Multi-kinase-IN-7
Multi-kinase-IN-7 is a multikinase inhibitor with IC50s of 2.19, 2.95, 3.59 and 9.31 μM against EGFR, VEGFR2, TrKA and CDK2, respectively. Multi-kinase-IN-7 shows moderate and weaker activity against FAK, AKT1, GSK3β and CDK5 with IC50 values of 6.3, 9.2, 11.7 and 23.4 μM, respectively. Multi-kinase-IN-7 displays broad spectrum antiproliferative potential against NCI cancer cell lines. Multi-kinase-IN-7 induces cell cycle arrest, apoptosis and necrosis. Multi-kinase-IN-7 Inhibitor can be used for the study of breast cancer.
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- Formule: C18H13BrN6
- Masse moléculaire:393.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
EGFR 2.19 μM (IC50) |
VEGFR-2 2.95 μM (IC50) |
TrkA 3.59 μM (IC50) |
CDK2 9.31 μM (IC50) |
CDK5 23.4 μM (IC50) |
Akt1 9.2 μM (IC50) |
GSK3β 11.7 μM (IC50) |
Caspase 3 |
Bax |
Bcl-2 |
In Vitro
Multi-kinase-IN-7 (Compound 12b) (0.01-100 μM, 24 h) displays broad spectrum anti proliferative potential against NCI cancer cell lines with GI50 mean value of 10.63 μM and exhibits potent antiproliferative activities against all breast cancer lines with GI50 ranges of 4.03-15.3 μM[1].
Multi-kinase-IN-7 (15.3 μM, 48 h) arrests the cell cycle of MDA-MB-231 cells at the G2/M phase and significantly induces apoptosis (through intrinsic pathway) and necrosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:15.3 μM
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Incubation Time:48 h
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Result:Inhibited proliferation by blocking the G2/M phase.
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Cell Line:MDA-MB-231 cells
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Concentration:15.3 μM
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Incubation Time:48 h
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Result:Significantly induced apoptosis and necrosis, which are the main forms of cell death.
Increased activated Caspase-3 and Bax, and decreased Bcl-2.
Chemical Information
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Masse moléculaire 393.24
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Formule C18H13BrN6
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SMILES
N#CC1=C(N)N2C(NC1C3=CC=C(Br)C=C3)=NC(C4=CC=CC=C4)=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-kinase-IN-7 Related Classifications
HY-178142 Related Classifications
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