Cat. No.: HY-N1500

Pulegone

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Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.

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Pureté: 99.57%
CAS No.: 89-82-7
Formule: C₁₀H₁₆O
Masse moléculaire:152.23

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Pulegone Chemical Structure

CAS No.: 89-82-7

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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In Vitro

Pulegone (6.25-50 µg/mL; 20-26 h) can inhibit the expression of inflammatory mediators by downregulating the iNOS, COX-2, NF-κB, and MAPK signaling pathways and upregulating Nrf-2/HO-1 in LPS (HY-D1056)-stimulated RAW264.7 cells^[1].
Pulegone (0.01-3 mM; 0-5 min) can increase the intracellular Ca²⁺ concentration in chicken sensory neurons^[2].
Pulegone (0.01-3 mM; 0-5 min) can activate TRPM8 and TRPA1 and inhibit TRPM8 at high concentrations (1 mM and above) in HEK293 cells expressing chicken TRPM8, TRPA1, and TRPV1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS (HY-D1056)-stimulated RAW264.7 cells.
Concentration:

6.25, 12.5, 25 and 50 µg/mL
Incubation Time:

Pretreated with 2 h, then co-incubation for 18 h
Result:

Inhibited the expression of iNOS, COX-2 and NF-κB.
Downregulated phosphorylation of ERK, JNK, and p38.

In Vivo

Pulegone (100 mM; intraplantar injection; single dose) can induce pain-related behaviors in chicks, but these behaviors can be inhibited by a TRPA1 antagonist^[2].
Pulegone (10-150 mg/kg; intraperitoneal injection; single dose) has a beneficial effect in a rat model of inflammatory pain^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (300 g) treated Complete Freund's adjuvant (HY-153808)^[3].
Dosage:

10, 50, 100 and 150 mg/kg
Administration:

Intraperitoneal injection; single dose
Result:

Exerted an anti-hyperalgesic effect, increased the mechanical threshold, thermal heat threshold and decreased the thermal cold score at dose of 100 mg/kg.
Was devoid of in vivo locomotor side effects.

Chemical Information

CAS No. 89-82-7
Appearance Liquid (Density: 0.937 g/cm³)
Masse moléculaire 152.23
Formule C₁₀H₁₆O
Color Colorless to light yellow
SMILES

O=C1/C(CC[C@@H](C)C1)=C(C)/C
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
- Plants
- Labiatae
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Trop J Pharm Res

2022 Jun 4.

Solvant et solubilité

In Vitro:

DMSO : 233.33 mg/mL (1532.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.5690 mL

32.8450 mL

65.6901 mL

5 mM

1.3138 mL

6.5690 mL

13.1380 mL

10 mM

0.6569 mL

3.2845 mL

6.5690 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.25 mg/mL (14.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.25 mg/mL (14.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.25 mg/mL (14.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (419 KB)
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- Swedish - SV (419 KB)
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- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Roy A, et al. Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells. Natural Product Sciences, 2018, 24(1): 28-35.

[2]. Majikina A, et al. Involvement of nociceptive transient receptor potential channels in repellent action of pulegone. Biochem Pharmacol. 2018 May;151:89-95. [Content Brief]

[3]. Hilfiger L, et al. Anti-Hyperalgesic Properties of Menthol and Pulegone. Front Pharmacol. 2021 Nov 30;12:753873. [Content Brief]

[4]. Božović M, et al. Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry. Molecules. 2017 Feb 14;22(2). [Content Brief]

[5]. Flamini G, et al. Antimicrobial activity of the essential oil of Calamintha nepeta and its constituent pulegone against bacteria and fungi. Phytother Res. 1999 Jun;13(4):349-51. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.5690 mL	32.8450 mL	65.6901 mL	164.2252 mL
	5 mM	1.3138 mL	6.5690 mL	13.1380 mL	32.8450 mL
	10 mM	0.6569 mL	3.2845 mL	6.5690 mL	16.4225 mL
	15 mM	0.4379 mL	2.1897 mL	4.3793 mL	10.9483 mL
	20 mM	0.3285 mL	1.6423 mL	3.2845 mL	8.2113 mL
	25 mM	0.2628 mL	1.3138 mL	2.6276 mL	6.5690 mL
	30 mM	0.2190 mL	1.0948 mL	2.1897 mL	5.4742 mL
	40 mM	0.1642 mL	0.8211 mL	1.6423 mL	4.1056 mL
	50 mM	0.1314 mL	0.6569 mL	1.3138 mL	3.2845 mL
	60 mM	0.1095 mL	0.5474 mL	1.0948 mL	2.7371 mL
	80 mM	0.0821 mL	0.4106 mL	0.8211 mL	2.0528 mL
	100 mM	0.0657 mL	0.3285 mL	0.6569 mL	1.6423 mL

Pulegone

1 Cited Publications

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