Cat. No.: HY-N7128

Flavanone

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Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy.

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Pureté: 99.73%
CAS No.: 487-26-3
Formule: C₁₅H₁₂O₂
Masse moléculaire:224.26

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Flavanone Chemical Structure

CAS No.: 487-26-3

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Aromatase

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

Voir tous les produits spécifiques à Isoform ERK :

Voir tous les produits spécifiques à Isoform p38 MAPK :

Voir tous les produits spécifiques à Isoform NF-κB :

Voir tous les produits spécifiques à Isoform MMP :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.2 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against A549 cells after 72 hrs by MTT assay Antiproliferative activity against A549 cells after 72 hrs by MTT assay	[PMID: 17137679]
Bel-7402	IC₅₀	>50 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against Bel7402 cells after 72 hrs by MTT assay	[PMID: 17137679]
BTI-TN-5B1-4	IC₅₀	2.87 μM Compound: 2a, racemic	Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay	[PMID: 20045650]
ECa-109 cell line	IC₅₀	27.7 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against ECA109 cells after 72 hrs by MTT assay Antiproliferative activity against ECA109 cells after 72 hrs by MTT assay	[PMID: 17137679]
H9	EC₅₀	58 μM Compound: 17	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	IC₅₀	45 μM Compound: 17	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
HL-60	IC₅₀	3.4 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against HL60 cells after 72 hrs by MTT assay Antiproliferative activity against HL60 cells after 72 hrs by MTT assay	[PMID: 17137679]
HL-60	IC₅₀	51.1 μM Compound: Flavanone	Cytotoxicity against human HL60 cells after 46 hrs by MTT assay Cytotoxicity against human HL60 cells after 46 hrs by MTT assay	[PMID: 23756061]
HL-60	IC₅₀	51.1 μM Compound: Flavanone	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 25091929]
HL-60	IC₅₀	51.1 μM Compound: Flavanone	Cytotoxicity against human HL60 cells assessed as reduction in cell survival after 46 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as reduction in cell survival after 46 hrs by MTT assay	[PMID: 27234147]
MCF7	IC₅₀	>25 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay	[PMID: 17137679]
NALM-6	IC₅₀	57.6 μM Compound: Flavanone	Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay	[PMID: 23756061]
NALM-6	IC₅₀	57.6 μM Compound: Flavanone	Cytotoxicity against human NALM6 cells by MTT assay Cytotoxicity against human NALM6 cells by MTT assay	[PMID: 25091929]
PC-3	IC₅₀	16.6 μg/mL Compound: 2-phenylchroman-4-one	Antiproliferative activity against PC3 cells after 72 hrs by MTT assay Antiproliferative activity against PC3 cells after 72 hrs by MTT assay	[PMID: 17137679]
WM-115	IC₅₀	71.2 μM Compound: Flavanone	Cytotoxicity against human WM115 cells after 46 hrs by MTT assay Cytotoxicity against human WM115 cells after 46 hrs by MTT assay	[PMID: 23756061]
WM-115	IC₅₀	71.2 μM Compound: Flavanone	Cytotoxicity against human WM115 cells by MTT assay Cytotoxicity against human WM115 cells by MTT assay	[PMID: 25091929]

In Vitro

Flavanone (0-100 μM, 48 h) inhibits the cell proliferation, migration and invasion of A549, arrests cell cycle at G1 phase^[2]^[3].
Flavanone (0-100 μM, 48 h) inhibits the expression of MMP-2, u-PA, cyclin D1 and CDK2, promotes the generation of TIMP-2 (MMP-2 inhibitor) and PAI-1 (u-PA inhibitor)^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[2]

Cell Line:

A549
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Inhibited cell migration.

Western Blot Analysis^[2]^[3]

Cell Line:

A549
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Reduced the expression of MMP-2, u-PA, cyclin D1 and CDK2, increased the expression of TIMP-2 and PAI-1.

In Vivo

Flavanone (100 mg/kg, po, once a day for 29 days) exhibits antitumor efficacy in C57BL/6J mouse models^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LLC xenograft C57BL/6J mouse models^[2]^[3]
Dosage:

100 mg/kg
Administration:

po, once a day for 29 days
Result:

Inhibited metastasis of LLC cells, limited tumor growth.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 487-26-3
Appearance Solid
Masse moléculaire 224.26
Formule C₁₅H₁₂O₂
Color Off-white to yellow
SMILES

O=C1CC(C2=CC=CC=C2)OC3=CC=CC=C13
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (445.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4591 mL

22.2956 mL

44.5911 mL

5 mM

0.8918 mL

4.4591 mL

8.9182 mL

10 mM

0.4459 mL

2.2296 mL

4.4591 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. JT Kellis Jr, et al. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep. 225 (4666):1032-1034.

[2]. Hsiao YC, et al., Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 May 1;167(3):193-206. [Content Brief]

[3]. Hsiao YC, et al., The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. J Biomed Sci. 2007 Jan;14(1):107-19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4591 mL	22.2956 mL	44.5911 mL	111.4778 mL
	5 mM	0.8918 mL	4.4591 mL	8.9182 mL	22.2956 mL
	10 mM	0.4459 mL	2.2296 mL	4.4591 mL	11.1478 mL
	15 mM	0.2973 mL	1.4864 mL	2.9727 mL	7.4319 mL
	20 mM	0.2230 mL	1.1148 mL	2.2296 mL	5.5739 mL
	25 mM	0.1784 mL	0.8918 mL	1.7836 mL	4.4591 mL
	30 mM	0.1486 mL	0.7432 mL	1.4864 mL	3.7159 mL
	40 mM	0.1115 mL	0.5574 mL	1.1148 mL	2.7869 mL
	50 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL
	60 mM	0.0743 mL	0.3716 mL	0.7432 mL	1.8580 mL
	80 mM	0.0557 mL	0.2787 mL	0.5574 mL	1.3935 mL
	100 mM	0.0446 mL	0.2230 mL	0.4459 mL	1.1148 mL

Keywords

Flavanone

1 Cited Publications

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Flavanone

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Publications Citing Use of MedChemExpress (MCE) Flavanone

Voir tous les produits spécifiques à Isoform Cytochrome P450

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Voir tous les produits spécifiques à Isoform p38 MAPK

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Voir tous les produits spécifiques à Isoform MMP

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité