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Resveratrol

(Synonyms: trans-Resveratrol; SRT501)
170 Cited Publications
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Based on 170 publication(s) in Google Scholar

Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

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  • Pureza: 99.95%
  • No. CAS: 501-36-0
  • Fòrmula: C14H12O3
  • Peso molecular:228.25
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Resveratrol Chemical Structure
    Resveratrol Chemical Structure
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
  • Experimental Validation Results for Resveratrol
No. CAS: 501-36-0
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  • Resveratrol Chemical Structure
    Resveratrol Chemical Structure
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    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Nov 19;5(11):101823. [Abstract]

    Customer Validation
     Resveratrol (10 μM). Proliferation rate measured at day 3 and day 7 in HSPCs treated with Vehicle or the indicated antioxidants (n=5).

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]

    Customer Validation
     Resveratrol (RES) (10 mg/kg/day; intraperitoneally injected every day for 5 weeks) administration recoveres DOX-reduced expression of SIRT1 in hearts of Sirt1flox/flox mice.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]

    Customer Validation
     Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. The protein expression of SIRT1, SESN2, P-AMPKα, AMPKα and cleaved caspase-3 was detected by western blot analysis with densitometric quantification of each group.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]

    Customer Validation
     Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. Representative images of DHE (red) staining and quantification of the corresponding fluorescence intensity in H9c2 cells.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]

    Customer Validation
     RES (10 mg/kg/day; i.p.; once daily for 5 weeks). The protein expression of SIRT1, SESN2, P-AMPKα, AMPKα, P-mammalian target of rapamycin (mTOR), P–S6 Ribosomal Protein (P–S6) and S6 was detected by western blot analysis with densitometric quantification in cardiac tissues of each group (n = 6).

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 Jun;150:113071. [Abstract]

    Customer Validation
     EX527 antagonizes the protective effect of NRH on Kanamycin-induced hair-cell loss by inhibition of SIRT1, while Resveratrol (RSV; 10 μM) alleviates hair-cell damage caused by EX527.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2022 Jun 30;20(6):e3001682. [Abstract]

    Customer Validation
     Immunostaining and brightfield of embryos either untreated or treated with solvent or with Resveratrol (1 μM).

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cells. 2022 Jul 29;11(15):2331. [Abstract]

    Customer Validation
     The depletion of HSF1 significantly decreased the reactivation efficiencies of Resveratrol.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Nov 29;12(12):1115. [Abstract]

    Customer Validation
     Western blot and quantification for MICU3 in C2C12 cells treated with d-gal and Resveratrol (50 μM).

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240. [Abstract]

    Customer Validation
     Representative images of Rhodamine and DHE of treated BMSCs after indicated treatment.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240. [Abstract]

    Customer Validation
     The expression levels of SIRT3, RUNX2, OCN in BMSCs after indicated treatment are analyzed by western blot.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2021 Mar;54(3):e12991. [Abstract]

    Customer Validation
     Representative immunoblots of Ac p53 K381, total p53, progerin, Lamin A/C and Lamin B1 of primary HSECs on Day 2 in four groups (CTR, H2O2, H2O2 + Resveratrol, Resveratrol (1 μM; 2 days)).

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2021 Apr 9;7(4):777-789. [Abstract]

    Customer Validation
     Effects of Resveratrol on meningitic E. coli-induced ERK1/2 activation as well as VEGFA upregulation in hBMECs. By pretreatment with Resveratrol, the phosphorylation of ERK1/2 induced by meningitic E. coli in hBMECs is significantly reduced. Similarly, the upregulation of VEGFA also decreased considerably in a dose-dependent manner in resveratrol-treated hBMECs.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251. [Abstract]

    Customer Validation
     Western blotting demonstrates that Resveratrol (50 mg/kg; i.p.; for 2 weeks) increases the expression of E-Ca and ZO-1 and decreases the expression of α-SMA, vimentin, snail, and twist.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251. [Abstract]

    Customer Validation
     Resveratrol (50 mg/kg; i.p.; for 2 weeks) has no effect on body weight and kidney index in mice, but it significantly reduces FBG, BUN, and CR.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]

    Customer Validation
     HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2017 Jun 7;65(22):4384-4394. [Abstract]

    Customer Validation
     Resveratrol activates the HSF1 signaling pathway. J-Lat A2 cells are treated with various concentrations of Resveratrol or Carfilzomib (50 nM) for 48 h. Then the cells are lysed and Ser320 phosphorylated HSF1 and total HSF1 are detected by Western blot with corresponding antibodies.

  • 1/16

    Resveratrol purchased from MedChemExpress. Usage Cited in: Chinese Journal of Cell Biology. 2015, 37(11):1522-1527.

    Customer Validation
     Effect of Resveratrol on SIRT1 expression in HK-2 cells.

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