VS1150
VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS). VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research.
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- CAS No.: 2855238-97-8
- Formule: C36H38Cl4N12O4
- Masse moléculaire:844.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
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Bcr-Abl 69 nM (EC50) |
STAT5 |
Caspase 8 |
Chemical Information
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CAS No. 2855238-97-8
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Masse moléculaire 844.58
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Formule C36H38Cl4N12O4
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SMILES
O=C(C1=CN=C(NCCOCCOCCNC2=NC=C(C(NC3=NN(C4=CC=C(Cl)C(Cl)=C4)CC3)=O)C(C)=N2)N=C1C)NC5=NN(C6=CC=C(Cl)C(Cl)=C6)CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VS1150 Related Classifications
HY-176269 Related Classifications
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