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	3.0256 mL	15.1281 mL	30.2563 mL	75.6407 mL
	5 mM	0.6051 mL	3.0256 mL	6.0513 mL	15.1281 mL
	10 mM	0.3026 mL	1.5128 mL	3.0256 mL	7.5641 mL
	15 mM	0.2017 mL	1.0085 mL	2.0171 mL	5.0427 mL
	20 mM	0.1513 mL	0.7564 mL	1.5128 mL	3.7820 mL
	25 mM	0.1210 mL	0.6051 mL	1.2103 mL	3.0256 mL
	30 mM	0.1009 mL	0.5043 mL	1.0085 mL	2.5214 mL
	40 mM	0.0756 mL	0.3782 mL	0.7564 mL	1.8910 mL
	50 mM	0.0605 mL	0.3026 mL	0.6051 mL	1.5128 mL
	60 mM	0.0504 mL	0.2521 mL	0.5043 mL	1.2607 mL
	80 mM	0.0378 mL	0.1891 mL	0.3782 mL	0.9455 mL
	100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7564 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

1-Monopalmitin

Apoptosis Compound Library

Membrane Transporter/Ion Channel Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Lipid Compound Library

Oxygen Sensing Compound Library

Medicine Food Homology Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Membrane Protein-targeted Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Chinese Baijiu Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

All Akt Isoforms

All PI3K Isoforms

All IAP Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

1-Monopalmitin Related Classifications

HY-W009141 Related Classifications